DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Chadl

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_038936217.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	747	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	167/736 - (22%)
Similarity:	255/736 - (34%)	Gaps:	195/736 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PLLLQLLLQLLLLPPSAMGHDETKENPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITV 79
            |....|||.::.|.|:.    .......|..........:|..||  |...:.|.|:.:|:|...
  Rat    14 PQSFTLLLLMMFLSPAW----NVAAQRCPQTCVCDNSRRHVTCQH--QNLTEVPDTIPELTQRLD 72

  Fly    80 NRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSIC 144
            .:.:....:.|...::...|...|
  Rat    73 LQGNMLKVIPPAAFQDLPYLTHLD----------------------------------------- 96

  Fly   145 ERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELT 209
               || ||...   :|...:.||:|          .::.|:|.:|.|:.|...:.....:|..|.
  Rat    97 ---LQ-HCQVE---QVAEGAFRGLG----------RLLFLNLASNRLSSLPQEALDGLGSLRRLE 144

  Fly   210 LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHL 274
            |..|.:..:.|..|..|..|..|:|.:..|..||..:||||.:...|||:.|||..|..:.|..|
  Rat   145 LERNMLEELRPGTFGALGSLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNALSVLAPEALAGL 209

  Fly   275 QKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKIS 339
            ..||.|.|..|....:|..||:..|:|..|.||.|.||...:||...:|.|..|.|....:..:.
  Rat   210 PVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDHGSLQALG 274

  Fly   340 AGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRL---------------------- 382
            ..|..:...|..|:|..|.:::||. |....||:.|.:..|.|
  Rat   275 PRAFAHCPRLHTLDLRGNQLTTLPP-LQVPGQLRRLRLQGNPLWCACHARPLLEWLVRARVRSDG 338

  Fly   383 --------------------------------------------------RW----------IND 387
                                                              ||          :.:
  Rat   339 ACRGPRRLRGETLDTLRPSDLRCPGDAAEDEDEDRPAGPRSPPRSLHEEARWATPCPPACVCVGE 403

  Fly   388 TE---------------LPRSMQMLDMRAN------------------------PLSTISPGAFR 413
            |.               .|...|:||:|.|                        .::.:.|||..
  Rat   404 TRHSACDGRGLQAVPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPGALA 468

  Fly   414 GMSKLRKLILSDVR-TLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKR 477
            |:..|..|.||:.: :..|...||....|..|.|:......:|....|..|||.||.|:.|::.|
  Rat   469 GLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFLRIPGAALRALPRLFSLHLQDNAVDR 533

  Fly   478 IP--NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDL 540
            :.  :|:..|.||.|.||.|.|.::........::|..|.|..|:::.:|..|.:|:|.|:.|.|
  Rat   534 LAPGDLAGARALRGLYLSGNHITQVSPGALGPARELEKLHLDRNQLRQVPTGALEGLPALKELQL 598

  Fly   541 EGNEISYIHKEAFSGF-TALEDLNLGNNIFPELPE---SGLRALLHLKTFNNPKLREFPPPDTFP 601
            ..|....:|..||... .:|:.|.|.::...::..   |||...|........:|:..|.|....
  Rat   599 SRNPFRALHDGAFQPVGRSLQQLFLNSSDLEQISPRAFSGLGKGLQGLYLQQNQLQSLPAPMWLS 663

  Fly   602 RIQTLILS-YAYHC-CAFLPL 620
            .::.:.|| ..:|| |..|||
  Rat   664 GLELIDLSGNPFHCDCQLLPL 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	66/274 (24%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	23/58 (40%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	75/364 (21%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	21/175 (12%)
		leucine-rich repeat	372..393	CDD:275380	8/117 (7%)
		leucine-rich repeat	394..415	CDD:275380	8/44 (18%)
		leucine-rich repeat	418..486	CDD:275380	21/70 (30%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	19/57 (33%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	15/59 (25%)
		leucine-rich repeat	535..558	CDD:275380	7/23 (30%)
		leucine-rich repeat	559..580	CDD:275380	6/23 (26%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Chadl	XP_038936217.1	PLN00113	30..>555	CDD:215061	127/589 (22%)
		leucine-rich repeat	48..66	CDD:275380	6/19 (32%)
		leucine-rich repeat	68..91	CDD:275380	2/22 (9%)
		leucine-rich repeat	92..115	CDD:275380	10/80 (13%)
		leucine-rich repeat	116..139	CDD:275380	5/22 (23%)
		leucine-rich repeat	140..163	CDD:275380	7/22 (32%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	9/22 (41%)
		leucine-rich repeat	260..283	CDD:275380	4/22 (18%)
		leucine-rich repeat	306..345	CDD:275380	4/38 (11%)
		leucine-rich repeat	425..448	CDD:275380	5/22 (23%)
		PPP1R42	446..603	CDD:411060	45/156 (29%)
		leucine-rich repeat	449..472	CDD:275380	4/22 (18%)
		leucine-rich repeat	473..496	CDD:275380	7/22 (32%)
		leucine-rich repeat	497..520	CDD:275380	5/22 (23%)
		leucine-rich repeat	521..544	CDD:275380	7/22 (32%)
		leucine-rich repeat	545..568	CDD:275380	7/22 (32%)
		leucine-rich repeat	569..592	CDD:275380	7/22 (32%)
		LRR_8	591..653	CDD:404697	15/61 (25%)
		leucine-rich repeat	593..617	CDD:275380	7/23 (30%)
		leucine-rich repeat	618..641	CDD:275380	6/22 (27%)
		leucine-rich repeat	643..665	CDD:275380	4/21 (19%)
		leucine-rich repeat	666..677	CDD:275378	2/10 (20%)
		LRRCT	673..721	CDD:214507	6/12 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910