DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and chad

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017953398.1	Gene:	chad / 101732210	XenbaseID:	XB-GENE-957654	Length:	360	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	79/327 - (24%)
Similarity:	136/327 - (41%)	Gaps:	55/327 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 HCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSI 215
            :|||.|. ::..:.|...|:..:| .:..:..:|:|..||...|.
Frog    26 NCHCHGG-DLQHVICDTAGLTKLP-KVSEQTRLLNLQRNNFPVLA-------------------- 68

  Fly   216 INMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTL 280
                ||||..:..|..|.:|:|.::.:...:|:||.:|..|.|:.|.:..|.......|.:|..|
Frog    69 ----PNAFKEMKGLVSLHMQHCKIREVSSGAFRGLKRLVYLYLSNNEISVLGTGAFDELSELTYL 129

  Fly   281 RLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKN 345
            .::.|....:|....:.|..|..|.||:|.:..:....|....:|..|.|..|:|..:..|:|..
Frog   130 YMDHNKIIDLPKGLFSPLFNLFILQLGNNKVRDLKAATFTGAKDLRWLYLSDNEITNMQPGSLDE 194

  Fly   346 LTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRLRWIND---TELPRSMQMLDMRANPLST 406
            :..|.:..:|.|.:||.| ..:|||..:::|.|:.|.::.|.|   ....|.|:.|.|....:..
Frog   195 VENLAIFHMDGNQLSSYPLAAISKLRVVEDLKISRNPIKIIPDFAFQSFGRYMESLSMENMGVEK 259

  Fly   407 ISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471
            .|..||.|::                       .|:.|.::...:.::|||:...:  |:||.|.
Frog   260 FSDKAFVGVT-----------------------TLKTLNIEGNKLSQLPANVPYSS--LQSLALA 299

  Fly   472 TN 473
            .|
Frog   300 NN 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	52/203 (26%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	16/59 (27%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	38/151 (25%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	13/57 (23%)
		leucine-rich repeat	372..393	CDD:275380	5/23 (22%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	10/56 (18%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
chad	XP_017953398.1	LRRNT	22..>50	CDD:214470	7/25 (28%)
		leucine-rich repeat	54..77	CDD:275380	9/46 (20%)
		LRR_8	77..136	CDD:338972	16/58 (28%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		LRR	<105..>302	CDD:227223	55/222 (25%)
		leucine-rich repeat	126..149	CDD:275380	5/22 (23%)
		leucine-rich repeat	150..173	CDD:275380	6/22 (27%)
		leucine-rich repeat	174..197	CDD:275380	7/22 (32%)
		leucine-rich repeat	198..221	CDD:275380	9/22 (41%)
		leucine-rich repeat	222..245	CDD:275380	5/22 (23%)
		leucine-rich repeat	247..270	CDD:275380	7/45 (16%)
		LRRCT	301..348	CDD:214507	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910