DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and TOLL6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_320172.2	Gene:	TOLL6 / 1280328	VectorBaseID:	AGAP012387	Length:	1459	Species:	Anopheles gambiae

Alignment Length:	1436	Identity:	293/1436 - (20%)
Similarity:	465/1436 - (32%)	Gaps:	473/1436 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 LP-NEVVVLDLGNNNLT---KLEANSFFMAP--NLEELTLSDNSII----NMDPNAFYGLAKLKR 231
            || |||   ||..|..|   :.:..:|.:.|  :...|::..|..|    .:.||:|..||:||.
Mosquito    60 LPGNEV---DLACNLRTVNSEFDNTNFSVIPAEHTAALSILCNEAIMARSKLLPNSFVHLARLKA 121

  Fly   232 LSLQNCGLKSLPPQSFQGLAQLTSLQLNGNAL------VSLDGDCLGHLQKLRTLRLEGNLFYRI 290
            |||:.|.:.........||..|.:..|..:.:      :.::.|..|..:.|..|.|..|..:.:
Mosquito   122 LSLEFCKIAKFSSTVLAGLGDLRNFTLRTHNIAWPELNLEIEADAFGQTRNLEVLDLSTNNIWSL 186

  Fly   291 PTNALAGLRTLEALNLGSNLLTIIND-----------------------------------EDFP 320
            |.:....|..|.:||:.||.|..:||                                   ||..
Mosquito   187 PDHLFCSLSGLRSLNISSNRLQDVNDLGFREKGVKDEVESEGHKTNSSGSVAPPVSCALDLEDLD 251

  Fly   321 RMPNLIVLL-------LKR--------NQIMKISAGALKNLTALKVLELDDNLISSLPEGL---- 366
            ...|..|||       |||        |:|..:...||..|..|::|:|..|.:.:||..|
Mosquito   252 VSRNHFVLLPAAGFGMLKRLKMLKIHDNEISMVGDKALSGLKELQILDLSSNKLVALPTDLFRDP 316

  Fly   367 ----------------------SKLSQLQELSITSNRL--RWIND-------------------T 388
                                  |||.|||.|.::.|:|  .|:|.                   |
Mosquito   317 AQSIQEIYLQNNSISVLSPGLFSKLEQLQALDLSQNQLTSAWVNRDTFAGLIRLVLLNLASNKIT 381

  Fly   389 ELPR-------SMQMLDMRANPLSTISPGAFRGMSKLRKLILS--DVRTLRSFPELEACHALEIL 444
            :|..       ::|:|::|.|.|..|:...|..|:.|..|:||  .::.|.:: .|...:||.:|
Mosquito   382 KLESEIFSDLYTLQILNLRHNQLEIIAADTFSPMNNLHTLLLSHNKLKYLDAY-SLNGLYALSLL 445

  Fly   445 KLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGL 508
            .||...:..|.....|....|:.|.|..|.|.::| .|...|.||.:||..|.|..|:...|.|:
Mosquito   446 SLDNNALTGVHPEAFRNCSSLQDLNLNGNELTQVPLALKDMRLLRTVDLGENSISVIEEPGFRGM 510

  Fly   509 KQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNN------ 567
            ..|..|.|..|.|:.:.:.||:.:|.||:|::..|:||||.|.||....:::.:.|..|
Mosquito   511 NNLYGLRLISNNIENITRKAFKDLPSLQILNVARNKISYIEKGAFEPAVSVQAIRLDGNLLSDID 575

  Fly   568 -IFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTL--------ILSYAYHCCAFLPLVAM 623
             :|..:|.     |:.|...:| ||..|......|.:|.|        .|:..|.....|.|..:
Mosquito   576 GLFTSMPN-----LVWLNISDN-KLEHFDYSHIPPHLQWLDLHRNELTELTNRYGLDNQLHLQTL 634

  Fly   624 -SSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQ 687
             :|..:.::|..|.: |:..|| :.|.:|.::::.|........|         |.::....||
Mosquito   635 DASFNRLTRVTPATI-PNSIEF-LFLNDNLIVHVEPHCFTHKTNL---------TRVDLYANQL- 687

  Fly   688 TQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFD 752
              |...|....::...|:..:                   .:|..|.       .||: |....|
Mosquito   688 --TSLDIKALRLQPVPEDKQI-------------------PEFYIGG-------NPFV-CDCNID 723

  Fly   753 WWTLRCGVWVVFLLSLLGN------------GTVVFVLLCSRSKMDVP-------RFL------- 791
            |            |..:.:            .||...|:.:|.:..:|       .||
Mosquito   724 W------------LQKINHVTSRQYPTINDIETVYCKLMYNRERSYIPLIEAEPKHFLCSYNTHC 776

  Fly   792 -----VCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL-CQLSGFLAVLSS------ 844
                 .|...|.|..|..........|.:           |..::: |..:|:..:.::
Mosquito   777 FALCHCCEFDACDCEMTCPNNCACYHDNS-----------WSTNIVECSAAGYTDIPNNIPMDTT 830

  Fly   845 ----------ELSVYTLAVITLERNYAITHAIHLN------------KRLS---LKQAGYIMSVG 884
                      |||.::...   .:|..:.:|.|.|            :||:   |:........|
Mosquito   831 EVYIDGNNLVELSGHSFIG---RKNLRVLYANHSNIEAIYNTTFIGLRRLTILHLENNAIRKLYG 892

  Fly   885 WVFALIMALMPL-------VGVSDY-----RKFAV-------CLPFETTTGPASLTYVISLMFIN 930
            ..|:.:.:|..|       ..:.|:     ||..|       ...||.....|: .|::.:...|
Mosquito   893 HEFSALESLRELYLQGNRIAYIEDHTFAELRKLEVLRLDGNRITSFEVWQLSAN-PYLVEIALAN 956

  Fly   931 G-----CAFLTLMGCYL-----KMYWAIRGSQAWNT-------NDSRIAKR--MALLV----FTD 972
            .     |.|:..:..||     |:..|...|.::|.       |.::...|  |:.:|    ..|
Mosquito   957 NLWTCDCGFVNKLRSYLQSNADKIVDANEISCSYNNATSILRDNGTKCTFREGMSSIVHRQEIED 1021

  Fly   973 FLCWSPIAFFSITAIFGLQLISLEQAKIFTVF-------VLPLNSCC-------NPF-------- 1015
            .|....:|..:....|||         ||.:|       |...:..|       |.:
Mosquito  1022 MLPLLLVATCAFVGFFGL---------IFGIFCYRKELKVWVHSGLCYKSGTFVNEYDKDRLYDA 1077

  Fly  1016 --LYAIMTKQFKKDCVT----------LCKHFEE--------SRVVGGGGPGGRGAVARTKR--- 1057
              .|::..:.|....:|          ||.|:.:        ..:|.......|..:..:|.
Mosquito  1078 YITYSLQDEHFVSQILTSTLENDIGFRLCLHYRDLNANAYLADTIVEAVESSKRAILVLSKSFLY 1142

  Fly  1058 ---------------------------GDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQT 1095
                                       ||||...|.|....:.....|:        .|    ..
Mosquito  1143 NEWTRFEFKGAIHEVLKRRRKLIIILYGDLPQRDLDADMRLYLRTNTCI--------EW----DD 1195

  Fly  1096 PSMWQRLRTFCCGENRRRRKQRRQPQQRRQRAYT--------AAAANPYQYQFAELRQQRQNRAS 1152
            ...||:||.             ..|..::.....        |.|.|.|         ....|.|
Mosquito  1196 KKFWQKLRI-------------ALPHVKKSNCLNKRSAINIYATAGNDY---------NTPGRPS 1238

  Fly  1153 SISSENFCSSRSSSWRHGPPSSAPVPPGNCS-----MPLKMLEPHAHPHGHGRR----------- 1201
            ::......:.......|...:..|..|.||.     ...|......|...|.||
Mosquito  1239 TLGPSVASTRLDGPQHHSYATIGPNCPRNCDNYDTVSNCKYNTTQHHQTHHERRTTADFGRKATD 1303

  Fly  1202 -RHSAWLI--------TRKTSQDSNLSSSRNDSSASATTASTSTFRLSRSSAGSSTPLPSIIAHN 1257
             |...:.:        |.:|...:..|..|........|:::|.|..|...:||.:...||   :
Mosquito  1304 GRQHEYAVPSNCLLDTTHETYNTTATSCERIAGETFECTSTSSKFSTSSRGSGSDSGSHSI---S 1365

  Fly  1258 GKAQLD 1263
            ..||.|
Mosquito  1366 SAAQHD 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/2 (100%)
		LRR_RI	180..>383	CDD:238064	72/295 (24%)
		leucine-rich repeat	183..204	CDD:275380	6/25 (24%)
		LRR_8	203..263	CDD:290566	19/65 (29%)
		leucine-rich repeat	205..228	CDD:275380	7/26 (27%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	15/64 (23%)
		leucine-rich repeat	253..276	CDD:275380	4/28 (14%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	26/109 (24%)
		leucine-rich repeat	301..324	CDD:275380	10/57 (18%)
		leucine-rich repeat	325..348	CDD:275380	11/37 (30%)
		LRR_RI	327..567	CDD:238064	89/311 (29%)
		leucine-rich repeat	349..371	CDD:275380	10/47 (21%)
		LRR_8	370..425	CDD:290566	22/84 (26%)
		leucine-rich repeat	372..393	CDD:275380	9/48 (19%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	20/70 (29%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	21/57 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	18/62 (29%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	4/27 (15%)
		7tm_4	764..>892	CDD:304433	28/190 (15%)
		7tm_1	770..1017	CDD:278431	62/375 (17%)
TOLL6	XP_320172.2	LRR_RI	94..355	CDD:238064	63/260 (24%)
		leucine-rich repeat	119..142	CDD:275380	8/22 (36%)
		LRR_8	<162..207	CDD:290566	13/44 (30%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	247..305	CDD:290566	18/57 (32%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		leucine-rich repeat	271..294	CDD:275380	5/22 (23%)
		LRR_8	293..354	CDD:290566	15/60 (25%)
		leucine-rich repeat	295..319	CDD:275380	7/23 (30%)
		LRR_RI	298..549	CDD:238064	70/251 (28%)
		leucine-rich repeat	320..343	CDD:275380	3/22 (14%)
		leucine-rich repeat	344..369	CDD:275380	7/24 (29%)
		LRR_8	369..428	CDD:290566	14/58 (24%)
		leucine-rich repeat	370..393	CDD:275380	2/22 (9%)
		leucine-rich repeat	394..417	CDD:275380	8/22 (36%)
		LRR_8	417..476	CDD:290566	17/59 (29%)
		leucine-rich repeat	418..441	CDD:275380	6/23 (26%)
		leucine-rich repeat	442..465	CDD:275380	6/22 (27%)
		leucine-rich repeat	466..488	CDD:275380	7/21 (33%)
		leucine-rich repeat	489..512	CDD:275380	9/22 (41%)
		LRR_8	512..571	CDD:290566	21/58 (36%)
		leucine-rich repeat	513..534	CDD:275380	7/20 (35%)
		leucine-rich repeat	537..560	CDD:275380	11/22 (50%)
		LRR_8	560..616	CDD:290566	13/61 (21%)
		leucine-rich repeat	561..583	CDD:275380	3/21 (14%)
		LRR_8	630..687	CDD:290566	12/67 (18%)
		leucine-rich repeat	631..676	CDD:275380	10/46 (22%)
		leucine-rich repeat	829..852	CDD:275380	3/25 (12%)
		LRR_8	851..911	CDD:290566	11/59 (19%)
		LRR_RI	<852..962	CDD:238064	20/110 (18%)
		leucine-rich repeat	853..876	CDD:275380	3/22 (14%)
		leucine-rich repeat	877..900	CDD:275380	4/22 (18%)
		LRR_8	900..958	CDD:290566	11/58 (19%)
		leucine-rich repeat	901..924	CDD:275380	3/22 (14%)
		TIR	1075..1208	CDD:214587	21/157 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910