DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP011229

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_309414.4	Gene:	AgaP_AGAP011229 / 1270695	VectorBaseID:	AGAP011229	Length:	398	Species:	Anopheles gambiae

Alignment Length:	381	Identity:	113/381 - (29%)
Similarity:	166/381 - (43%)	Gaps:	63/381 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEV-----------------------VVLDLGNNNLTK 193
            |.|.|...| |..|.|.|:..||:.|..:|                       .||||..|.:..
Mosquito    34 CTCEGDPNV-RTWCIGAGLDVVPIQLNPDVRYINLTANRITNVHFTLTFYYKLEVLDLAGNRIEA 97

  Fly   194 LEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCG--LKSLPPQSFQGLAQLTSL 256
            |.:.:|.....|..|.||||:|:::..:||.||.:|:.|.|  ||  :.::.|.:|..|..|..|
Mosquito    98 LGSRNFDTQQALRTLNLSDNAIVSIPKDAFRGLQRLQTLKL--CGNRIDTIHPAAFHDLRNLIEL 160

  Fly   257 QLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIP-TNALAGL-RTLEALNLGSNLLTIINDEDF 319
            .|.||||.||:...|.||..|..|..:.|....:| ...|..| :.|:.|:|..|||..|.::.|
Mosquito   161 DLEGNALTSLEPSTLRHLYSLEVLSFQNNQLLEVPYERNLEHLGQRLQLLDLSVNLLEYIANDSF 225

  Fly   320 PRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPE-GLSKLSQLQELSITSNRLR 383
            ..:..|..|.|..|.:.::..||...|:.||.|::.||.::.:|. .||||..|..||::.|...
Mosquito   226 VALRELRTLRLGGNILTELDYGAFHGLSGLKALDIVDNNLTVVPTLQLSKLCNLTYLSLSGNYFE 290

  Fly   384 WINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTL-----RSFPELEACHALEI 443
                 .||..                 ||..:.:|::|.|..:..|     |:|.:..   ||.|
Mosquito   291 -----SLPAV-----------------AFLNLFQLQQLHLDRLDRLQRIDARAFVDNA---ALRI 330

  Fly   444 LKL-DRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRD-LRLLDLSSNQI 497
            |.| |......:|..|....|.|..:.::.|:|.|:..:....| |..|:|..|.:
Mosquito   331 LTLDDNPSFASLPLRLFHSNPNLAEISMRRNALIRLDAVHFPLDRLHRLELGGNPL 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	74/230 (32%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	24/61 (39%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	8/24 (33%)
		LRR_8	252..311	CDD:290566	22/60 (37%)
		leucine-rich repeat	253..276	CDD:275380	12/22 (55%)
		leucine-rich repeat	277..300	CDD:275380	6/24 (25%)
		LRR_8	299..359	CDD:290566	20/59 (34%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	48/179 (27%)
		leucine-rich repeat	349..371	CDD:275380	10/22 (45%)
		LRR_8	370..425	CDD:290566	11/54 (20%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	19/73 (26%)
		leucine-rich repeat	441..464	CDD:275378	7/23 (30%)
		LRR_8	487..545	CDD:290566	4/11 (36%)
		leucine-rich repeat	487..510	CDD:275380	4/11 (36%)
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP011229	XP_309414.4	leucine-rich repeat	62..84	CDD:275380	1/21 (5%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR_RI	<108..289	CDD:238064	66/182 (36%)
		LRR_8	109..167	CDD:290566	24/59 (41%)
		leucine-rich repeat	109..132	CDD:275380	11/22 (50%)
		leucine-rich repeat	133..156	CDD:275380	8/24 (33%)
		LRR_8	155..239	CDD:290566	29/83 (35%)
		leucine-rich repeat	157..180	CDD:275380	12/22 (55%)
		leucine-rich repeat	181..206	CDD:275380	6/24 (25%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR_8	229..289	CDD:290566	21/59 (36%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		LRR_8	278..337	CDD:290566	20/83 (24%)
		leucine-rich repeat	279..302	CDD:275380	8/44 (18%)
		leucine-rich repeat	303..324	CDD:275380	6/20 (30%)
		leucine-rich repeat	353..366	CDD:275378	3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910