DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and opn4b

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001245153.1	Gene:	opn4b / 100884131	ZFINID:	ZDB-GENE-080415-3	Length:	565	Species:	Danio rerio

Alignment Length:	611	Identity:	123/611 - (20%)
Similarity:	204/611 - (33%)	Gaps:	150/611 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   743 PFLPCADLFD--WWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIY 805
            || |..|:.|  .:|:...:..|.:..::||..|::....|||........:.|||..||.|.:.
Zfish    57 PF-PTVDVPDHAHYTIGSVILAVGITGMVGNLLVMYAFCKSRSLRTPANMFIINLAVTDFLMCVT 120

  Fly   806 LGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNK 870
            .  ..|....:|.:..:|.     ...|:|..|...|....|:.||.:|.::|.:.||..:....
Zfish   121 Q--TPIFFTTSLHKRWIFG-----EKGCELYAFCGALFGICSMITLMIIAVDRYFVITRPLASIG 178

  Fly   871 RLSLKQAGYIMSVGWVFALIMALMPLVGVSDY---RKFAVCLPFETTTGPASLTYVISLM-FING 931
            .:|.|:|..|:|..|.:::..:|.|..|.|.|   .....|.....|..|:...|.:.|. |:..
Zfish   179 VMSRKRALLILSAAWAYSMGWSLPPFFGWSAYVPEGLLTSCSWDYMTFSPSVRAYTMLLFTFVFF 243

  Fly   932 CAFLTLMGCYLKMYWAIRGSQA-------------------WNTNDSRIAKRMALLVFTDFLCWS 977
            .....::.||..::.|||.:..                   ...|:.::||...:::....:.||
Zfish   244 IPLFVIIYCYFFIFKAIRETNRAVGKINGEGGPRDSIKKIHRMKNEWKMAKIALIVILLYVISWS 308

  Fly   978 PIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKD------------CVT 1030
            |.:..::||..|...:...........:...::..||.:|||...:::..            ||.
Zfish   309 PYSCVALTAFAGYADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYRSAIAKYIPCLGVLLCVP 373

  Fly  1031 LCKHFEESRVVGGGGPGGRGAVARTKRGDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQT 1095
            ....|..|..:.            |:|..|.......::..|..|...|..:......|...|..
Zfish   374 RRDRFSSSSFIS------------TRRSTLTSQSSETSSNLHRAGKARLSSVSDSESGWTDTEAD 426

  Fly  1096 PSMWQRLRTFCCGENRRRRKQRRQPQQRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSE--- 1157
            .|                                .|::.|...|              :|||
Zfish   427 LS--------------------------------TASSRPASRQ--------------VSSEIRK 445

  Fly  1158 NFCSSRSSSWRHGPPSSAPVPPGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLSSSR 1222
            :.|..:.||                |:.||:           :.|.|.  |..:||..|....|.
Zfish   446 DLCDIKHSS----------------SLRLKV-----------KSRDSG--IFDRTSAQSLADPST 481

  Fly  1223 NDSSASATTA----STSTFRLSRSSAGSSTPLPSIIAHNGKAQLDAVKPRLVRQEAVQEEEDSSP 1283
            |...|..:|.    ..|...:|.||.      ||...::...:.|..:| |||..::....::.|
Zfish   482 NRPCAYISTVGDKDEISMAEVSLSSC------PSSSQNDVSEKADEKRP-LVRIPSIIVTSETCP 539

  Fly  1284 PRL----GVRFLPTIPSAADSSVVME 1305
            ..|    ..|.:|..|:..||..|.:
Zfish   540 AVLPAGHSSRLIPGAPAVTDSVTVTD 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	32/127 (25%)
		7tm_1	770..1017	CDD:278431	59/269 (22%)
opn4b	NP_001245153.1	7tm_4	78..>305	CDD:304433	52/233 (22%)
opn4b	NP_001245153.1	7tm_1	85..348	CDD:278431	59/269 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910