DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP011371

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_317948.4	Gene:	AgaP_AGAP011371 / 1278325	VectorBaseID:	AGAP011371	Length:	320	Species:	Anopheles gambiae

Alignment Length:	348	Identity:	86/348 - (24%)
Similarity:	140/348 - (40%)	Gaps:	95/348 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LTLSDNSIINMDPN-AFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCL 271
            |.:..|.|.::|.: .||  .:|..|.|....|.|:|.:.|....:|..|.||.|.|.::.....
Mosquito     2 LVIKFNRIKSIDSSIQFY--TELTMLDLSYNHLLSIPERIFMYQKKLLQLHLNNNKLGAVTNRTF 64

  Fly   272 GHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIV--LLLKRNQ 334
            |.|.:||.|.|.||....|.:.....|..||.||||.|.:..::...|..:.||.:  |.:..:.
Mosquito    65 GGLDELRVLNLRGNFIDEIGSELFKALPKLEELNLGQNRIATLHASAFDGLANLRLRRLDIHGSM 129

  Fly   335 IMKISAGALKNLTALKVLELDDNLISSLPE-GLSKLSQLQELSITSNRLRWINDTELPRSMQMLD 398
            ::.|::...:.|..::.|:|.||.:..:|. .||.|.:|:||:|..      ||.|
Mosquito   130 LVNITSDTFRGLENIRSLDLSDNHLLKVPTVQLSGLKRLEELTIGQ------NDFE--------- 179

  Fly   399 MRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTP 463
                   ||..|||.|:|.|:.:.:|....||
Mosquito   180 -------TIPEGAFFGLSNLKSIDISGALNLR--------------------------------- 204

  Fly   464 RLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDA 528
                 ::::.:....|||.|      :.::||:                :||       .|.:.|
Mosquito   205 -----QVQSGAFSANPNLES------ITIASNK----------------ELL-------ELDEGA 235

  Fly   529 FQGIPKLQLLDLEGNEISYIHKE 551
            |.|:|.::.:.|..|:|:..|:|
Mosquito   236 FAGLPHIRKVSLRDNKIATFHEE 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	54/178 (30%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	18/55 (33%)
		leucine-rich repeat	205..228	CDD:275380	6/20 (30%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	23/58 (40%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	17/61 (28%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	4/24 (17%)
		LRR_RI	327..567	CDD:238064	47/228 (21%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	15/54 (28%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	8/67 (12%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	11/57 (19%)
		leucine-rich repeat	487..510	CDD:275380	2/22 (9%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	6/19 (32%)
		leucine-rich repeat	535..558	CDD:275380	5/17 (29%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP011371	XP_317948.4	leucine-rich repeat	1..21	CDD:275380	6/20 (30%)
		LRR_8	20..78	CDD:290566	19/57 (33%)
		LRR_RI	<22..156	CDD:238064	40/133 (30%)
		leucine-rich repeat	22..45	CDD:275380	7/22 (32%)
		leucine-rich repeat	46..69	CDD:275380	8/22 (36%)
		LRR_8	69..130	CDD:290566	19/60 (32%)
		leucine-rich repeat	70..93	CDD:275380	8/22 (36%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		leucine-rich repeat	120..143	CDD:275380	3/22 (14%)
		LRR_8	143..199	CDD:290566	23/77 (30%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		LRR_5	168..>250	CDD:290045	32/170 (19%)
		leucine-rich repeat	168..191	CDD:275380	13/44 (30%)
		leucine-rich repeat	192..216	CDD:275380	4/61 (7%)
		leucine-rich repeat	217..241	CDD:275380	10/52 (19%)
		leucine-rich repeat	242..260	CDD:275380	5/17 (29%)
		LRRCT	273..320	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910