DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	495	Identity:	116/495 - (23%)
Similarity:	184/495 - (37%)	Gaps:	142/495 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 LNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP-EGLS 367
            |||..|.:.:|..:.|..:.:|.:|.|.:|||.:|..||...|..|..|||.||.:..:| :...
Zfish    73 LNLQENSIQVIRSDTFKHLNHLEILQLSKNQIRQIEVGAFNGLPNLITLELFDNRLPLVPSQAFE 137

  Fly   368 KLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSF 432
            .||:|:||        |              :|.||:.|:...||..:..||:|.|.::|.|...
Zfish   138 YLSKLREL--------W--------------LRNNPIETLPAYAFHRVPSLRRLDLGELRKLSFI 180

  Fly   433 PE--LEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSN 495
            .|  .|....|..|.|...|                        ||.:|||:....|..|:||.|
Zfish   181 SEAAFEGLLNLRFLNLGMCG------------------------LKDVPNLTPLVRLEELELSGN 221

  Fly   496 QIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALE 560
            |:..::...|.||..|..|.|.::||..:.::||..:..|:.|:|..|.:..:..:.|:....||
Zfish   222 QLGVVRPGSFQGLVSLRKLWLMHSRISVIERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQQLE 286

  Fly   561 DLNLGNN--------------IFPELPE-SGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSY 610
            .::|.:|              :...:|: |...|..|            .||.|..|....:...
Zfish   287 RVHLNHNPWVCNCDVLWLSWWLKETVPDNSTCCARCH------------APPGTKGRYIGDLDQR 339

  Fly   611 AYHCCAFLPLV-----------AMSSQKK----TSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQM 660
            .:.|  :.|::           .|:::.|    ||......|.|          |.::|.
Zfish   340 DFTC--YAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTP----------NGTLMT----- 387

  Fly   661 HNLSKQLGASMHDPWETAINFNEEQLQ----------TQTGGQIATSYMEEYFEEHDVSGPATGY 715
            |...|...:.:||   ..:||....:|          ...|...||:.:       :||.|..|.
Zfish   388 HGAYKVRISVLHD---GTLNFTNVTMQDTGPYTCMVTNSAGNTTATAVL-------NVSAPDPGN 442

  Fly   716 GFGTGLFSGMSTEDFQPG------------SVQCLPMPGP 743
            |:  ..|:.::.|..:.|            :...:..|||
Zfish   443 GY--SYFTTVTVETVETGQEGHDSPARQFVNETFISFPGP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	28/79 (35%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	4/6 (67%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	22/54 (41%)
		leucine-rich repeat	301..324	CDD:275380	6/19 (32%)
		leucine-rich repeat	325..348	CDD:275380	10/22 (45%)
		LRR_RI	327..567	CDD:238064	69/242 (29%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	15/54 (28%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	17/69 (25%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	13/70 (19%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	6/35 (17%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470
		LRR_8	68..128	CDD:290566	22/54 (41%)
		leucine-rich repeat	70..93	CDD:275380	6/19 (32%)
		LRR_RI	85..293	CDD:238064	71/253 (28%)
		leucine-rich repeat	94..117	CDD:275380	10/22 (45%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR_8	140..196	CDD:290566	21/77 (27%)
		leucine-rich repeat	142..165	CDD:275380	10/44 (23%)
		leucine-rich repeat	166..190	CDD:275380	8/23 (35%)
		leucine-rich repeat	191..212	CDD:275380	9/44 (20%)
		LRR_8	212..271	CDD:290566	20/58 (34%)
		leucine-rich repeat	213..236	CDD:275380	9/22 (41%)
		leucine-rich repeat	237..260	CDD:275380	7/22 (32%)
		leucine-rich repeat	261..282	CDD:275380	5/20 (25%)
		TPKR_C2	293..343	CDD:301599	9/61 (15%)
		IG_like	352..435	CDD:214653	18/107 (17%)
		Ig	360..435	CDD:299845	18/99 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910