DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Lgr4

DIOPT Version :10

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_766259.2 Gene:Lgr4 / 107515 MGIID:1891468 Length:951 Species:Mus musculus


Alignment Length:881 Identity:266/881 - (30%)
Similarity:407/881 - (46%) Gaps:107/881 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.|.   .|:.|.|.|:.|||..|......||:..||:|:|..::|...|.||||.|:.|.:.
Mouse    33 CSCDGD---RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLS 94

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:.|.|..||.:||.|:|||..||::|.::.:||:.|.||:|:.|.:.|:..|....|.:||.|.
Mouse    95 FIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLW 159

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|:...:|...|:.|.||:||.|..|.::.|.|..|..:.:|:||.|..|:|..:|......|
Mouse   160 LDDNILTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGL 224

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND-----TELPRSMQMLDMRANPLST 406
            ..|:.|:|:.|.:...|:.:..|..|:||...||.:..|.|     ..|.|::.:.|   ||||.
Mouse   225 DNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFAGNPLLRTIHLYD---NPLSF 286

  Fly   407 ISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471
            :...||..:|.|..|::.....::.||.|.....||.|.|....|..:|.:||:....|::|:|.
Mouse   287 VGNSAFHNLSDLHSLVIRGASLVQWFPNLAGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLS 351

  Fly   472 TNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536
            .|.::.:|:                        |||.:.|.::.|..|:|..:.:..|||:..|:
Mouse   352 YNDIRDLPS------------------------FNGCRALEEISLQRNQISLIKETTFQGLTSLR 392

  Fly   537 LLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFP 601
            :|||..|.|..||..||:....:.:|::..|.....|..||..|..||...|.:|::......|.
Mouse   393 ILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFQLKDALAARDFA 457

  Fly   602 RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQ 666
            .:::|.:.|||.||||                    :..|:..::...:||     ||.|:::|:
Mouse   458 NLRSLSVPYAYQCCAF--------------------WGCDSYANLNTEDNS-----PQDHSVTKE 497

  Fly   667 LGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ 731
            .||                    |....|||..|.  |||...                      
Mouse   498 KGA--------------------TDAANATSTAES--EEHSQI---------------------- 518

  Fly   732 PGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLA 796
              .:.|.|..|.|.||..|...|.:|..||.:||::||.|..|:..:..|.|.:...:..:..::
Mouse   519 --IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLIS 581

  Fly   797 AADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYA 861
            .::..||||.|||..:||.:.|.|..|.|.|:....|:::|.|||.|||.:|:.|.:..:||:..
Mouse   582 VSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVF 646

  Fly   862 ITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISL 926
            ....:...|...|:|......|..:.|.|....||.....|....:||||.|...| ||.:.::|
Mouse   647 AKDVMKNGKSSHLRQFQVAALVALLGAAIAGCFPLFHGGQYSASPLCLPFPTGETP-SLGFTVTL 710

  Fly   927 MFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQ 991
            :.:|..|||.:...|.|:|..:........:.|.:.|.:|.|:||:.:.:.|:||||...:....
Mouse   711 VLLNSLAFLLMAIIYTKLYCNLEKEDPSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 775

  Fly   992 LISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKD 1027
            .||.|..|..|:...||.:|.||.||.....:||.|
Mouse   776 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKDD 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 LRR <157..390 CDD:443914 83/237 (35%)
leucine-rich repeat 158..179 CDD:275380 8/20 (40%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 11/22 (50%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR 292..612 CDD:443914 93/324 (29%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..348 CDD:275380 8/22 (36%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..393 CDD:275380 8/25 (32%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 18/67 (27%)
leucine-rich repeat 441..464 CDD:275378 8/22 (36%)
leucine-rich repeat 487..510 CDD:275380 3/22 (14%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 89/274 (32%)
TM helix 1 755..781 CDD:320264 9/25 (36%)
TM helix 2 788..813 CDD:320264 7/24 (29%)
TM helix 3 833..863 CDD:320264 12/29 (41%)
TM helix 4 875..897 CDD:320264 5/21 (24%)
TM helix 5 918..947 CDD:320264 10/28 (36%)
TM helix 6 956..986 CDD:320264 11/29 (38%)
TM helix 7 996..1021 CDD:320264 10/24 (42%)
Lgr4NP_766259.2 LRRNT 29..61 CDD:214470 11/30 (37%)
LRR 1 58..79 7/20 (35%)
leucine-rich repeat 59..82 CDD:275380 7/22 (32%)
LRR <75..384 CDD:443914 104/335 (31%)
LRR 2 82..103 8/20 (40%)
leucine-rich repeat 83..106 CDD:275380 10/22 (45%)
LRR 3 106..127 9/20 (45%)
leucine-rich repeat 107..130 CDD:275380 11/22 (50%)
LRR 4 130..151 7/20 (35%)
leucine-rich repeat 131..154 CDD:275380 8/22 (36%)
LRR 5 154..177 7/22 (32%)
leucine-rich repeat 155..178 CDD:275380 8/22 (36%)
LRR 6 178..199 9/20 (45%)
leucine-rich repeat 179..202 CDD:275380 8/22 (36%)
LRR 7 202..223 7/20 (35%)
leucine-rich repeat 203..226 CDD:275380 8/22 (36%)
LRR 8 226..247 5/20 (25%)
leucine-rich repeat 227..249 CDD:275380 6/21 (29%)
LRR 9 249..270 7/20 (35%)
leucine-rich repeat 250..273 CDD:275380 7/22 (32%)
LRR 10 273..294 9/23 (39%)
leucine-rich repeat 274..295 CDD:275380 8/23 (35%)
LRR 11 320..341 8/20 (40%)
leucine-rich repeat 321..344 CDD:275380 8/22 (36%)
LRR 12 344..365 8/44 (18%)
leucine-rich repeat 345..366 CDD:275380 8/44 (18%)
LRR_8 365..425 CDD:404697 19/59 (32%)
LRR 13 366..387 5/20 (25%)
leucine-rich repeat 367..390 CDD:275380 7/22 (32%)
LRR 14 390..411 10/20 (50%)
leucine-rich repeat 391..414 CDD:275380 10/22 (45%)
LRR 15 414..435 5/20 (25%)
leucine-rich repeat 415..438 CDD:275380 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..512 12/49 (24%)
7tmA_LGR4 539..812 CDD:320483 89/274 (32%)
TM helix 1 540..566 CDD:320483 9/25 (36%)
TM helix 2 573..598 CDD:320483 7/24 (29%)
TM helix 3 618..648 CDD:320483 12/29 (41%)
TM helix 4 660..682 CDD:320483 5/21 (24%)
TM helix 5 702..731 CDD:320483 11/29 (38%)
TM helix 6 740..770 CDD:320483 11/29 (38%)
TM helix 7 780..805 CDD:320483 10/24 (42%)

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