DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrrc7

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001380603.1	Gene:	Lrrc7 / 117284	RGDID:	708527	Length:	1542	Species:	Rattus norvegicus

Alignment Length:	688	Identity:	161/688 - (23%)
Similarity:	248/688 - (36%)	Gaps:	215/688 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 EAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVL---RLSCRGI 168
            |.:|:   |:.:|  |..|......:|...:|||.   |.:|.     ...:|.|   ..:|:.:
  Rat    25 EEEII---SVLDY--SHCSLQQVPKEVFNFERTLE---ELYLD-----ANQIEELPKQLFNCQAL 76

  Fly   169 GILAVPVN----LPNEVV------VLDLGNNN-------------LTKLEA---------NSFFM 201
            ..|::|.|    ||..:.      .||:..|.             ||.:||         :.|..
  Rat    77 RKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQ 141

  Fly   202 APNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSL 266
            ..||.:|.|:| :.:...|..|..|.||:.|.|:...||:| |:|...||||..|.|..|....|
  Rat   142 LLNLTQLYLND-AFLEFLPANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEFSEL 204

  Fly   267 DGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLK 331
            . :.|..:|.||.|.::.|....:| .::..|:.|..|::..|.:..: |.|......|..|||.
  Rat   205 P-EVLDQIQNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETV-DMDISGCEALEDLLLS 266

  Fly   332 RNQIMKI--SAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSM 394
            .|.:.::  |.|.||.||.|||   |||.::.||..:..||.|:|...:.|.|.     .||
  Rat   267 SNMLQQLPDSIGLLKKLTTLKV---DDNQLTMLPNTIGNLSLLEEFDCSCNELE-----SLP--- 320

  Fly   395 QMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANL- 458
                                                  |.:...|:|..|.:|...:.|:|..:
  Rat   321 --------------------------------------PTIGYLHSLRTLAVDENFLPELPREIG 347

  Fly   459 -CRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFN--GLKQLNDLLLSYN 519
             |:   .:..:.|::|.|:.:| .:...:.||:|:||.|:::.:   ||:  .||:|..|.||.|
  Rat   348 SCK---NVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNL---PFSFTKLKELAALWLSDN 406

  Fly   520 RIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLK 584
            :.|||       ||    |..|.      |.|.       :...|.|.:||:.|...........
  Rat   407 QSKAL-------IP----LQTEA------HPET-------KQRVLTNYMFPQQPRGDEDFQSDSD 447

  Fly   585 TFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTL- 648
            :| ||.|.|                                :::..::..|..|....|.|.:.
  Rat   448 SF-NPTLWE--------------------------------EQRQQRMTVAFEFEDKKEDDESAG 479

  Fly   649 ----------WNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYF 703
                      |:.....|..|...||    .....||...    ::|:|
  Rat   480 KVKALSCQAPWDRGQRGITLQPARLS----GDCCTPWARC----DQQIQ---------------- 520

  Fly   704 EEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMP 741
               |:..|.:......|..||:..|     ...|.|:|
  Rat   521 ---DMPVPQSDPQLAWGCISGLQQE-----RSMCAPLP 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/27 (26%)
		LRR_RI	180..>383	CDD:238064	70/232 (30%)
		leucine-rich repeat	183..204	CDD:275380	8/42 (19%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	22/61 (36%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	10/24 (42%)
		LRR_RI	327..567	CDD:238064	63/246 (26%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	7/54 (13%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	12/70 (17%)
		leucine-rich repeat	441..464	CDD:275378	6/24 (25%)
		LRR_8	487..545	CDD:290566	22/59 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/24 (38%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	11/55 (20%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc7	NP_001380603.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910