DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP000054

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_311104.5	Gene:	AgaP_AGAP000054 / 1272222	VectorBaseID:	AGAP000054	Length:	1593	Species:	Anopheles gambiae

Alignment Length:	633	Identity:	172/633 - (27%)
Similarity:	256/633 - (40%)	Gaps:	162/633 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 NLPNEVVVLDLGNNNLTK--LEAN-------SFFMAPNLEELTLSDNSIINM--DPNAFYGLAKL 229
            |:|.|:...   :|:|.:  |:||       .||....|.:|.||||.||.:  |...|..|.:|
Mosquito    27 NVPEEIFRY---SNSLEELLLDANHIRDLPKGFFRLYRLRKLGLSDNDIIKIPSDIQNFVNLVEL 88

  Fly   230 --------------KRL-SLQNCGLKSLP----PQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQ 275
                          |.| |||.....|.|    |..|..|..||.|.||..:|:||..| .|.|.
Mosquito    89 DVSRNEIGDIPEDIKHLRSLQIADFSSNPISRLPAGFTQLRNLTVLGLNDMSLISLPQD-FGCLS 152

  Fly   276 KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPR----MPNLIVLLLKRNQIM 336
            ||.:|.|..||...:| .:::.|..||.|:||.|.:     ::.|.    :|:|..|.|..||::
Mosquito   153 KLVSLELRENLLKNLP-ESISQLTKLERLDLGDNEI-----DELPSHVGYLPSLQELWLDHNQLL 211

  Fly   337 KI--SAGALKNLTALKV--------------------LELDDNLISSLPEGLSKLSQLQELSITS 379
            ::  ..|.||.|..|.|                    |.|..||:.:||.|:|||:.|..|.:..
Mosquito   212 RLPPEIGLLKKLVCLDVSENRLEELPEEIGGLECLTDLHLSQNLLETLPNGISKLTNLSILKLDQ 276

  Fly   380 NRLRWINDT-ELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEI 443
            |||..:||: .....||.|.:..|.||.: |.....|     |:|::
Mosquito   277 NRLHTLNDSIGCCVHMQELILTENFLSEL-PATVGNM-----LVLNN------------------ 317

  Fly   444 LKLDRAGIQEVPANL--CRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPF 505
            |.:||..:..||:.|  |||   |..|.|:.|.|.|:| .|.:|.:|.:||:|.|.::.:   |:
Mosquito   318 LNVDRNSLVAVPSELGNCRQ---LGVLSLRENKLTRLPAELGNCGELHVLDVSGNLLQHL---PY 376

  Fly   506 NGLK-QLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIF 569
            :.:. ||..:.||.|:.:.:|  .||  |.   :|...||      :..:.|           :.
Mosquito   377 SLVNLQLKAVWLSENQSQPVP--TFQ--PD---VDETTNE------QVLTCF-----------LL 417

  Fly   570 PE---LPESGLRALLHLKTFNNPKLREFPPPDTF-----PRIQTLILSYAYHCCAFLPLVAMSS- 625
            |:   :|             :||..||....:.:     .|..::..:..:......|.|..::
Mosquito   418 PQQRYVP-------------SNPSQREDTDSENWEEREASRTHSVKFTEDFGADRDTPFVRQNTP 469

  Fly   626 QKKTSQVQEAVLFPSDAEFD------MTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEE 684
            ..|..:::...||..:.:.|      .||...|...  |.:.|.|....|:|.|....||..:||
Mosquito   470 HPKELKMKAHKLFAKERKSDDLSGNLDTLSEESASR--PSLLNRSGYGTATMEDIQGHAIPHDEE 532

  Fly   685 QLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQP 732
            |.:...|...|...:|...::.|      ||....| |.....||..|
Mosquito   533 QGEAAAGSAEAGGGVEGAQDDED------GYEKRVG-FEVNEDEDDDP 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	1/2 (50%)
		LRR_RI	180..>383	CDD:238064	82/258 (32%)
		leucine-rich repeat	183..204	CDD:275380	7/29 (24%)
		LRR_8	203..263	CDD:290566	27/80 (34%)
		leucine-rich repeat	205..228	CDD:275380	11/24 (46%)
		leucine-rich repeat	229..252	CDD:275380	11/41 (27%)
		LRR_8	252..311	CDD:290566	25/58 (43%)
		leucine-rich repeat	253..276	CDD:275380	11/22 (50%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	22/85 (26%)
		leucine-rich repeat	301..324	CDD:275380	7/26 (27%)
		leucine-rich repeat	325..348	CDD:275380	9/24 (38%)
		LRR_RI	327..567	CDD:238064	74/266 (28%)
		leucine-rich repeat	349..371	CDD:275380	12/41 (29%)
		LRR_8	370..425	CDD:290566	17/55 (31%)
		leucine-rich repeat	372..393	CDD:275380	7/21 (33%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	20/70 (29%)
		leucine-rich repeat	441..464	CDD:275378	9/24 (38%)
		LRR_8	487..545	CDD:290566	17/58 (29%)
		leucine-rich repeat	487..510	CDD:275380	6/23 (26%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	7/58 (12%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	2/23 (9%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP000054	XP_311104.5	leucine-rich repeat	16..38	CDD:275380	3/13 (23%)
		LRR_RI	23..259	CDD:238064	74/241 (31%)
		LRR_8	38..95	CDD:290566	18/56 (32%)
		leucine-rich repeat	39..58	CDD:275380	5/18 (28%)
		leucine-rich repeat	62..84	CDD:275380	10/21 (48%)
		LRR_8	84..138	CDD:290566	16/53 (30%)
		leucine-rich repeat	85..107	CDD:275380	4/21 (19%)
		leucine-rich repeat	108..130	CDD:275380	7/21 (33%)
		leucine-rich repeat	131..176	CDD:275380	19/46 (41%)
		LRR_8	152..210	CDD:290566	20/63 (32%)
		leucine-rich repeat	177..199	CDD:275380	7/26 (27%)
		LRR_8	198..256	CDD:290566	15/57 (26%)
		leucine-rich repeat	200..222	CDD:275380	7/21 (33%)
		leucine-rich repeat	223..245	CDD:275380	3/21 (14%)
		LRR_8	246..300	CDD:290566	20/53 (38%)
		leucine-rich repeat	246..268	CDD:275380	10/21 (48%)
		LRR_8	315..371	CDD:290566	24/76 (32%)
		leucine-rich repeat	315..337	CDD:275380	8/39 (21%)
		leucine-rich repeat	361..382	CDD:275380	6/23 (26%)
		PDZ	766..854	CDD:214570
		PDZ_signaling	943..1032	CDD:238492
		PDZ_signaling	1139..1228	CDD:238492
		PDZ_signaling	1238..1327	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910