Protein Alignment rk and NPY4R2

DIOPT Version :9

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: NP_001265724.1
• Gene: NPY4R2 / 100996758
• HGNCID: 52383
• Length: 375
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 71/316 - (22%)
• Similarity: 129/316 - (40%)
• Gaps: 61/316 - (19%)

  Fly   765 LLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGI----YLGILAIVDAATLGEFRMFAI 825
            ::.:|||..::.|.:..:.|.:|...|:.|||.:||.|.:    ...:..|:|....||
Human    53 VVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGE------ 111

  Fly   826 PWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALI 890
                 .||::|.|:..:|..:|:.:|.::.|||:..|.:.......:|....|.::.  ||.|.:
Human   112 -----TLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLI--WVIACV 169

  Fly   891 MALMPLVGVS-----DYRKFAVCLPFE------TTTGPAS---LTYVISLMFINGCAFL-TLMGC 940
            ::| |.:..|     .::..:..|.|.      |.:.|.:   ..|...|:....|..| .::.|
Human   170 LSL-PFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVC 233

  Fly   941 YLKMY--------------WAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQ 991
            |.::|              :::|.......|...:...:|..|.     |.|:..|:....:..:
Human   234 YARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVL-----WLPLHVFNSLEDWHHE 293

  Fly   992 LISLEQAK-IFTV--FVLPLNSCCNPFLYAIMTKQFKKD---CVTLCKH---FEES 1038
            .|.:.... ||.|  .:...::|.|||:|..:...|||:   .|..|:.   .|||
Human   294 AIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEES 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	33/130 (25%)
		7tm_1	770..1017	CDD:278431	61/282 (22%)
NPY4R2	NP_001265724.1	7tmA_NPY4R	42..333	CDD:320519	66/298 (22%)
		TM helix 1	43..69	CDD:320519	4/15 (27%)
		TM helix 2	76..101	CDD:320519	7/24 (29%)
		TM helix 3	114..144	CDD:320519	9/29 (31%)
		TM helix 4	155..176	CDD:320519	6/23 (26%)
		TM helix 5	211..240	CDD:320519	7/28 (25%)
		TM helix 6	258..288	CDD:320519	6/34 (18%)
		TM helix 7	301..326	CDD:320519	8/24 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910