DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lgr5

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_034325.2	Gene:	Lgr5 / 14160	MGIID:	1341817	Length:	907	Species:	Mus musculus

Alignment Length:	914	Identity:	271/914 - (29%)
Similarity:	423/914 - (46%)	Gaps:	107/914 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 VIAGKRTLHSICERWLQKHCHC--TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLE 195
            |.||.........|....||||  .|.: :||:.|..:|:..:|.||......|||..||:::|.
Mouse    19 VAAGSSPGPDAIPRGCPSHCHCELDGRM-LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLP 82

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260
            |:.......||||.|:.|::.::...||.||..||.|.|||..|:.:|.::.|.|..|.||:|:.
Mouse    83 ASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDA 147

  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325
            |.:..:...|...|..||.|.|:.|....:|..|...|..|:|:.|..|.:..|.|..|..:.:|
Mouse   148 NHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSL 212

  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTEL 390
            :||.|..|:|..:.......|.:|:.|:|:.|.:...|..:..||.|:||...||.:|.|.:...
Mouse   213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAF 277

  Fly   391 PRSMQMLDMR--ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQE 453
            ..:..::.:.  .||:..:...||:.:.:||.|.|:....:..||.|.....||.|.|..|.|..
Mouse   278 VGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLTLTGAKISS 342

  Fly   454 VPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSY 518
            :|..:|.|.|.|:.|:|..|.|:.:|:||.|:.|:.:||..|:|.:|:|..|..|..|..|.|::
Mouse   343 LPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGSTFQQLFNLRSLNLAW 407

  Fly   519 NRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHL 583
            |:                        |:.||..|||...:|..|:|.:|:....|.:||..|.||
Mouse   408 NK------------------------IAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHL 448

  Fly   584 KTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAF---LPLVAMSSQKKTSQVQEAVLFPSDAEFD 645
            |...|..|:...|...||.::.:.:..||.||||   ..:..:|:|
Mouse   449 KLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQ------------------- 494

  Fly   646 MTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSG 710
               ||....|....:|  .|..|..              |:|.:..       :|::..:.:
Mouse   495 ---WNKDDGNSVDDLH--KKDAGLF--------------QVQDERD-------LEDFLLDFE--- 530

  Fly   711 PATGYGFGTGLFSGMSTEDFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTV 774
                             ||.:. .||||.|.||||.||..||..|.:|.|||...:|:|..|..|
Mouse   531 -----------------EDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALV 578

  Fly   775 VFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFL 839
            ...:..:...:...:.|:..:|..|..||:...:||.|||.|.|.|......|:..:.||:.|||
Mouse   579 ALTVFRTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFL 643

  Fly   840 AVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRK 904
            ::.:||.|::.|.:..|||.:::..:.....:..|.....|:.:..:.||.:|.:||:|.|.|..
Mouse   644 SIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAIVLLCVLLALTIATIPLLGGSKYNA 708

  Fly   905 FAVCLPF----ETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRM 965
            ..:|||.    .:|||     |:::|:.:|...||.:...|.|:|.::...:..|..|..:.|.:
Mouse   709 SPLCLPLPFGEPSTTG-----YMVALVLLNSLCFLIMTIAYTKLYCSLEKGELENLWDCSMVKHI 768

  Fly   966 ALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVT 1030
            |||:|.:.:.:.|:||.|.:::..|..||.:..|...:.::||.||.||.||.:....||:|..:
Mouse   769 ALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGS 833

  Fly  1031 LCKH 1034
            |.||
Mouse   834 LGKH 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	68/202 (34%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	25/59 (42%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	72/241 (30%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	16/56 (29%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..486	CDD:275380	26/67 (39%)
		leucine-rich repeat	441..464	CDD:275378	9/22 (41%)
		LRR_8	487..545	CDD:290566	13/57 (23%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		LRR_8	533..589	CDD:290566	17/55 (31%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433	34/127 (27%)
		7tm_1	770..1017	CDD:278431	73/250 (29%)
Lgr5	NP_034325.2	LRRNT	33..70	CDD:214470	12/37 (32%)
		leucine-rich repeat	68..91	CDD:275380	7/22 (32%)
		LRR_RI	88..386	CDD:238064	97/297 (33%)
		LRR_8	92..150	CDD:290566	25/57 (44%)
		leucine-rich repeat	92..115	CDD:275380	10/22 (45%)
		leucine-rich repeat	116..139	CDD:275380	10/22 (45%)
		LRR_8	138..198	CDD:290566	19/59 (32%)
		leucine-rich repeat	140..163	CDD:275380	7/22 (32%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		LRR_8	188..246	CDD:290566	18/57 (32%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..258	CDD:275380	6/21 (29%)
		LRR_8	257..314	CDD:290566	16/56 (29%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		LRR_8	352..410	CDD:290566	23/81 (28%)
		leucine-rich repeat	354..375	CDD:275378	9/20 (45%)
		leucine-rich repeat	376..389	CDD:275378	5/12 (42%)
		leucine-rich repeat	400..423	CDD:275378	10/46 (22%)
		leucine-rich repeat	445..467	CDD:275378	8/21 (38%)
		7tm_1	575..820	CDD:278431	73/249 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7798
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20807
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2026
Isobase	1	0.950	-	0	Normalized mean entropy	S5677
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43490
orthoMCL	1	0.900	-	-		OOG6_106088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2481
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.680