DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP013059

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_003436644.1	Gene:	AgaP_AGAP013059 / 11175769	VectorBaseID:	AGAP013059	Length:	517	Species:	Anopheles gambiae

Alignment Length:	351	Identity:	95/351 - (27%)
Similarity:	153/351 - (43%)	Gaps:	46/351 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 LTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYR-IPTNALAGLRTLEALNLGSNLLTIIND 316
            :|.|.::...::.:.......|..|.:..:..:|||| |..|:......|..:.:....:|:::.
Mosquito    62 ITKLTISNKKIIGVPTKMFASLPNLESFIVLNSLFYREIDPNSFVDCNKLNHIEITGTNITLLDS 126

  Fly   317 EDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGL-SKLSQLQELSITSN 380
            ..||:.|.|..||...|:|.:|...|.:.|..|:.|.|..|.::.||.|: .||.:|:.|.:..|
Mosquito   127 HMFPKTPKLQYLLFHHNRIAEIKHDAFEFLGELEELNLSYNNLTRLPSGVFHKLRKLKTLDLNHN 191

  Fly   381 RLRWIN-DTELPR----SMQMLDMRANPLSTISPGAFRGMSKLRKL-----ILSDVRTLRSFPEL 435
            ||..:: |:..|.    ::..||...|.|..:|   :..:| :||:     .|:.|....:..|.
Mosquito   192 RLLLLSFDSWFPPDGAVALTYLDASYNQLVDMS---WTEIS-VRKVNLKYNNLTSVHVNGNCSEF 252

  Fly   436 EACH-ALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRD-LRLLDLSSNQIE 498
            .|.| |::::.:.|.         |    .|:.|.|..|.|:....|..|.| ||.||:|.|..:
Mosquito   253 HASHNAIDMVTVGRN---------C----SLEKLYLAHNRLQGFDWLQRCADTLRSLDISHNLQQ 304

  Fly   499 KIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLN 563
            |  |..|..|||:..|.:....| :|.......:.||:.||:..|.:..|..|..:....||.|.
Mosquito   305 K--GTDFLNLKQITALNIECTNI-SLNYKTLHDLRKLRFLDISYNNLKKIDLENLTSQRLLERLM 366

  Fly   564 L-GNNI-----------FPELPESGL 577
            : ||.|           ||.|...|:
Mosquito   367 ISGNPIANISIGSIKRNFPNLKSLGI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	36/131 (27%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	2/9 (22%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	11/58 (19%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	7/23 (30%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	73/253 (29%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	16/64 (25%)
		leucine-rich repeat	372..393	CDD:275380	7/25 (28%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	17/73 (23%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	17/57 (30%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	10/31 (32%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP013059	XP_003436644.1	leucine-rich repeat	62..85	CDD:275380	3/22 (14%)
		LRR_8	84..145	CDD:290566	16/60 (27%)
		leucine-rich repeat	86..110	CDD:275380	7/23 (30%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		LRR_8	133..193	CDD:290566	21/59 (36%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR_RI	158..398	CDD:238064	72/255 (28%)
		leucine-rich repeat	159..182	CDD:275380	9/22 (41%)
		leucine-rich repeat	183..209	CDD:275380	7/25 (28%)
		leucine-rich repeat	230..269	CDD:275380	10/51 (20%)
		LRR_8	269..348	CDD:290566	28/81 (35%)
		leucine-rich repeat	270..288	CDD:275380	6/17 (35%)
		leucine-rich repeat	293..337	CDD:275380	15/46 (33%)
		LRR	<309..>401	CDD:227223	24/85 (28%)
		leucine-rich repeat	338..358	CDD:275380	6/19 (32%)
		leucine-rich repeat	362..382	CDD:275380	6/19 (32%)
		leucine-rich repeat	387..399	CDD:275378	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910