DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP012425

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_320129.3	Gene:	AgaP_AGAP012425 / 1280456	VectorBaseID:	AGAP012425	Length:	472	Species:	Anopheles gambiae

Alignment Length:	328	Identity:	94/328 - (28%)
Similarity:	143/328 - (43%)	Gaps:	72/328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 QGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLT 312
            :|:...||.|: |..|..|:     ..|.|.|..|:..|.:.:.|    ||:.:
Mosquito    26 KGVFDCTSKQI-GATLFPLE-----DWQSLNTNGLDAKLVFLVST----GLKEI----------- 69

  Fly   313 IINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLS---------- 367
                ..||.| |:..|.|..|:|..:..|...|||.|:||:|..|.:.|  |.|:
Mosquito    70 ----THFPSM-NVTWLDLSHNEIATMKTGCFANLTLLQVLDLSHNRLKS--ESLNPDVFAGHYST 127

  Fly   368 ----KLSQLQELSITSNRLRWIND---TELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSD 425
                .||:|:.|.:.:|.|..:|.   ..|| :::.|.:..||...|...:...::.:.:|:..|
Mosquito   128 NEYMPLSKLRVLRLGANDLHSLNPDLFEHLP-ALEELSLELNPFKVIDQQSEIAIASIERLVSLD 191

  Fly   426 VRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPR-LKSLELKTNSLKRIP-NLSSCRDLR 488
            :    |:.|||                ::|..|. .||| |:.|.|..|.|:.:| .||....|.
Mosquito   192 L----SYMELE----------------DIPKYLF-HTPRGLRYLNLTGNLLQEVPAALSYATALA 235

  Fly   489 LLDLSSNQIEKI-QGKPFNGLKQLNDLLLSY-NRIKALPQDAFQGIPKLQLLDLEGN-EISYIHK 550
            .|.|..|.|..| .|..|..||||..|.||| :::|.:.:.||.|:..||.:.:..| .::|:|.
Mosquito   236 WLSLDENPISSIVVGTEFPSLKQLTFLSLSYMSQLKVIGRGAFSGLESLQEVHITNNPHLTYLHG 300

  Fly   551 EAF 553
            .||
Mosquito   301 HAF 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	40/148 (27%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	5/14 (36%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	1/3 (33%)
		LRR_8	252..311	CDD:290566	14/58 (24%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	3/22 (14%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	75/249 (30%)
		leucine-rich repeat	349..371	CDD:275380	9/35 (26%)
		LRR_8	370..425	CDD:290566	13/57 (23%)
		leucine-rich repeat	372..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	19/69 (28%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	23/60 (38%)
		leucine-rich repeat	487..510	CDD:275380	9/23 (39%)
		leucine-rich repeat	511..534	CDD:275380	9/23 (39%)
		LRR_8	533..589	CDD:290566	7/22 (32%)
		leucine-rich repeat	535..558	CDD:275380	7/20 (35%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP012425	XP_320129.3	LRR_RI	<55..267	CDD:238064	71/255 (28%)
		LRR_8	76..146	CDD:290566	22/71 (31%)
		leucine-rich repeat	77..100	CDD:275380	7/22 (32%)
		leucine-rich repeat	101..135	CDD:275380	9/35 (26%)
		LRR_8	134..194	CDD:290566	14/64 (22%)
		leucine-rich repeat	136..159	CDD:275380	7/23 (30%)
		leucine-rich repeat	160..186	CDD:275380	4/25 (16%)
		LRR_8	186..244	CDD:290566	23/78 (29%)
		leucine-rich repeat	187..210	CDD:275380	10/43 (23%)
		leucine-rich repeat	211..233	CDD:275380	8/21 (38%)
		leucine-rich repeat	234..258	CDD:275380	9/23 (39%)
		LRR_8	257..329	CDD:290566	18/47 (38%)
		leucine-rich repeat	259..283	CDD:275380	9/23 (39%)
		leucine-rich repeat	284..305	CDD:275380	7/20 (35%)
		leucine-rich repeat	343..355	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910