DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and LOC100535105

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_009298331.1	Gene:	LOC100535105 / 100535105	-ID:	-	Length:	706	Species:	Danio rerio

Alignment Length:	495	Identity:	126/495 - (25%)
Similarity:	202/495 - (40%)	Gaps:	80/495 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 ATDVIAGKRTLH----SICE--RWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGN 188
            ||.|||.:..:.    .:||  .|...   .:..:|...:.|..:|:..:|..||.:..||.|..
Zfish    17 ATFVIAAEEKISCPKLCVCEIRPWFSP---SSVYMEAPTIDCNDLGLFKLPTRLPLDTQVLLLQT 78

  Fly   189 NNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQL 253
            ||:.|.|....::. |:.|:.||.|::                .|:.:..:.|||        ||
Zfish    79 NNIAKNEHPLDYLT-NITEIDLSQNNL----------------SSINDINIGSLP--------QL 118

  Fly   254 TSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDED 318
            .||.:..|.:.||..:.|..|..|:.|.|..||...|...|..||::|..|:|.||.|.||..|.
Zfish   119 LSLHMEENWICSLPDNSLSQLTNLQELYLNHNLISLISPEAFRGLQSLLRLHLNSNRLQIIKSEW 183

  Fly   319 FPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRL 382
            |..:|||.:|::..|.::.|.....|.|..|:.|.|....:|.:| :....|..|:.:|...|..
Zfish   184 FEPLPNLEILMIGENPVLSIQDMNFKPLRNLRSLVLTRMNLSQIPDDSFLGLDNLESISFYDNTF 248

  Fly   383 RWINDTELP--RSMQMLDMRANPLSTISPGAF--------RGMSKLRKLILSDVRTLRSFPELEA 437
            ..:....|.  :|::.||:..||:..|..|.|        .|::.:.:|:..|...|.:.|||..
Zfish   249 PKVPHGALRHLKSLKFLDLNKNPIGRIQRGDFVDMLHLKELGINSMPELVSIDSFALNNLPELTK 313

  Fly   438 CHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLS--SCRDLRLLDLSSNQIEKI 500
            ..|....||     ..:..|...:.|||::|.|..|:|..:..::  |..:||.:.:.||.|...
Zfish   314 IEATNNPKL-----SYIHPNAFYRLPRLETLMLNGNALSALHRITVESLPNLREVSMHSNPIRCD 373

  Fly   501 QGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLG 565
            ....:..:.:.|...:.       |...|...|.    :.||..:..:|      |..:.::.|.
Zfish   374 CVVRWMNMNKTNIRFME-------PDSLFCVEPP----EYEGQHVRQVH------FREMMEICLP 421

  Fly   566 NNIFPELP-----ESGLRALLHLKTFNNPKLREFPPPDTF 600
            ......||     :.|....||.:.|..|:      ||.:
Zfish   422 LISSESLPTQISMDRGRSVSLHCRAFAEPE------PDIY 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	61/203 (30%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	14/59 (24%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_8	252..311	CDD:290566	23/58 (40%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	56/252 (22%)
		leucine-rich repeat	349..371	CDD:275380	6/22 (27%)
		LRR_8	370..425	CDD:290566	14/64 (22%)
		leucine-rich repeat	372..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..415	CDD:275380	7/28 (25%)
		leucine-rich repeat	418..486	CDD:275380	18/69 (26%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	11/57 (19%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	12/60 (20%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	4/25 (16%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LOC100535105	XP_009298331.1	leucine-rich repeat	52..70	CDD:275380	5/17 (29%)
		leucine-rich repeat	71..93	CDD:275380	7/22 (32%)
		LRR_RI	88..>273	CDD:238064	60/209 (29%)
		leucine-rich repeat	95..117	CDD:275380	8/45 (18%)
		LRR_8	116..176	CDD:290566	24/67 (36%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		LRR_8	165..221	CDD:290566	21/55 (38%)
		leucine-rich repeat	166..189	CDD:275380	10/22 (45%)
		leucine-rich repeat	190..213	CDD:275380	6/22 (27%)
		LRR_8	212..272	CDD:290566	14/59 (24%)
		leucine-rich repeat	214..237	CDD:275380	6/22 (27%)
		leucine-rich repeat	238..261	CDD:275380	4/22 (18%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR_8	309..370	CDD:290566	19/65 (29%)
		leucine-rich repeat	311..333	CDD:275380	5/26 (19%)
		leucine-rich repeat	336..357	CDD:275380	5/20 (25%)
		leucine-rich repeat	360..372	CDD:275378	5/11 (45%)
		LRRCT	368..411	CDD:214507	8/53 (15%)
		IG_like	429..513	CDD:214653	8/33 (24%)
		Ig	437..513	CDD:299845	7/25 (28%)
		fn3	518..593	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910