DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and GPRGNR1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001687839.2	Gene:	GPRGNR1 / 1269400	VectorBaseID:	AGAP002156	Length:	354	Species:	Anopheles gambiae

Alignment Length:	309	Identity:	67/309 - (21%)
Similarity:	131/309 - (42%)	Gaps:	56/309 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 VFLLSLLGNGTVVFVL----LCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMF 823
            :.:.|..||.||:.:|    :.:.|::::   ::.:||.||..:...:..|.|..|        :
Mosquito    57 LMVFSATGNLTVLSILAQRKVRASSRINI---MLAHLAIADLLVTFLMMPLEIGWA--------Y 110

  Fly   824 AIPWQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITH--AIHLNKRLSLKQAGYIMS--V 883
            .:.|.. .::|::..|.......||.:.|..|:::|.:|:..  .:|.::.:.:..|.:|||  .
Mosquito   111 TVRWTAGDLMCRVMAFFRTFGLYLSSFILICISVDRYFAVLKPLKVHEHRAVLMIAAAWIMSGLC 175

  Fly   884 GWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTY---VISLMFINGCAFLTLMGCYLKMY 945
            ....|.|..|.....::.|::......||...  ..:.|   |:.||:.  ...:.::.||..:|
Mosquito   176 SLPQAFIFHLEGHPNITGYQQCVTYHYFEEEI--YQIIYNVLVMCLMYT--FPLIVILYCYGSIY 236

  Fly   946 WAI------RGSQAWNTNDSRI---AKR-------MALLVFTDFLCWSPIAFFSITAIFGLQLIS 994
            :.|      |..:::..:...:   |||       |.::||.  :||:|  ::.::..:.|...|
Mosquito   237 YEIFSRTNPRNLESFRRSSIDVLGRAKRKTLRMTIMIVIVFV--VCWTP--YYVMSLWYWLDKES 297

  Fly   995 LE------QAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEE 1037
            .:      |..:|  .....|||.||.:|.:...: ||....|.|...|
Mosquito   298 AKNVDQRIQKGLF--LFASTNSCMNPVVYGVFNVR-KKHTKKLLKTTHE 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	30/136 (22%)
		7tm_1	770..1017	CDD:278431	60/280 (21%)
GPRGNR1	XP_001687839.2	7tm_1	64..324	CDD:278431	60/280 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910