DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and NPFFR2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001138228.1	Gene:	NPFFR2 / 10886	HGNCID:	4525	Length:	423	Species:	Homo sapiens

Alignment Length:	305	Identity:	61/305 - (20%)
Similarity:	129/305 - (42%)	Gaps:	54/305 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 WVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAI 825
            :::|.|.::||..|.|:::.::....|....:.|||.:|..:||:...:.::|....|
Human    56 FLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAG------- 113

  Fly   826 PWQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFAL 889
             |.. :.:|::||.:..:|...||:||..|.::|...:.:.  ...:|::|.|..|:.:.||.|
Human   114 -WPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYP--FKPKLTIKTAFVIIMIIWVLA- 174

  Fly   890 IMALMP---LVGVSDYRKFAVCLPFETTTGPA-----------SLTYVISLMFINGCAFLTLMGC 940
            |..:.|   ::.|.:.:.:.|.|..:..|.|.           ......:::|.|  .:|..:..
Human   175 ITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFAN--IYLAPLSL 237

  Fly   941 YLKMYWAI--------------RGSQAWNT---NDSRIAKRMALLVFTDFLCWSPIAFFSITAIF 988
            .:.||..|              :..:.|:.   ...:|.|.:.::.....|.|.|:  :::..:.
Human   238 IVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPL--WTLMMLS 300

  Fly   989 GLQLISLEQAKIFTVFVLPL-------NSCCNPFLYAIMTKQFKK 1026
            ....:|..:.:|..:::.|.       ||..||.:|....:.|::
Human   301 DYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRR 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	34/128 (27%)
		7tm_1	770..1017	CDD:278431	57/285 (20%)
NPFFR2	NP_001138228.1	7tm_4	56..>178	CDD:304433	34/132 (26%)
NPFFR2	NP_001138228.1	7tm_1	65..336	CDD:278431	57/285 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910