DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Htr4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_032339.2	Gene:	Htr4 / 15562	MGIID:	109246	Length:	388	Species:	Mus musculus

Alignment Length:	357	Identity:	90/357 - (25%)
Similarity:	151/357 - (42%)	Gaps:	97/357 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLLSLLGNGTVVFVLLC---SRSKMDVPRFLVCNLAAADFFMGIYL---GILAIV-DAATLGE 819
            ||.|:::||| .:|.|.:|   ...|:....|:| :||.||..:.:.:   |.:.:| |....||
Mouse    28 VVILMAILGN-LLVMVAVCRDRQLRKIKTNYFIV-SLAFADLLVSVLVMPFGAIELVQDIWAYGE 90

  Fly   820 FRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAI--THAIHLNKRLSLKQAGYIMS 882
              ||         |.:...|.||.:..|::.|..|:|:|.|||  ...::.||...|:.|  :|.
Mouse    91 --MF---------CLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA--LML 142

  Fly   883 VG-WVFALIMALMPL------VGVSDY---RKFA------VCLPFETTTGPASLTYVISLMFING 931
            .| ||..:.::.:|:      :|:.|.   |||:      .|:  .....|.::|..:...:|
Mouse   143 GGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCV--FMVNKPYAITCSVVAFYI-- 203

  Fly   932 CAFLTLMGCYLKMYWAIRG--------SQAWNTNDSR-----------------IAKRMALLVFT 971
             .||.::..|.::|...:.        .:|..|::||                 .||.:.:::..
Mouse   204 -PFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGC 267

  Fly   972 DFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVL--PLNSCCNPFLYAIMTKQFKKD-CVTLCK 1033
            ...||:|   |.:|.|....:......:::|.|:.  .:||..||||||.:.|.|::. .:.||.
Mouse   268 FCFCWAP---FFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCC 329

  Fly  1034 HFEESRVVGGGGPGGRGAVARTKRGDLPPPLL 1065
            ..|                 |.||    ||:|
Mouse   330 DDE-----------------RYKR----PPIL 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	41/137 (30%)
		7tm_1	770..1017	CDD:278431	72/298 (24%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	81/317 (26%)
		TM helix 1	21..47	CDD:320184	9/19 (47%)
		TM helix 2	55..81	CDD:320184	7/26 (27%)
		TM helix 3	93..123	CDD:320184	11/29 (38%)
		TM helix 4	136..159	CDD:320184	7/24 (29%)
		TM helix 5	189..218	CDD:320184	7/31 (23%)
		TM helix 6	252..282	CDD:320184	8/32 (25%)
		TM helix 7	291..316	CDD:320184	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910