DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and GPRALS3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_307800.2	Gene:	GPRALS3 / 1269203	VectorBaseID:	AGAP010486	Length:	453	Species:	Anopheles gambiae

Alignment Length:	388	Identity:	95/388 - (24%)
Similarity:	153/388 - (39%)	Gaps:	100/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 ATSY--MEEY--FEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLP--MPGPFLPCADLFDW 753
            |||:  :.||  ..:.:||      ..|..|.:....:.|. |:..|.|  ||..:.....|:.
Mosquito     6 ATSFFLLGEYDSLTDQNVS------QLGNYLENSDPNQTFM-GNFTCPPTDMPTTYYLFMFLYA- 62

  Fly   754 WTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAAD--FFMGIYLGILAIVDAAT 816
                    ||.|:.:|||..|::|:|...:...|....:.|||.||  |.:||...|      ||
Mosquito    63 --------VVCLVGVLGNTLVIYVVLRFSNMQTVTNMYILNLAIADECFLIGIPFLI------AT 113

  Fly   817 LGEFRMFAIPWQM-SVLCQLSGFLAVLSSELSVYT----LAVITLERNYAITHAIHLNKRLSLKQ 876
            :...|     |.: ..:|:    ..::|:.::.:|    |.:::.:|..||.|.|...|..:...
Mosquito   114 MHMKR-----WTLGGAMCK----AYMVSTSVTQFTSSIFLFIMSADRYIAICHHISSPKYRTPLV 169

  Fly   877 AGYIMSVGWV-FALIMALMPLVGVSDY-----RKFAVCLPFETTTG----------PASLTYVIS 925
            :..:..:.|: .||||  :|::..:|.     ..::..:.:..|.|          ...|.:||.
Mosquito   170 SRIVSLLAWLASALIM--LPIMIYADVIEQKPNTYSCQILWPETHGHLPGYTFTLYSLILGFVIP 232

  Fly   926 LMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKR-------MALLVFTDF-LCWSPIAFF 982
            |.||        |..|..:...:|......|..||..:|       :.|.|.|.: |||.|....
Mosquito   233 LCFI--------MTFYCLVIRKLRNVGPKTTGKSRGKRRSHRKVTKLVLTVITVYILCWLPYWIS 289

  Fly   983 SITAIFG--------LQLISLEQAKIFTVFVLP-----LNSCCNPFLYAIMTKQFKKDCVTLC 1032
            .:..|..        |.||         :|:|.     :||..||.|||.:::.|||..:..|
Mosquito   290 QVALITSDFETCSTRLDLI---------LFLLVGCLGYINSAINPILYAYLSENFKKSFLKAC 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	35/135 (26%)
		7tm_1	770..1017	CDD:278431	68/290 (23%)
GPRALS3	XP_307800.2	7tm_4	63..>276	CDD:304433	56/237 (24%)
GPRALS3	XP_307800.2	7tm_1	71..328	CDD:278431	68/290 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910