DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP012317

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_320227.3	Gene:	AgaP_AGAP012317 / 1280380	VectorBaseID:	AGAP012317	Length:	458	Species:	Anopheles gambiae

Alignment Length:	425	Identity:	108/425 - (25%)
Similarity:	163/425 - (38%)	Gaps:	122/425 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DMQNSQEQEPYVHL---------QHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVML 99
            |:.||....|.|.:         :..|:..:|.||     ..:.::.:..:.:|.|..:.|
Mosquito    36 DVHNSPTGLPEVQIDCRKHQLGDEFWQESSEQMPQ-----GTVRLDLSRNALTVVPRLVGE---- 91

  Fly   100 PSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLS 164
                     |:.|   |...|    :..:|..|.:.|..:|                 ||.|.||
Mosquito    92 ---------QLRY---LNLGH----NQITTIPDKVFGNVSL-----------------LEELDLS 123

  Fly   165 CRGIGILAVP--VNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLA 227
            ...|.:|...  ..||| :.::||.:|.:||:|.|:|..|.:|.:|.||:||:     .||:...
Mosquito   124 SNRIEMLGTDALAGLPN-LKLIDLSSNLITKIEVNAFSNALHLSQLKLSNNSL-----GAFFNRT 182

  Fly   228 ------------KLKRLSLQNCGLKSLPPQSFQGL-----------------AQLTSLQLNGNAL 263
                        :|..|.::.|.|..:...|..||                 .||..|.::|..:
Mosquito   183 EADLYLRLGVTNRLAVLEMERCNLTDINLSSGVGLERALLGYNRLQQLSKLPKQLAYLDISGTPI 247

  Fly   264 VSLDGDCLGHLQKLRTLRLEG-NLFYRIPTNALAGLRTLEALNL-GSNLLTIINDEDFPRMPNLI 326
            .||....|.||..|.:|.|:. .:.|.:...||.||..|..||| ||..|:.|:...|.:  |:|
Mosquito   248 RSLPAKFLPHLLHLESLILQDMPILYTLEEYALYGLPRLSMLNLQGSRNLSTIHPHVFGQ--NVI 310

  Fly   327 VLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLS-KLSQLQELSITSN------RLRW 384
                 ||:          ..|.||.|.|....|.:|...|. ....|:.|.|...      :|||
Mosquito   311 -----RNE----------TDTELKRLILKGTNIRTLNSTLQFAFENLRLLDIRGAPLRCDCQLRW 360

  Fly   385 INDTELPRSMQM-LDMRANPL-----STISPGAFR 413
            :.  |||..|.: :.::.|.|     .||.|..|:
Mosquito   361 LR--ELPNLMTLGVCVKPNALRDKRFGTIDPHQFQ 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/22 (36%)
		LRR_RI	180..>383	CDD:238064	65/240 (27%)
		leucine-rich repeat	183..204	CDD:275380	9/20 (45%)
		LRR_8	203..263	CDD:290566	19/88 (22%)
		leucine-rich repeat	205..228	CDD:275380	8/34 (24%)
		leucine-rich repeat	229..252	CDD:275380	7/39 (18%)
		LRR_8	252..311	CDD:290566	23/60 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/23 (35%)
		LRR_8	299..359	CDD:290566	18/60 (30%)
		leucine-rich repeat	301..324	CDD:275380	9/23 (39%)
		leucine-rich repeat	325..348	CDD:275380	3/22 (14%)
		LRR_RI	327..567	CDD:238064	26/100 (26%)
		leucine-rich repeat	349..371	CDD:275380	7/22 (32%)
		LRR_8	370..425	CDD:290566	16/56 (29%)
		leucine-rich repeat	372..393	CDD:275380	9/26 (35%)
		leucine-rich repeat	394..415	CDD:275380	7/26 (27%)
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP012317	XP_320227.3	leucine-rich repeat	74..92	CDD:275380	3/30 (10%)
		LRR_8	92..151	CDD:290566	21/83 (25%)
		LRR_RI	<93..>177	CDD:238064	32/113 (28%)
		leucine-rich repeat	93..116	CDD:275380	6/29 (21%)
		LRR_4	117..155	CDD:289563	15/38 (39%)
		leucine-rich repeat	117..140	CDD:275380	8/22 (36%)
		LRR_8	139..206	CDD:290566	22/72 (31%)
		leucine-rich repeat	141..164	CDD:275380	9/22 (41%)
		leucine-rich repeat	165..195	CDD:275380	8/34 (24%)
		leucine-rich repeat	217..236	CDD:275380	1/18 (6%)
		LRR_8	235..295	CDD:290566	22/59 (37%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..285	CDD:275380	8/23 (35%)
		leucine-rich repeat	342..354	CDD:275378	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910