DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and AgaP_AGAP005496

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_315493.3	Gene:	AgaP_AGAP005496 / 1276179	VectorBaseID:	AGAP005496	Length:	485	Species:	Anopheles gambiae

Alignment Length:	403	Identity:	88/403 - (21%)
Similarity:	145/403 - (35%)	Gaps:	109/403 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 AGALKNLTALKVLELDDNLISSLPEGL-SKLSQLQELSITSNRLRWINDTEL---PRSMQMLDMR 400
            |||..::|.:|   ..|:.:.:||..| ....|||||     |:.|::...:   ||.:. ||..
Mosquito    59 AGAAADVTRVK---FRDSSMVALPSSLYGAFRQLQEL-----RVWWMHLHSIHIDPRLLS-LDAE 114

  Fly   401 ANPLSTIS--PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTP 463
            .|.:|:|:  ||.                                                  .|
Mosquito   115 KNRISSITTEPGT--------------------------------------------------VP 129

  Fly   464 RLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDA 528
            .|:.|||..|.|:.|.|:|...:|.:|:|:.|.:..:....|..:.:|..|.||.|.: ||.:.:
Mosquito   130 LLRKLELNQNRLRNIDNISVFENLEVLELAHNDLRTLDLCVFQRMPKLRLLDLSSNNL-ALVRSS 193

  Fly   529 F--QGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKL 591
            .  :.:..|.:|.|..|.::|:.......|.|||.::|.||....:....|..:|       |:|
Mosquito   194 IGAEKLASLTVLYLNDNRLTYLDLSILRSFPALEKVHLANNALVYVDHDSLPTML-------PRL 251

  Fly   592 REFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQ---------------EAVLFPSD 641
            |.|       .:||    ..:||.....|:   .|.:.:.||               |.:....:
Mosquito   252 RVF-------HLQT----NDWHCEGLAELI---GQLRKTGVQDFKTFSAFSCKERMVEGICCTEN 302

  Fly   642 AEFDMTLWNNSMMNIWPQMHN-----LSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEE 701
            ..|.:...:|..:..:....|     |.::|..:.|:......|.|..|:..|..|........:
Mosquito   303 KPFALVRKSNQYLASYTSELNGHTRHLMRELQHTRHEVARLIANDNYTQVSLQNIGDEVEELRNQ 367

  Fly   702 YFEEHDVSGPATG 714
            ..:......|.||
Mosquito   368 LTDALSSPDPVTG 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	15/43 (35%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	6/18 (33%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	3/7 (43%)
		LRR_RI	327..567	CDD:238064	57/234 (24%)
		leucine-rich repeat	349..371	CDD:275380	5/22 (23%)
		LRR_8	370..425	CDD:290566	16/59 (27%)
		leucine-rich repeat	372..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..486	CDD:275380	10/67 (15%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	16/59 (27%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	7/24 (29%)
		LRR_8	533..589	CDD:290566	14/55 (25%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP005496	XP_315493.3	leucine-rich repeat	108..123	CDD:275380	5/15 (33%)
		LRR_RI	<129..275	CDD:238064	46/167 (28%)
		LRR_8	129..187	CDD:290566	20/57 (35%)
		LRR_4	131..167	CDD:289563	13/35 (37%)
		leucine-rich repeat	131..152	CDD:275380	9/20 (45%)
		leucine-rich repeat	153..176	CDD:275380	5/22 (23%)
		LRR_8	175..236	CDD:290566	19/61 (31%)
		leucine-rich repeat	177..201	CDD:275380	7/24 (29%)
		LRR_4	201..>236	CDD:289563	12/34 (35%)
		leucine-rich repeat	202..225	CDD:275380	6/22 (27%)
		leucine-rich repeat	226..250	CDD:275380	7/30 (23%)
		Kinesin_assoc	329..>443	CDD:292801	11/52 (21%)
		MreC	401..>468	CDD:302802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910