DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lrrc8c

DIOPT Version :10

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_598658.1 Gene:Lrrc8c / 100604 MGIID:2140839 Length:803 Species:Mus musculus


Alignment Length:528 Identity:123/528 - (23%)
Similarity:191/528 - (36%) Gaps:135/528 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 MLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERW--------LQKHCHC 154
            |:...||      ||.|..          |...::|...|....::...|        ||.:.|.
Mouse   376 MIDQYDP------LYSKRF----------AVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHN 424

  Fly   155 TGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAP-------NLEELTLSD 212
            ...|.::.||           .||:  .|.::......|||.....|.|       ||:||.|..
Mouse   425 RLELPLIMLS-----------GLPD--TVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQ 476

  Fly   213 NSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKL 277
            .|:........:....||.||::...::.|||..: ||..|..|.|.|:         |.|    
Mouse   477 CSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMY-GLRNLEELYLVGS---------LSH---- 527

  Fly   278 RTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIM------ 336
                   ::...:...:|..|::|:.|::.||:         .::|..:|.:....|.|      
Mouse   528 -------DISKNVTLESLRDLKSLKILSIKSNV---------SKIPQAVVDVSSHLQKMCVHNDG 576

  Fly   337 --KISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDM 399
              .:....||.:|.|..|||....:..:|..:..|..||||.:..|.|:.|.:            
Mouse   577 TKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEE------------ 629

  Fly   400 RANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPR 464
                                         :.||..|   ..|.:|||....|..:|.::.:.| .
Mouse   630 -----------------------------IVSFQHL---RKLTVLKLWYNSIAYIPEHIKKLT-S 661

  Fly   465 LKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNG-LKQLNDLLLSYNRIKALPQD 527
            |:.|....|.::.:| :|..|..:|.||||.|.|..|  .|..| |:.|....::.|::::|| |
Mouse   662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFI--PPEIGVLQSLQYFSITCNKVESLP-D 723

  Fly   528 AFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPEL-PESG-LRALLHLKTFNNPK 590
            ......||:.|.:..|.:|.:..: ......|..|::..|.|..| ||.| .|||..........
Mouse   724 ELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDA 787

  Fly   591 LREFPPPD 598
            |.|..|.|
Mouse   788 LFETLPSD 795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 LRR <157..390 CDD:443914 58/247 (23%)
leucine-rich repeat 158..179 CDD:275380 4/20 (20%)
leucine-rich repeat 183..204 CDD:275380 6/27 (22%)
leucine-rich repeat 205..228 CDD:275380 5/22 (23%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 2/22 (9%)
LRR 292..612 CDD:443914 78/319 (24%)
leucine-rich repeat 301..324 CDD:275380 4/22 (18%)
leucine-rich repeat 325..348 CDD:275380 5/30 (17%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 0/20 (0%)
leucine-rich repeat 418..486 CDD:275380 16/68 (24%)
leucine-rich repeat 441..464 CDD:275378 7/22 (32%)
leucine-rich repeat 487..510 CDD:275380 11/23 (48%)
leucine-rich repeat 511..534 CDD:275380 5/22 (23%)
leucine-rich repeat 535..558 CDD:275380 4/22 (18%)
leucine-rich repeat 559..580 CDD:275380 9/22 (41%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264
TM helix 1 755..781 CDD:320264
TM helix 2 788..813 CDD:320264
TM helix 3 833..863 CDD:320264
TM helix 4 875..897 CDD:320264
TM helix 5 918..947 CDD:320264
TM helix 6 956..986 CDD:320264
TM helix 7 996..1021 CDD:320264
Lrrc8cNP_598658.1 Pannexin_like 1..338 CDD:463622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..206
LRR 1. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 409..420 2/10 (20%)
LRR 2. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 421..443 7/34 (21%)
LRR 3. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 446..466 5/19 (26%)
LRR 4. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 467..488 6/20 (30%)
LRR 5. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 490..513 7/23 (30%)
leucine-rich repeat 493..515 CDD:275380 9/22 (41%)
PPP1R42 <512..622 CDD:455733 31/138 (22%)
LRR 6. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 515..537 6/41 (15%)
leucine-rich repeat 516..543 CDD:275380 8/46 (17%)
LRR 7. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 541..563 7/30 (23%)
leucine-rich repeat 544..566 CDD:275380 6/30 (20%)
LRR 8. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 566..586 2/19 (11%)
LRR <582..>772 CDD:443914 60/238 (25%)
LRR 9. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 588..611 6/22 (27%)
leucine-rich repeat 591..613 CDD:275380 6/21 (29%)
LRR 10. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 613..635 9/62 (15%)
leucine-rich repeat 614..638 CDD:275380 10/67 (15%)
LRR 11. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 637..659 6/21 (29%)
leucine-rich repeat 639..661 CDD:275380 7/22 (32%)
LRR 12. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 660..682 6/22 (27%)
leucine-rich repeat 662..684 CDD:275380 6/21 (29%)
LRR 13. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 684..705 10/22 (45%)
leucine-rich repeat 685..707 CDD:275380 11/23 (48%)
LRR 14. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 706..728 5/22 (23%)
leucine-rich repeat 708..730 CDD:275380 5/22 (23%)
LRR 15. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 730..751 5/21 (24%)
leucine-rich repeat 731..752 CDD:275380 4/21 (19%)
LRR 16. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 752..774 8/21 (38%)
LRR 17. /evidence=ECO:0000255, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK 776..799 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

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