DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and AgaP_AGAP000360

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_310751.5	Gene:	AgaP_AGAP000360 / 1271896	VectorBaseID:	AGAP000360	Length:	1451	Species:	Anopheles gambiae

Alignment Length:	697	Identity:	185/697 - (26%)
Similarity:	269/697 - (38%)	Gaps:	144/697 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GSLEVLRL------SCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNS 214
            |:|..||.      :.:.:|..|:...||  |..::|...|||:||..:|....||.||||.:|.
Mosquito   728 GALHGLRTLDLSYNNLQTLGADALQPGLP--VASVNLRGCNLTRLEPGAFRGLLNLAELTLEENR 790

  Fly   215 I---------------INMDPNAFYG--------LAKLKRLSLQNCGLKSLPPQSFQGLAQLTSL 256
            :               :.:..|.|..        |..|:.|.|..|.:..||....|....|..|
Mosquito   791 LPAGELRHLDASPVRTLRLADNNFTAVREGLLDRLVSLQVLELARCAIGDLPTALLQRNVNLVRL 855

  Fly   257 QLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPR 321
            .|:.|.|..|.......|...:.|||.||.....|..||..:.|||.|.|..|.||.|:......
Mosquito   856 DLSENELRVLRRGSFAGLHVFKELRLHGNRLADFPHLALLNVSTLEVLTLSRNQLTAIDFYKLSG 920

  Fly   322 MPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLS-QLQELSITSNRLRWI 385
            :|||..|.|..|.|..:.......|..|..|:|..||:.:|||...|.| .||.:.:::||...|
Mosquito   921 LPNLRTLDLHANSITTLGGFTADTLPHLDTLDLSGNLLLALPENFFKHSVSLQRVDLSANRFGRI 985

  Fly   386 NDTELPRS----MQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKL 446
            .:..|..:    :..|::..|||..||..|.:                :.||.|..      |.:
Mosquito   986 PNLALSEASLARLAWLNLTGNPLQRISADADQ----------------QRFPHLRE------LVI 1028

  Fly   447 DRAGIQEVPANLCRQTPRLKSLELKTNSLKRI-PN-LSSCRDLRLLDLSSNQIEKIQGKPFNGLK 509
            .|..:..|.:......|.::.|.|..|.:.|| |. ..:...|:|||||.|::|.:..:...||:
Mosquito  1029 SRTNLSIVTSKDFELYPAVQRLHLAHNRINRISPGAFVALASLQLLDLSVNELELLPKERLQGLR 1093

  Fly   510 QLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNL-GNNIFPELP 573
            .|..|.||.|.|:.|.:.| |.:.||::||...|::..|||.|.....||::|.| ||.:.....
Mosquito  1094 LLETLNLSTNSIRELDEFA-QDLQKLRVLDASANQLERIHKNALRHLGALQELYLNGNRLITVAS 1157

  Fly   574 ES--GLRALLHL----KTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQV 632
            ::  .||||..|    ..|....||...|.:|  .:|.|.|.....|...||.:...:..::|..
Mosquito  1158 DAFRTLRALTRLDLRKNYFEYVPLRALKPLET--HLQQLRLEETILCLYPLPQIRGKTMNRSSNS 1220

  Fly   633 QEAVLFPSDAEF-----DMTLW------NNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQL 686
            .:.....|:..:     .:..|      .||::|...|:.|.....|:::|
Mosquito  1221 AKLNRLSSNTRYLICVLGLGSWLTYHSDINSLLNQSNQLQNQILNSGSAVH-------------- 1271

  Fly   687 QTQTGGQIATSYMEEYFEEHDVSGPATGYGFG--------TGLFSGMSTEDFQPGSVQCLPMPGP 743
                                      :||..|        |.|...|.|...:...|:.|...||
Mosquito  1272 --------------------------SGYAAGDLDASLSNTLLSLMMDTPTSRCTEVRTLDAIGP 1310

  Fly   744 FLPCAD---------LFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCS 781
             .|.|:         :....|.|.|:.|...|     |.|||::|.|
Mosquito  1311 -NPLAEADGMSGRSIIHSILTRRLGLIVGCCL-----GIVVFIVLVS 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/26 (23%)
		LRR_RI	180..>383	CDD:238064	71/226 (31%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	21/82 (26%)
		leucine-rich repeat	205..228	CDD:275380	9/45 (20%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	74/247 (30%)
		leucine-rich repeat	349..371	CDD:275380	10/22 (45%)
		LRR_8	370..425	CDD:290566	14/59 (24%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	13/69 (19%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	24/57 (42%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	21/62 (34%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	7/23 (30%)
		7tm_4	764..>892	CDD:304433	7/18 (39%)
		7tm_1	770..1017	CDD:278431	6/12 (50%)
AgaP_AGAP000360	XP_310751.5	leucine-rich repeat	166..188	CDD:275380
		LRR_8	188..247	CDD:290566
		leucine-rich repeat	190..213	CDD:275380
		leucine-rich repeat	214..236	CDD:275380
		LRR_8	236..296	CDD:290566
		leucine-rich repeat	237..261	CDD:275380
		leucine-rich repeat	262..285	CDD:275380
		LRR_RI	267..512	CDD:238064
		leucine-rich repeat	286..310	CDD:275380
		leucine-rich repeat	311..334	CDD:275380
		LRR_8	314..369	CDD:290566
		leucine-rich repeat	335..358	CDD:275380
		LRR_8	358..416	CDD:290566
		leucine-rich repeat	359..382	CDD:275380
		leucine-rich repeat	383..405	CDD:275380
		LRR_8	404..464	CDD:290566
		leucine-rich repeat	406..429	CDD:275380
		leucine-rich repeat	430..453	CDD:275380
		LRR_8	453..512	CDD:290566
		leucine-rich repeat	454..477	CDD:275380
		leucine-rich repeat	478..501	CDD:275380
		LRR_8	501..560	CDD:290566
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..547	CDD:275380
		LRR_RI	548..791	CDD:238064	23/64 (36%)
		leucine-rich repeat	613..636	CDD:275380
		LRR_8	615..671	CDD:290566
		leucine-rich repeat	637..660	CDD:275380
		LRR_8	660..743	CDD:290566	4/14 (29%)
		leucine-rich repeat	661..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..732	CDD:275380	2/3 (67%)
		leucine-rich repeat	733..756	CDD:275380	4/22 (18%)
		LRR_RI	735..1027	CDD:238064	87/315 (28%)
		leucine-rich repeat	757..780	CDD:275380	8/22 (36%)
		leucine-rich repeat	781..803	CDD:275380	6/21 (29%)
		leucine-rich repeat	804..827	CDD:275380	3/22 (14%)
		LRR_8	827..886	CDD:290566	19/58 (33%)
		leucine-rich repeat	828..851	CDD:275380	7/22 (32%)
		leucine-rich repeat	852..875	CDD:275380	7/22 (32%)
		leucine-rich repeat	876..899	CDD:275380	8/22 (36%)
		LRR_8	877..934	CDD:290566	23/56 (41%)
		leucine-rich repeat	900..923	CDD:275380	8/22 (36%)
		LRR_RI	902..1176	CDD:238064	89/296 (30%)
		LRR_8	922..982	CDD:290566	21/59 (36%)
		leucine-rich repeat	924..947	CDD:275380	6/22 (27%)
		leucine-rich repeat	948..968	CDD:275380	8/19 (42%)
		leucine-rich repeat	972..997	CDD:275380	6/24 (25%)
		LRR_8	997..1057	CDD:290566	17/81 (21%)
		leucine-rich repeat	998..1025	CDD:275380	10/42 (24%)
		leucine-rich repeat	1026..1070	CDD:275380	10/43 (23%)
		LRR_8	1045..1105	CDD:290566	22/59 (37%)
		leucine-rich repeat	1071..1094	CDD:275380	10/22 (45%)
		LRR_8	1093..1152	CDD:290566	24/59 (41%)
		leucine-rich repeat	1095..1117	CDD:275380	9/22 (41%)
		leucine-rich repeat	1118..1141	CDD:275380	8/22 (36%)
		LRR_8	1142..1197	CDD:290566	17/56 (30%)
		leucine-rich repeat	1142..1163	CDD:275380	5/20 (25%)
		leucine-rich repeat	1166..1187	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910