DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and LRRC15

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	465	Identity:	141/465 - (30%)
Similarity:	198/465 - (42%)	Gaps:	72/465 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 CERW---LQKH-----CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFF 200
            |:.|   |..|     |.|:.:.:|   .|.|..|:|||..||...:.|.:.|.::|:|..:.|.
Human    19 CQAWGAGLAYHGCPSECTCSRASQV---ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFL 80

  Fly   201 MAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVS 265
            ....|..|.:..|.:..:.|.||..|..|:.|||.|..|:.||...||||..|.||.|:.|.|:.
Human    81 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145

  Fly   266 LDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLL 330
            :..........|:.|:|.||....||..|...|..|..||||.|.||.|:...|..:.||.||.|
Human   146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 210

  Fly   331 KRNQIMKISAGALKNLTALKVLELDDNLISSLPEGL-SKLSQLQELSITSNRLRWINDTELPRSM 394
            ..|::..|..|....|..|:.|.|..|.|..|..|| .....||.|.:::|.:     ::||.|:
Human   211 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHI-----SQLPPSV 270

  Fly   395 QM-------LDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQ 452
            .|       |.:..|.|..:|||.|..|..||:|.|.|..                       |.
Human   271 FMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNH-----------------------IS 312

  Fly   453 EVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLS 517
            .:|.|:                      .|:.|.|::|.||.|||..|....||||.:|.:|.|.
Human   313 SLPDNV----------------------FSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLH 355

  Fly   518 YNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP---ESGLRA 579
            .|.::.|..:.|:.:..||.:.|:.|.:..:....|:....|..:.|.||....||   ...|..
Human   356 TNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGK 420

  Fly   580 LLHLKTFNNP 589
            |..|:.::||
Human   421 LCELRLYDNP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	70/203 (34%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	12/22 (55%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	23/59 (39%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	66/247 (27%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	20/61 (33%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	8/27 (30%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	22/57 (39%)
		leucine-rich repeat	487..510	CDD:275380	12/22 (55%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	14/58 (24%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	7/23 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	17/58 (29%)
		LRR_RI	63..309	CDD:238064	86/250 (34%)
		LRR_8	88..167	CDD:290566	29/78 (37%)
		leucine-rich repeat	88..108	CDD:275380	6/19 (32%)
		leucine-rich repeat	109..156	CDD:275380	18/46 (39%)
		leucine-rich repeat	157..180	CDD:275380	9/22 (41%)
		LRR_8	180..239	CDD:290566	23/58 (40%)
		leucine-rich repeat	181..204	CDD:275380	10/22 (45%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		LRR_8	228..287	CDD:290566	18/63 (29%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		leucine-rich repeat	253..276	CDD:275380	8/27 (30%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	26/104 (25%)
		LRR_4	299..340	CDD:289563	18/85 (21%)
		leucine-rich repeat	301..324	CDD:275380	9/67 (13%)
		LRR_4	324..364	CDD:289563	17/39 (44%)
		leucine-rich repeat	325..348	CDD:275380	12/22 (55%)
		leucine-rich repeat	349..370	CDD:275380	6/20 (30%)
		LRR_8	372..430	CDD:290566	14/57 (25%)
		leucine-rich repeat	373..393	CDD:275380	5/19 (26%)
		leucine-rich repeat	397..418	CDD:275380	6/20 (30%)
		TPKR_C2	429..>468	CDD:301599	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910