DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and PODN

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_016855783.1	Gene:	PODN / 127435	HGNCID:	23174	Length:	652	Species:	Homo sapiens

Alignment Length:	639	Identity:	158/639 - (24%)
Similarity:	252/639 - (39%)	Gaps:	158/639 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QLLLQLLLLPPS----------------AMGHDETKENPAPDMQNSQEQEPYVHLQHLQQQQQQN 67
            ::||.||||||.                :.||     :.:|:.....|:||.:.|.  .::....
Human    44 RVLLLLLLLPPQLHLGPVLAVRAPGFGRSGGH-----SLSPEENEFAEEEPVLVLS--PEEPGPG 101

  Fly    68 PQTVQQLSQITVNRTSKSASVTPTGI--RENVMLPSADPE---------KEAQILYEKSLQEYHG 121
            |..|.......   .|:...|...||  ||   .|...||         .:.:.:|.:.|...|
Human   102 PAAVSCPRDCA---CSQEGVVDCGGIDLRE---FPGDLPEHTNHLSLQNNQLEKIYPEELSRLH- 159

  Fly   122 SQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDL 186
             :|.|.:...:    :.|...:.|:..:   |.| :|..|.|:...:.:  .|..|||.::.:|.
Human   160 -RLETLNLQNN----RLTSRGLPEKAFE---HLT-NLNYLYLANNKLTL--APRFLPNALISVDF 213

  Fly   187 GNNNLTKLEANSFFMAPNLEELTLSDNSIIN--MDPNAFYGLAK--------------------- 228
            ..|.|||:...:|...|||..:.|.:|.:.:  :..|.|.|.:.
Human   214 AANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPA 278

  Fly   229 LKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV--SLDGDCLGHLQKLRTLRLEGNLFYRIP 291
            |.:|.|:|..|:.:||.:|..|:.|..|.|..|.|.  .||.:....|..|..|.|..|...|:|
Human   279 LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 343

  Fly   292 TNALAGL-RTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMK--ISAGALKNLTALKVLE 353
                ||| |:|..|:|..|.:..::......:.:|..|||..||:.:  |...|.:.|..|..:.
Human   344 ----AGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVH 404

  Fly   354 LDDNLISSLPEGL------------------------------------------------SKLS 370
            |.:|.:..:|.||                                                .||.
Human   405 LYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 469

  Fly   371 QLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPEL 435
            .|:.|.::.|||..: ...|||::.:|.::.|.|:.::.||..||::||:|.|:..| |||
Human   470 LLRSLDLSGNRLHTL-PPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNR-LRS---- 528

  Fly   436 EACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKI 500
               .||.    .||.:         ....|:.|::..|.|..||. .....|..|.|.:|:|..:
Human   529 ---RALG----PRAWV---------DLAHLQLLDIAGNQLTEIPE-GLPESLEYLYLQNNKISAV 576

  Fly   501 QGKPFNGLKQLNDLLLSYNR--IKALPQDAFQGIPKLQLLDLEGN-EISYIHKE 551
            ....|:....|..:.|.:|:  :.::...||:.:..||:||:||| |...|.|:
Human   577 PANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKD 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	66/278 (24%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	21/82 (26%)
		leucine-rich repeat	205..228	CDD:275380	6/24 (25%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	22/61 (36%)
		leucine-rich repeat	253..276	CDD:275380	8/24 (33%)
		leucine-rich repeat	277..300	CDD:275380	9/23 (39%)
		LRR_8	299..359	CDD:290566	17/61 (28%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	9/24 (38%)
		LRR_RI	327..567	CDD:238064	70/278 (25%)
		leucine-rich repeat	349..371	CDD:275380	8/69 (12%)
		LRR_8	370..425	CDD:290566	19/54 (35%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	18/67 (27%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	18/60 (30%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	5/24 (21%)
		LRR_8	533..589	CDD:290566	10/20 (50%)
		leucine-rich repeat	535..558	CDD:275380	10/18 (56%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
PODN	XP_016855783.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910