DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and CHADL

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens

Alignment Length:	607	Identity:	147/607 - (24%)
Similarity:	226/607 - (37%)	Gaps:	154/607 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 HCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIIN 217
            ||...| |...:.||:|          .:::|:|.:|:|.:|...:.....:|..|.|..|::..
Human   163 HCEVEL-VAEGAFRGLG----------RLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEE 216

  Fly   218 MDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRL 282
            :.|..|..|..|..|:|.:..|..||..:||||.::..|:|:.|||..|..:.|..|..||.|.|
Human   217 LRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSL 281

  Fly   283 EGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLT 347
            ..|....:|...|:..|.|..|.||.|.||...:||...:|.|..|||....:..:...|..:..
Human   282 HHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCP 346

  Fly   348 ALKVLELDDNLISSLPEGLSKLSQLQELSITSN----------RLRWI----------------- 385
            .|..|:|..|.:.:||. |....||:.|.:..|          .|.|:
Human   347 RLHTLDLRGNQLDTLPP-LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRL 410

  Fly   386 ---------------------NDTEL--------------------------------------- 390
                                 .:.||
Human   411 RGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESR 475

  Fly   391 ----------------PRSMQMLDMRAN------------------------PLSTISPGAFRGM 415
                            |...|:||:|.|                        .::.:..||..|:
Human   476 HSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGL 540

  Fly   416 SKLRKLILSDVRTL-RSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP 479
            .:|..|.|||.:.. .|...||....|..|.|:|....:||....|..|.|.||.|:.|::.|:.
Human   541 GRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLA 605

  Fly   480 --NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEG 542
              :|...|.||.:.||.|:|.::........::|..|.|..|:::.:|..|.:|:|.|..|.|.|
Human   606 PGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSG 670

  Fly   543 NEISYIHKEAFSGF-TALEDLNLGNNIFPELPESGLRAL------LHLKTFNNPKLREFPPPDTF 600
            |.:..:...||... .:|:.|.|.::...::.......|      |||:   ..:||..|...:.
Human   671 NPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQ---KNQLRALPALPSL 732

  Fly   601 PRIQTLIL-SYAYHC-CAFLPL 620
            .:::.:.| |..:|| |..|||
Human   733 SQLELIDLSSNPFHCDCQLLPL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	64/212 (30%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	20/59 (34%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	76/370 (21%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	20/181 (11%)
		leucine-rich repeat	372..393	CDD:275380	8/123 (7%)
		leucine-rich repeat	394..415	CDD:275380	7/44 (16%)
		leucine-rich repeat	418..486	CDD:275380	23/70 (33%)
		leucine-rich repeat	441..464	CDD:275378	7/22 (32%)
		LRR_8	487..545	CDD:290566	19/57 (33%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	15/62 (24%)
		leucine-rich repeat	535..558	CDD:275380	7/23 (30%)
		leucine-rich repeat	559..580	CDD:275380	3/20 (15%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380
		LRR_RI	<133..358	CDD:238064	64/205 (31%)
		LRR_8	133..214	CDD:290566	16/61 (26%)
		leucine-rich repeat	156..179	CDD:275380	7/26 (27%)
		leucine-rich repeat	180..203	CDD:275380	5/22 (23%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_8	228..286	CDD:290566	23/57 (40%)
		leucine-rich repeat	228..251	CDD:275380	10/22 (45%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		leucine-rich repeat	300..323	CDD:275380	9/22 (41%)
		LRR_8	322..380	CDD:290566	17/58 (29%)
		leucine-rich repeat	324..347	CDD:275380	5/22 (23%)
		LRR_4	346..>380	CDD:289563	11/34 (32%)
		LRRNT	463..497	CDD:214470	1/33 (3%)
		leucine-rich repeat	478..494	CDD:275380	1/15 (7%)
		LRR_RI	492..671	CDD:238064	50/178 (28%)
		leucine-rich repeat	495..518	CDD:275380	5/22 (23%)
		LRR_8	518..577	CDD:290566	15/58 (26%)
		leucine-rich repeat	519..542	CDD:275380	3/22 (14%)
		leucine-rich repeat	543..566	CDD:275380	8/22 (36%)
		LRR_8	565..625	CDD:290566	21/59 (36%)
		leucine-rich repeat	567..590	CDD:275380	7/22 (32%)
		leucine-rich repeat	591..614	CDD:275380	7/22 (32%)
		leucine-rich repeat	615..638	CDD:275380	6/22 (27%)
		LRR_8	637..698	CDD:290566	18/60 (30%)
		leucine-rich repeat	639..662	CDD:275380	7/22 (32%)
		leucine-rich repeat	663..687	CDD:275380	7/23 (30%)
		LRR_8	686..745	CDD:290566	12/61 (20%)
		leucine-rich repeat	688..712	CDD:275380	4/23 (17%)
		LRR_4	711..>744	CDD:289563	8/35 (23%)
		LRRCT	743..791	CDD:214507	6/12 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910