DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and GPRFSH

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_309589.2	Gene:	GPRFSH / 1270908	VectorBaseID:	AGAP004035	Length:	959	Species:	Anopheles gambiae

Alignment Length:	742	Identity:	241/742 - (32%)
Similarity:	387/742 - (52%)	Gaps:	96/742 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 ISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQ-MLDMRANPLSTISPGAFRGMSKLRKLI 422
            |..:|:.|:.:.:|....:...|||....|....::| :..:.......|.|.||..:..||.|.
Mosquito   144 IVRVPQKLTGMQRLTLEKVGIKRLRTNALTVYADTLQDLFFIYLREFHRIEPAAFARLRHLRTLY 208

  Fly   423 LSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQ-TPRLKSLELKTNSLKRIPNLSSCRD 486
            ::..      |:||.                :||::... :.|||:|.:..:.|..:|:|....|
Mosquito   209 IAHA------PKLEF----------------LPADVFEGISTRLKTLRIIHSGLLAVPDLRVLSD 251

  Fly   487 ---LRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGN-EISY 547
               :.::||..|||.:|..:... || .::|:|..|.:..:...||.| .::..|.::.| ::..
Mosquito   252 HIIMHMVDLDGNQIREIHERSIQ-LK-TDELILDNNALTEIHGSAFHG-SEIAKLSIKMNYKLKE 313

  Fly   548 IHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAY 612
            ||::||.|.:.:.:|:|......|||..||..|..|:..:...|:..|....|..::|..|::::
Mosquito   314 IHEKAFVGISNIRELDLSGTAIEELPTEGLAELEVLRIQHTHSLKTIPSVYNFKNLRTAYLTHSF 378

  Fly   613 HCCAFL------PLVAMSSQKKTSQVQEAVL------------FPSDAEFDMTLWNNSMMNIWPQ 659
            |||||.      |.....:.||..:||...:            .||.||..:.|..:......|.
Mosquito   379 HCCAFKFPARHDPDAHERNLKKFYEVQHRCIANGYSTPHFKLEVPSSAETPLVLDADGKEGSGPD 443

  Fly   660 MHNLSKQLGASMHDPW-------ETAINFNEEQLQT-QTGGQIATSYMEEYFEEHDVSGPATGY- 715
            ..:.:::.....|  |       ||  |....:..| |.|..::...|.|..::..:. |.||:
Mosquito   444 RTDRNRRSADFRH--WFRLTASDET--NGRSPRTDTLQKGIDLSDKRMGEIVDDSYLL-PITGHP 503

  Fly   716 -------GFGTGLF-------------SGMSTEDFQPGS-------VQCLPMPGPFLPCADLFDW 753
                   ..|.||:             :.:|:.:...|:       |||.|||....||.|:...
Mosquito   504 VDDAGELAIGGGLYTENPLLGEFHETVAQISSMEALCGNLTPMILDVQCYPMPDALNPCEDVMGS 568

  Fly   754 WTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLG 818
            ..||..||||.||::.||..||.||..:||.:.||:||:||||.||..||:||.::|.:||.::|
Mosquito   569 HWLRGSVWVVVLLAVFGNVAVVVVLFSNRSDLTVPKFLICNLAFADLCMGLYLLLIASIDAHSMG 633

  Fly   819 EFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSV 883
            |:..:|..||..|.|:::|||.|.:|.||::||.::||||.:||||||:||:|:.|..|.|||.:
Mosquito   634 EYFNYAFDWQYGVGCKVAGFLTVFASHLSIFTLTIVTLERWFAITHAIYLNRRIKLSAAMYIMII 698

  Fly   884 GWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAI 948
            |||:|:.||.|||.|:|:|...::|||.|.... ..:.|:::::.:|||.|:.::.||.::|.::
Mosquito   699 GWVYAITMASMPLFGISNYSSTSICLPMEARDS-LDIAYLLTVLVVNGCGFVVIVVCYAQIYLSL 762

  Fly   949 -----RGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPL 1008
                 :.:::.::.:..:||:|||||||:|.||:|||||.:|||.|..||.:.::||..||..||
Mosquito   763 GKETRQAARSAHSGEMTVAKKMALLVFTNFACWAPIAFFGLTAIAGYPLIGVSKSKILLVFFYPL 827

  Fly  1009 NSCCNPFLYAIMTKQFKKDCVTLCKHF 1035
            |||.||:||||:|.|::||..:|..::
Mosquito   828 NSCANPYLYAILTVQYRKDLFSLLANY 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	5/23 (22%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	241/742 (32%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	52/213 (24%)
		leucine-rich repeat	349..371	CDD:275380	3/11 (27%)
		LRR_8	370..425	CDD:290566	13/55 (24%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	418..486	CDD:275380	15/68 (22%)
		leucine-rich repeat	441..464	CDD:275378	2/23 (9%)
		LRR_8	487..545	CDD:290566	16/58 (28%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	16/56 (29%)
		leucine-rich repeat	535..558	CDD:275380	7/23 (30%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433	65/127 (51%)
		7tm_1	770..1017	CDD:278431	117/251 (47%)
GPRFSH	XP_309589.2	leucine-rich repeat	154..181	CDD:275380	5/26 (19%)
		leucine-rich repeat	204..229	CDD:275380	8/46 (17%)
		leucine-rich repeat	246..274	CDD:275380	8/27 (30%)
		leucine-rich repeat	275..299	CDD:275380	8/25 (32%)
		LRR_8	279..335	CDD:290566	15/56 (27%)
		leucine-rich repeat	300..324	CDD:275380	7/23 (30%)
		leucine-rich repeat	325..345	CDD:275380	7/19 (37%)
		leucine-rich repeat	346..368	CDD:275380	5/21 (24%)
		7tm_1	585..836	CDD:278431	117/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810