DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and LRRC17

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001026862.1	Gene:	LRRC17 / 10234	HGNCID:	16895	Length:	441	Species:	Homo sapiens

Alignment Length:	328	Identity:	83/328 - (25%)
Similarity:	127/328 - (38%)	Gaps:	82/328 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISA 340
            |:|||:  .|:|.:        .:.|::|:|..|.::.|..|.|..:..|..|||:.|||..::.
Human    92 KIRTLK--NNMFSK--------FKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTE 146

  Fly   341 GALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLS 405
            ........|..|.|.||......|..:.:|.||                :||:..:    .|...
Human   147 EVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ----------------IPRNRNL----GNYAK 191

  Fly   406 TISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLD-------RAGI--QEVPANLCRQ 461
            ..||...:.            :.||.....:.|:..|..:||       |..:  .||.:..|..
Human   192 CESPQEQKN------------KKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHN 244

  Fly   462 --TPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKAL 524
              .| :::|:.|...||::|| :...|:..||                        ||||:|..|
Human   245 YVFP-IQTLDCKRKELKKVPN-NIPPDIVKLD------------------------LSYNKINQL 283

  Fly   525 PQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTF--- 586
            ....|:.:.:|:.|:|..|.|.:|...||.|.|.||:|:|.||.........|..|..||..
Human   284 RPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLR 348

  Fly   587 NNP 589
            :||
Human   349 DNP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	29/106 (27%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	10/34 (29%)
		leucine-rich repeat	253..276	CDD:275380	83/328 (25%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	61/250 (24%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	17/78 (22%)
		leucine-rich repeat	441..464	CDD:275378	7/33 (21%)
		LRR_8	487..545	CDD:290566	13/57 (23%)
		leucine-rich repeat	487..510	CDD:275380	2/22 (9%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	20/58 (34%)
		leucine-rich repeat	535..558	CDD:275380	9/22 (41%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LRRC17	NP_001026862.1	leucine-rich repeat	63..81	CDD:275380
		LRR 1	82..103		6/12 (50%)
		LRR_8	84..141	CDD:290566	18/58 (31%)
		leucine-rich repeat	84..106	CDD:275380	6/23 (26%)
		LRR_4	105..146	CDD:289563	14/40 (35%)
		LRR 2	106..127		7/20 (35%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 3	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..244	CDD:275380	24/120 (20%)
		leucine-rich repeat	249..269	CDD:275380	6/20 (30%)
		LRR_RI	<267..>351	CDD:238064	30/107 (28%)
		LRR 4	269..290		10/44 (23%)
		leucine-rich repeat	270..293	CDD:275380	9/46 (20%)
		LRR_8	272..328	CDD:290566	25/79 (32%)
		LRR 5	293..314		8/20 (40%)
		LRR_4	294..332	CDD:289563	16/37 (43%)
		leucine-rich repeat	294..317	CDD:275380	9/22 (41%)
		LRR 6	317..340		7/22 (32%)
		leucine-rich repeat	318..341	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910