DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and ADORA2B

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_000667.1	Gene:	ADORA2B / 136	HGNCID:	264	Length:	332	Species:	Homo sapiens

Alignment Length:	339	Identity:	78/339 - (23%)
Similarity:	138/339 - (40%)	Gaps:	83/339 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLLSLLGNGTVVFVLLC----SRSKMDVP-RFLVCNLAAADFFMGIYLGILAIVDAATLGEFR 821
            |:..||:.||     ||:|    :.:.:..| .:.:.:|||||..:|
Human    16 VIAALSVAGN-----VLVCAAVGTANTLQTPTNYFLVSLAAADVAVG------------------ 57

  Fly   822 MFAIPWQMSV---LCQ-------LSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQ 876
            :||||:.:::   .|.       |:.|:.|| ::.|:::|..:.::|..||...:.....::..:
Human    58 LFAIPFAITISLGFCTDFYGCLFLACFVLVL-TQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTR 121

  Fly   877 AGYIMSVGWVFALIMALMPLVG--VSDYRKFAVCLPFETTTGPA------------SLTYVISLM 927
            |..:::|.||.|..:.|.|.:|  ..|........|::.||..:            .::|::...
Human   122 ARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFN 186

  Fly   928 FINGCA---FLTLMGCYLKMYW-AIRGSQAWNTND-SR--------IAKRMALLVFTDFLCWSPI 979
            |. ||.   .|.::..|:|::. |.|..|.....| ||        .||.:|::|....|||.|:
Human   187 FF-GCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPV 250

  Fly   980 AFFSITAIF----GLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKK------DCVTLCKH 1034
            ...:...:|    |..  ..:.|....:.:...||..||.:||...:.|:.      ....||
Human   251 HAVNCVTLFQPAQGKN--KPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLC-- 311

  Fly  1035 FEESRVVGGGGPGG 1048
              ::.|..|.|..|
Human   312 --QADVKSGNGQAG 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	33/142 (23%)
		7tm_1	770..1017	CDD:278431	66/292 (23%)
ADORA2B	NP_000667.1	7tmA_Adenosine_R_A2B	8..301	CDD:320197	72/311 (23%)
		TM helix 1	9..35	CDD:320197	8/23 (35%)
		TM helix 2	42..69	CDD:320197	10/44 (23%)
		TM helix 3	78..108	CDD:320197	8/30 (27%)
		TM helix 4	122..140	CDD:320197	6/17 (35%)
		Agonist binding. /evidence=ECO:0000250	173..182		0/8 (0%)
		TM helix 5	179..209	CDD:320197	7/30 (23%)
		TM helix 6	227..257	CDD:320197	8/29 (28%)
		Agonist binding. /evidence=ECO:0000250	247..254		2/6 (33%)
		Agonist binding. /evidence=ECO:0000250	266..276		1/11 (9%)
		TM helix 7	269..294	CDD:320197	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910