DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Rtn4r

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_446065.1	Gene:	Rtn4r / 113912	RGDID:	620810	Length:	473	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	95/375 - (25%)
Similarity:	143/375 - (38%)	Gaps:	102/375 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QITVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTL 140
            ::|.:|..:.....|.||          |....:|.       .||:::|....|
  Rat    38 KVTTSRPQQGLQAVPAGI----------PASSQRIF-------LHGNRISYVPAA---------- 75

  Fly   141 HSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNL 205
                            |.:    |||.:             .:|.|.:|.|..::|.:|.....|
  Rat    76 ----------------SFQ----SCRNL-------------TILWLHSNALAGIDAAAFTGLTLL 107

  Fly   206 EELTLSDNSIIN-MDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGD 269
            |:|.||||:.:. :||..|.||..|..|.|..|||:.|.|..|:|||.|..|.|..|.|.:|..:
  Rat   108 EQLDLSDNAQLRVVDPTTFRGLGHLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNNLQALPDN 172

  Fly   270 CLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQ 334
            ....|..|..|.|.||....:|.:|..||.:|:.|.|..|.:..::...|..:..|:.|.|..|.
  Rat   173 TFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANN 237

  Fly   335 IMKISAGALKNLTALKVLELDDN------------------------LISSLPEGLS-------K 368
            :..:.|..|..|.:|:.|.|:||                        :.|:||:.|:       .
  Rat   238 LSMLPAEVLVPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSGVPSNLPQRLAGRDLKRLA 302

  Fly   369 LSQLQELSITSNRLR-----WINDTE---LPRSMQMLDMRANPLSTISPG 410
            .|.|:..::.|...|     .:.|.|   ||:..|  ...|:..|.:.||
  Rat   303 TSDLEGCAVASGPFRPFQTNQLTDEELLGLPKCCQ--PDAADKASVLEPG 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	70/234 (30%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	28/60 (47%)
		leucine-rich repeat	205..228	CDD:275380	12/23 (52%)
		leucine-rich repeat	229..252	CDD:275380	11/22 (50%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	17/83 (20%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	28/123 (23%)
		leucine-rich repeat	349..371	CDD:275380	9/52 (17%)
		LRR_8	370..425	CDD:290566	13/49 (27%)
		leucine-rich repeat	372..393	CDD:275380	7/28 (25%)
		leucine-rich repeat	394..415	CDD:275380	5/17 (29%)
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Rtn4r	NP_446065.1	LRR 1. /evidence=ECO:0000255	56..79		7/59 (12%)
		LRR_8	60..115	CDD:290566	20/104 (19%)
		leucine-rich repeat	60..82	CDD:275380	8/58 (14%)
		LRR 2. /evidence=ECO:0000255	80..103		8/35 (23%)
		LRR_RI	81..>261	CDD:238064	63/192 (33%)
		leucine-rich repeat	83..106	CDD:275380	6/35 (17%)
		LRR 3. /evidence=ECO:0000255	105..128		10/22 (45%)
		leucine-rich repeat	107..131	CDD:275380	12/23 (52%)
		LRR 4. /evidence=ECO:0000255	129..152		10/22 (45%)
		LRR_8	131..190	CDD:290566	24/58 (41%)
		leucine-rich repeat	132..155	CDD:275380	11/22 (50%)
		LRR 5. /evidence=ECO:0000255	153..176		8/22 (36%)
		LRR_4	156..195	CDD:289563	12/38 (32%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		LRR 6. /evidence=ECO:0000255	178..200		7/21 (33%)
		LRR_8	179..238	CDD:290566	18/58 (31%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		LRR 7. /evidence=ECO:0000255	202..224		5/21 (24%)
		leucine-rich repeat	204..227	CDD:275380	5/22 (23%)
		LRR 8. /evidence=ECO:0000255	225..248		6/22 (27%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		LRR 9. /evidence=ECO:0000255	250..273		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..446		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910