DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and GPRGHP1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_003436383.1	Gene:	GPRGHP1 / 1273750	VectorBaseID:	AGAP003076	Length:	636	Species:	Anopheles gambiae

Alignment Length:	670	Identity:	129/670 - (19%)
Similarity:	242/670 - (36%)	Gaps:	209/670 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 MHNLSKQLGAS------------------MHDPWE---TAINFNEEQLQTQTGGQIATSYMEEY- 702
            |..||..:|:|                  :||..:   |.::.:::|.|..........|..:|
Mosquito     1 MMELSPTVGSSGSLLDALITNGTNGRTGLLHDILDGHRTLLHQSQQQQQQHYNHPHHQQYQPQYL 65

  Fly   703 FEEHDVSG---PATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVF 764
            :....::|   .:..||          |:..      |:.:|.....|              .:|
Mosquito    66 YANESLAGSVPESASYG----------TDSI------CIILPITIFYC--------------FIF 100

  Fly   765 LLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQM 829
            :..::||.::..|:..::|......:.:.|||.:||.:     :|..:.....|.:..||.|:.
Mosquito   101 VAGIVGNLSICVVIAKNKSMHTATNYYLFNLAVSDFLL-----LLFGMPQELYGTWNPFAYPFN- 159

  Fly   830 SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALM 894
            .:.|.:.|.|:..::..:|.|:...|:||..||.|....:....|.:|...:.|.|:.|..:|..
Mosquito   160 QIACIIMGLLSETAANATVLTITSFTVERYIAICHPFRSHTMSKLSRAIKFVIVIWLVAFGLATP 224

  Fly   895 PLV--GVSDYRKFAVCL--------PFETTT-----GPASLTYVISLMFINGCAFLTLMGCYLKM 944
            ..:  ||.:.....:|.        .||.::     ||.:|   |:::::       |:|..|:.
Mosquito   225 QALQFGVVETNTTRLCTIKNEHFSHAFEVSSFLFFVGPMTL---IAVLYV-------LIGIKLRK 279

  Fly   945 YWAIRGSQAWNTN----------DSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAK 999
            ...::|.:..:::          .||:.:.:..:|.|.|:||:|.....:.|::|: ....|...
Mosquito   280 SKLLQGVKRASSDYTTPPRGISAQSRVIRMLVAVVATFFICWAPFHAQRLMAVYGV-FSKTENVF 343

  Fly  1000 IFTVFVLP---------LNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVART 1055
            .:.|:::.         |::|.||.||.||:.:|:    ...:|..:....||          :.
Mosquito   344 FYKVYMVLNYTSGILYFLSTCINPLLYNIMSHKFR----DASRHTLKMSCCGG----------KR 394

  Fly  1056 KRGDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCC----------GEN 1110
            .:.|.......|.:.....||...::..:.|                   .|          |.|
Mosquito   395 SKSDGQHHTYSAVSRYGVTGCGSFKVNSNNM-------------------ACIGTGIGLGTGGGN 440

  Fly  1111 RRRRKQRRQPQQRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSENFCSSRSSSWRHGPPSSA 1175
            ...::|.:||.       ...:|.|.|.       |:::..|.:::|: |:
Mosquito   441 AASKQQHQQPG-------NGTSATPNQC-------QQESNMSLLANES-CN-------------- 476

  Fly  1176 PVPPGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLSSSRNDSSASATTASTSTFRLS 1240
                 ..:||...:.|               ..||..|...::|||:   |.:.|..| |..:||
Mosquito   477 -----RGTMPPIAIRP---------------TFTRADSHCISISSSQ---STTGTNVS-SNGKLS 517

  Fly  1241 RSSAGSSTPLPSIIAHNGKA 1260
            |||.||       :.|.|.|
Mosquito   518 RSSNGS-------LRHGGSA 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	31/127 (24%)
		7tm_1	770..1017	CDD:278431	60/280 (21%)
GPRGHP1	XP_003436383.1	7tm_4	90..>291	CDD:304433	47/230 (20%)
GPRGHP1	XP_003436383.1	7tm_1	106..370	CDD:278431	60/280 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910