DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lrrc8c

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_598658.1 Gene:Lrrc8c / 100604 MGIID:2140839 Length:803 Species:Mus musculus


Alignment Length:528 Identity:123/528 - (23%)
Similarity:191/528 - (36%) Gaps:135/528 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 MLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERW--------LQKHCHC 154
            |:...||      ||.|..          |...::|...|....::...|        ||.:.|.
Mouse   376 MIDQYDP------LYSKRF----------AVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHN 424

  Fly   155 TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAP-------NLEELTLSD 212
            ...|.::.||           .||:  .|.::......|||.....|.|       ||:||.|..
Mouse   425 RLELPLIMLS-----------GLPD--TVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQ 476

  Fly   213 NSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKL 277
            .|:........:....||.||::...::.|||..: ||..|..|.|.|:         |.|    
Mouse   477 CSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMY-GLRNLEELYLVGS---------LSH---- 527

  Fly   278 RTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIM------ 336
                   ::...:...:|..|::|:.|::.||:         .::|..:|.:....|.|      
Mouse   528 -------DISKNVTLESLRDLKSLKILSIKSNV---------SKIPQAVVDVSSHLQKMCVHNDG 576

  Fly   337 --KISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDM 399
              .:....||.:|.|..|||....:..:|..:..|..||||.:..|.|:.|.:            
Mouse   577 TKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEE------------ 629

  Fly   400 RANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPR 464
                                         :.||..|   ..|.:|||....|..:|.::.:.| .
Mouse   630 -----------------------------IVSFQHL---RKLTVLKLWYNSIAYIPEHIKKLT-S 661

  Fly   465 LKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNG-LKQLNDLLLSYNRIKALPQD 527
            |:.|....|.::.:| :|..|..:|.||||.|.|..|  .|..| |:.|....::.|::::|| |
Mouse   662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFI--PPEIGVLQSLQYFSITCNKVESLP-D 723

  Fly   528 AFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPEL-PESG-LRALLHLKTFNNPK 590
            ......||:.|.:..|.:|.:..: ......|..|::..|.|..| ||.| .|||..........
Mouse   724 ELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDA 787

  Fly   591 LREFPPPD 598
            |.|..|.|
Mouse   788 LFETLPSD 795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 4/20 (20%)
LRR_RI 180..>383 CDD:238064 51/217 (24%)
leucine-rich repeat 183..204 CDD:275380 6/27 (22%)
LRR_8 203..263 CDD:290566 20/66 (30%)
leucine-rich repeat 205..228 CDD:275380 5/22 (23%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
LRR_8 252..311 CDD:290566 12/58 (21%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 2/22 (9%)
LRR_8 299..359 CDD:290566 15/67 (22%)
leucine-rich repeat 301..324 CDD:275380 4/22 (18%)
leucine-rich repeat 325..348 CDD:275380 5/30 (17%)
LRR_RI 327..567 CDD:238064 58/249 (23%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
LRR_8 370..425 CDD:290566 7/54 (13%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 0/20 (0%)
leucine-rich repeat 418..486 CDD:275380 16/68 (24%)
leucine-rich repeat 441..464 CDD:275378 7/22 (32%)
LRR_8 487..545 CDD:290566 20/58 (34%)
leucine-rich repeat 487..510 CDD:275380 11/23 (48%)
leucine-rich repeat 511..534 CDD:275380 5/22 (23%)
LRR_8 533..589 CDD:290566 16/57 (28%)
leucine-rich repeat 535..558 CDD:275380 4/22 (18%)
leucine-rich repeat 559..580 CDD:275380 9/22 (41%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
Lrrc8cNP_598658.1 Pannexin_like 1..338 CDD:372171
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..206
LRR 1. /evidence=ECO:0000255 397..420 3/22 (14%)
LRR 2. /evidence=ECO:0000255 421..443 7/34 (21%)
LRR 3. /evidence=ECO:0000255 446..466 5/19 (26%)
LRR 4. /evidence=ECO:0000255 467..488 6/20 (30%)
LRR 5. /evidence=ECO:0000255 490..513 7/23 (30%)
leucine-rich repeat 493..515 CDD:275380 9/22 (41%)
LRR 6. /evidence=ECO:0000255 515..537 6/41 (15%)
leucine-rich repeat 516..543 CDD:275380 8/46 (17%)
LRR 528..>775 CDD:227223 71/304 (23%)
LRR 7. /evidence=ECO:0000255 541..563 7/30 (23%)
leucine-rich repeat 544..566 CDD:275380 6/30 (20%)
LRR 8. /evidence=ECO:0000255 566..586 2/19 (11%)
LRR 9. /evidence=ECO:0000255 588..611 6/22 (27%)
leucine-rich repeat 591..613 CDD:275380 6/21 (29%)
LRR 10. /evidence=ECO:0000255 613..635 9/62 (15%)
leucine-rich repeat 614..638 CDD:275380 10/67 (15%)
LRR 11. /evidence=ECO:0000255 637..659 6/21 (29%)
leucine-rich repeat 639..661 CDD:275380 7/22 (32%)
LRR 12. /evidence=ECO:0000255 660..682 6/22 (27%)
leucine-rich repeat 662..684 CDD:275380 6/21 (29%)
LRR 13. /evidence=ECO:0000255 684..705 10/22 (45%)
leucine-rich repeat 685..707 CDD:275380 11/23 (48%)
LRR 14. /evidence=ECO:0000255 706..728 5/22 (23%)
leucine-rich repeat 708..730 CDD:275380 5/22 (23%)
LRR 15. /evidence=ECO:0000255 730..751 5/21 (24%)
leucine-rich repeat 731..752 CDD:275380 4/21 (19%)
LRR 16. /evidence=ECO:0000255 752..774 8/21 (38%)
LRR 17. /evidence=ECO:0000255 776..799 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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