DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and TLR6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001381482.1	Gene:	TLR6 / 10333	HGNCID:	16711	Length:	796	Species:	Homo sapiens

Alignment Length:	944	Identity:	167/944 - (17%)
Similarity:	311/944 - (32%)	Gaps:	320/944 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 GILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAF---------- 223
            |::.||.:||.:..|||:..|.:.:|:.:.......|..|.||.|.|..:|.:.|
Human    42 GLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLD 106

  Fly   224 -----------YGLAKLKRLSLQNCGLKSLP-PQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK 276
                       :.:...:.|.|.....|:|| .:.|..|:||..|.|:...|..||...:.||.
Human   107 LSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLH- 170

  Fly   277 LRTLRLEGNLFYRIPTNALAGLRTLEA----------------LNLGSNLLTI-------INDED 318
            |..:.|:...:| |..|....|:.|.|                :|:..|.|..       :||::
Human   171 LSYILLDLRNYY-IKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDN 234

  Fly   319 FPRMPNLIVLLLKRNQIMKISAGALK------------------------NLTALKVLELDDNLI 359
            .......:..|.:.:.::..:...::                        |||.::.:..:|...
Human   235 CQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTY 299

  Fly   360 SSLPEGLSKLSQLQELSI--TSNRLRWINDTEL-----PRSMQMLDMRANP----LSTISPGAFR 413
            |.        :.|:.|:|  .:|::...:.|.|     ..::.||.:...|    |...:|..|:
Human   300 SK--------TTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFK 356

  Fly   414 GMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV--PANLCRQTPRLKSLELKTNSLK 476
            .::..:.:....:     |.:......||.|.|.:.|::::  ...:.:..|.|:.|::..|||:
Human   357 FLNFTQNVFTDSI-----FEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLE 416

  Fly   477 RIPNLSSC---RDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLL 538
            ...:..:|   ..:.:|:||||                   :|:.:..:.||       |::::|
Human   417 SGRHKENCTWVESIVVLNLSSN-------------------MLTDSVFRCLP-------PRIKVL 455

  Fly   539 DLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRI 603
            ||..|:|..:.|:... ..||::||:..|...:||..|..:.|.:...::..: ..|..|.|...
Human   456 DLHSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSV-SHPSADFFQSC 518

  Fly   604 QTLILSYA----YHC-CAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNL 663
            |.:....|    :.| |.....|     |...||...||                 ..||.
Human   519 QKMRSIKAGDNPFQCTCELREFV-----KNIDQVSSEVL-----------------EGWPD---- 557

  Fly   664 SKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTE 728
                                             ||..:|.|.                :.|...:
Human   558 ---------------------------------SYKCDYPES----------------YRGSPLK 573

  Fly   729 DFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVC 793
            ||....:.|                                 |.|::.|.
Human   574 DFHMSELSC---------------------------------NITLLIVT--------------- 590

  Fly   794 NLAAADFFMGIYLGILAIVDAATLGEFRMFA-IPWQMSVLCQLSGFLAVLSSELSVYTLAVITLE 857
                        :|...:|.|.|:....::. :||.:.::||.:      .:......:.:..|:
Human   591 ------------IGATMLVLAVTVTSLCIYLDLPWYLRMVCQWT------QTRRRARNIPLEELQ 637

  Fly   858 RNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFET-TTGPASLT 921
            ||......|..::..|          .||.:   .|:|.:...|.:   :||.... ..|.:.:.
Human   638 RNLQFHAFISYSEHDS----------AWVKS---ELVPYLEKEDIQ---ICLHERNFVPGKSIVE 686

  Fly   922 YVISL-------MFINGCAFLTLMGCYLKMYWA-----IRGSQ----------AWNTNDSRIAKR 964
            .:|:.       :|:....|:....|:.::|:|     ..||.          ..|:..::..|.
Human   687 NIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKL 751

  Fly   965 MALLVFTDFLCWSP------IAFFSITAIFGLQL 992
            .||:....:|.|..      :.:.:|.|.|.::|
Human   752 KALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKL 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/9 (44%)
		LRR_RI	180..>383	CDD:238064	52/273 (19%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	19/81 (23%)
		leucine-rich repeat	205..228	CDD:275380	8/43 (19%)
		leucine-rich repeat	229..252	CDD:275380	7/23 (30%)
		LRR_8	252..311	CDD:290566	19/74 (26%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	12/106 (11%)
		leucine-rich repeat	301..324	CDD:275380	7/45 (16%)
		leucine-rich repeat	325..348	CDD:275380	3/46 (7%)
		LRR_RI	327..567	CDD:238064	50/279 (18%)
		leucine-rich repeat	349..371	CDD:275380	2/21 (10%)
		LRR_8	370..425	CDD:290566	12/65 (18%)
		leucine-rich repeat	372..393	CDD:275380	6/27 (22%)
		leucine-rich repeat	394..415	CDD:275380	6/24 (25%)
		leucine-rich repeat	418..486	CDD:275380	13/72 (18%)
		leucine-rich repeat	441..464	CDD:275378	5/24 (21%)
		LRR_8	487..545	CDD:290566	13/57 (23%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	16/55 (29%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433	18/128 (14%)
		7tm_1	770..1017	CDD:278431	42/253 (17%)
TLR6	NP_001381482.1	LRR 1	54..77		5/22 (23%)
		LRR 2	78..101		8/22 (36%)
		LRR 3	102..122		0/19 (0%)
		LRR 4	123..147		7/23 (30%)
		LRR 5	148..168		6/19 (32%)
		LRR 6	169..196		8/28 (29%)
		LRR 7	197..219		1/21 (5%)
		LRR 8	220..250		4/29 (14%)
		LRR 9	251..277		0/25 (0%)
		LRR 10	278..303		5/32 (16%)
		LRR 11	304..330		6/25 (24%)
		LRR 12	331..354		5/22 (23%)
		LRR 13	355..378		2/27 (7%)
		LRR 14	379..404		5/24 (21%)
		LRR 15	405..429		6/23 (26%)
		LRR 16	430..450		8/45 (18%)
		LRR 17	451..474		6/23 (26%)
		LRR 18	475..496		7/20 (35%)
		LRR 19	497..520		4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910