DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and GPRGPH

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_321252.4	Gene:	GPRGPH / 1281307	VectorBaseID:	AGAP001807	Length:	746	Species:	Anopheles gambiae

Alignment Length:	815	Identity:	199/815 - (24%)
Similarity:	299/815 - (36%)	Gaps:	264/815 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 GLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLE 302
            ||..||  |......:|.|.|.||..:.|:.:......||.||.|......||....|||  :::
Mosquito   145 GLTGLP--SVLTSENVTLLDLTGNVFIELNMNVFQRFPKLSTLVLRHCSIERIEPVKLAG--SID 205

  Fly   303 ALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEG-L 366
            ||:|..|.||.:.|:.||....|.:|:|..|:|.::......||..|:.|:|.||.|.:|.|. |
Mosquito   206 ALHLDQNGLTTLPDDFFPPGTVLRILVLSGNRINRLGRTNFVNLEFLEELDLKDNQIDALTEDVL 270

  Fly   367 SKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRS 431
            :.|:.|:.|.:.:||||                      .:.||.
Mosquito   271 APLTNLRILYLNNNRLR----------------------KLVPGM-------------------- 293

  Fly   432 FPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQ 496
                                  :||.:..||                           |.|:.||
Mosquito   294 ----------------------IPALVTLQT---------------------------LSLARNQ 309

  Fly   497 IEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALED 561
            ||.|:....: |..|..|.||.|.:..:..|.|..:..|...:|:||:...|.:......|.|..
Mosquito   310 IETIEVCALD-LPSLEHLYLSENLLTVIRNDTFGNLTNLVGFNLQGNKFDRIDRRVLDNLTNLHH 373

  Fly   562 LNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQ 626
            ::     |.|...  .:|.||::...       |..|                       .:||.
Mosquito   374 IH-----FTEFHH--CKAALHVRVCE-------PKGD-----------------------GISSN 401

  Fly   627 KKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTG 691
            :.                   |.:|.:             |.|....|:|:::.          .
Mosquito   402 RH-------------------LLDNPV-------------LRARYERPYESSVR----------S 424

  Fly   692 GQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTL 756
            ..|||                                   |.||..|.:
Mosquito   425 RHIAT-----------------------------------PMSVFQLAL---------------- 438

  Fly   757 RCGVWVVFLLSLLGNGTVVF--VLLCSRSKMDVPR--FLVCNLAAADFFMGIYLGILAIVDAATL 817
             ..||::..:.::||..|:|  .::.|||......  ..:.:|||:|..||:||||:|..|....
Mosquito   439 -SFVWIMAAIGIVGNLLVLFGRYVVGSRSSQAHAEHSLYLRHLAASDLLMGVYLGIIATADIIFR 502

  Fly   818 GEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYI-M 881
            ||:......|:||.:|..||||:.||.:.|...|.::|.:|..::|..::  :|.|.|....: :
Mosquito   503 GEYLTHDEEWRMSSICAFSGFLSTLSCQSSTLLLTLVTWDRLVSVTRPLY--QRSSSKTRVILRL 565

  Fly   882 SVGWVFALIMALMPL-----VGVSDYRKFAVCL------PF----ETTTGPASLTYVISLMFING 931
            :|.|..|...|:.||     .|...|....|||      |:    |.:.|...|...:||:|| |
Mosquito   566 AVLWGVATAAAIAPLSATEYFGPHFYGSNGVCLSVHIHDPYAMGWEYSAGLFILVNTVSLLFI-G 629

  Fly   932 CAFLTLMGCYLKMYWAIRGSQ-----AWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQ 991
            .:       ||:|..|||.|:     ..|..:..:|:|.|::|.||.:||.|:....:.|:.|.:
Mosquito   630 IS-------YLRMLQAIRVSRNETRNTLNCREKVVARRFAIIVATDCVCWMPVIVVKLVALAGYE 687

  Fly   992 LISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKK 1026
             ||........|.|||:||..||.||.:.|.|||:
Mosquito   688 -ISPSLYAWLAVLVLPINSALNPVLYTLTTAQFKQ 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	51/145 (35%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	10/24 (42%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	5/13 (38%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	50/240 (21%)
		leucine-rich repeat	349..371	CDD:275380	10/22 (45%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	4/67 (6%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	19/57 (33%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	12/55 (22%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	3/20 (15%)
		7tm_4	764..>892	CDD:304433	42/132 (32%)
		7tm_1	770..1017	CDD:278431	88/271 (32%)
GPRGPH	XP_321252.4	LDLa	59..94	CDD:238060
		leucine-rich repeat	137..157	CDD:275380	5/13 (38%)
		LRR_RI	<144..334	CDD:238064	72/284 (25%)
		LRR_8	157..214	CDD:290566	20/58 (34%)
		leucine-rich repeat	158..181	CDD:275380	6/22 (27%)
		leucine-rich repeat	182..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..227	CDD:275380	9/22 (41%)
		LRR_8	228..286	CDD:290566	20/57 (35%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	274..333	CDD:290566	25/150 (17%)
		leucine-rich repeat	276..299	CDD:275380	10/86 (12%)
		leucine-rich repeat	300..322	CDD:275380	10/49 (20%)
		LRR_8	321..375	CDD:290566	14/53 (26%)
		LRR_4	321..361	CDD:289563	11/39 (28%)
		leucine-rich repeat	323..346	CDD:275380	7/22 (32%)
		leucine-rich repeat	347..370	CDD:275380	5/22 (23%)
		7tm_4	444..723	CDD:304433	94/289 (33%)
		7tm_1	451..712	CDD:278431	88/271 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910