DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Lgr5

DIOPT Version :10

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_034325.2 Gene:Lgr5 / 14160 MGIID:1341817 Length:907 Species:Mus musculus


Alignment Length:914 Identity:271/914 - (29%)
Similarity:423/914 - (46%) Gaps:107/914 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 VIAGKRTLHSICERWLQKHCHC--TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLE 195
            |.||.........|....||||  .|.: :||:.|..:|:..:|.||......|||..||:::|.
Mouse    19 VAAGSSPGPDAIPRGCPSHCHCELDGRM-LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLP 82

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260
            |:.......||||.|:.|::.::...||.||..||.|.|||..|:.:|.::.|.|..|.||:|:.
Mouse    83 ASLLHRLCFLEELRLAGNALTHIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDA 147

  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325
            |.:..:...|...|..||.|.|:.|....:|..|...|..|:|:.|..|.:..|.|..|..:.:|
Mouse   148 NHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSL 212

  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTEL 390
            :||.|..|:|..:.......|.:|:.|:|:.|.:...|..:..||.|:||...||.:|.|.:...
Mouse   213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAF 277

  Fly   391 PRSMQMLDMR--ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQE 453
            ..:..::.:.  .||:..:...||:.:.:||.|.|:....:..||.|.....||.|.|..|.|..
Mouse   278 VGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLTLTGAKISS 342

  Fly   454 VPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSY 518
            :|..:|.|.|.|:.|:|..|.|:.:|:||.|:.|:.:||..|:|.:|:|..|..|..|..|.|::
Mouse   343 LPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGSTFQQLFNLRSLNLAW 407

  Fly   519 NRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHL 583
            |:                        |:.||..|||...:|..|:|.:|:....|.:||..|.||
Mouse   408 NK------------------------IAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHL 448

  Fly   584 KTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAF---LPLVAMSSQKKTSQVQEAVLFPSDAEFD 645
            |...|..|:...|...||.::.:.:..||.||||   ..:..:|:|                   
Mouse   449 KLTGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQ------------------- 494

  Fly   646 MTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSG 710
               ||....|....:|  .|..|..              |:|.:..       :|::..:.:   
Mouse   495 ---WNKDDGNSVDDLH--KKDAGLF--------------QVQDERD-------LEDFLLDFE--- 530

  Fly   711 PATGYGFGTGLFSGMSTEDFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTV 774
                             ||.:. .||||.|.||||.||..||..|.:|.|||...:|:|..|..|
Mouse   531 -----------------EDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALV 578

  Fly   775 VFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFL 839
            ...:..:...:...:.|:..:|..|..||:...:||.|||.|.|.|......|:..:.||:.|||
Mouse   579 ALTVFRTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRFAQHGAWWEDGIGCQIVGFL 643

  Fly   840 AVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRK 904
            ::.:||.|::.|.:..|||.:::..:.....:..|.....|:.:..:.||.:|.:||:|.|.|..
Mouse   644 SIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLRAIVLLCVLLALTIATIPLLGGSKYNA 708

  Fly   905 FAVCLPF----ETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRM 965
            ..:|||.    .:|||     |:::|:.:|...||.:...|.|:|.::...:..|..|..:.|.:
Mouse   709 SPLCLPLPFGEPSTTG-----YMVALVLLNSLCFLIMTIAYTKLYCSLEKGELENLWDCSMVKHI 768

  Fly   966 ALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVT 1030
            |||:|.:.:.:.|:||.|.:::..|..||.:..|...:.::||.||.||.||.:....||:|..:
Mouse   769 ALLLFANCILYCPVAFLSFSSLLNLTFISPDVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGS 833

  Fly  1031 LCKH 1034
            |.||
Mouse   834 LGKH 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 LRR <157..390 CDD:443914 77/232 (33%)
leucine-rich repeat 158..179 CDD:275380 7/20 (35%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR 292..612 CDD:443914 95/321 (30%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 4/22 (18%)
leucine-rich repeat 418..486 CDD:275380 26/67 (39%)
leucine-rich repeat 441..464 CDD:275378 9/22 (41%)
leucine-rich repeat 487..510 CDD:275380 9/22 (41%)
leucine-rich repeat 511..534 CDD:275380 4/22 (18%)
leucine-rich repeat 535..558 CDD:275380 6/22 (27%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 84/277 (30%)
TM helix 1 755..781 CDD:320264 8/25 (32%)
TM helix 2 788..813 CDD:320264 7/24 (29%)
TM helix 3 833..863 CDD:320264 12/29 (41%)
TM helix 4 875..897 CDD:320264 5/21 (24%)
TM helix 5 918..947 CDD:320264 8/28 (29%)
TM helix 6 956..986 CDD:320264 10/29 (34%)
TM helix 7 996..1021 CDD:320264 9/24 (38%)
Lgr5NP_034325.2 LRRNT 33..65 CDD:396168 11/32 (34%)
leucine-rich repeat 68..91 CDD:275380 7/22 (32%)
LRR 92..468 CDD:443914 128/399 (32%)
leucine-rich repeat 92..115 CDD:275380 10/22 (45%)
leucine-rich repeat 116..139 CDD:275380 10/22 (45%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
leucine-rich repeat 188..211 CDD:275380 7/22 (32%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..258 CDD:275380 6/21 (29%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
leucine-rich repeat 283..304 CDD:275380 4/20 (20%)
leucine-rich repeat 354..375 CDD:275378 9/20 (45%)
leucine-rich repeat 376..389 CDD:275378 5/12 (42%)
leucine-rich repeat 400..423 CDD:275378 10/46 (22%)
leucine-rich repeat 445..467 CDD:275378 8/21 (38%)
7tmA_LGR5 558..831 CDD:320485 84/277 (30%)
TM helix 1 559..585 CDD:320485 8/25 (32%)
TM helix 2 592..617 CDD:320485 7/24 (29%)
TM helix 3 637..667 CDD:320485 12/29 (41%)
TM helix 4 679..701 CDD:320485 5/21 (24%)
TM helix 5 721..750 CDD:320485 11/33 (33%)
TM helix 6 759..789 CDD:320485 10/29 (34%)
TM helix 7 799..824 CDD:320485 9/24 (38%)

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