DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and rxfp1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001177863.1	Gene:	rxfp1 / 100498669	ZFINID:	ZDB-GENE-110125-1	Length:	748	Species:	Danio rerio

Alignment Length:	977	Identity:	219/977 - (22%)
Similarity:	321/977 - (32%)	Gaps:	371/977 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|..    |.|.|.|.....||:...| |.::.|..|.|.||.|:.|....:|::|.|..|.|
Zfish   101 CQCRD----LELDCDGAHFKDVPMVSIN-VTMMSLQRNGLRKLNADMFLKYQSLQKLYLQHNRI- 159

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
                                   ||:.||:|:||..||.|.|:.|.:.:|..|....|.||..|.
Zfish   160 -----------------------KSVHPQAFRGLYNLTRLYLSYNRITTLLPDVFQDLHKLEWLI 201

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            ||.|..:.|.:...:|||                        :|::|:|..|.:.|:
Zfish   202 LENNSLHHISSLTFSGLR------------------------SLVLLVLLNNALTKL-------- 234

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGA 411
                     |::...:|                 ||.|            ||:..|.:.|:....
Zfish   235 ---------DDICLEMP-----------------RLNW------------LDIEGNKMETVGNVT 261

  Fly   412 FRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLK 476
            ||                       :|:.|.:|.|.|..|..:.|..
Zfish   262 FR-----------------------SCNMLTVLVLQRNRISRIHAQA------------------ 285

  Fly   477 RIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLE 541
                .|..|.|..||||||:||.|....|..|..|..|.:|||.|..|..|.|..:.||:.|.:|
Zfish   286 ----FSLLRKLGELDLSSNRIEAIPPDLFVNLGDLLQLNISYNPIMNLRVDHFDKLHKLKSLSIE 346

  Fly   542 GNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTL 606
            |.||..||:..|                     ..|:.|.|:
Zfish   347 GIEIGNIHRRMF---------------------EPLKNLTHI----------------------- 367

  Fly   607 ILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASM 671

Zfish   368 ----------------------------------------------------------------- 367

  Fly   672 HDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQ 736
                                          ||::....|                   :.|....
Zfish   368 ------------------------------YFKKFQYCG-------------------YAPYVRS 383

  Fly   737 CLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFF 801
            |.|.........||.....||..||.|...:..||..|:.:....||:..:....:.:|..||..
Zfish   384 CKPNTDGISSFEDLLANIVLRVFVWAVSATTCFGNIFVICMRSYIRSENKLHAMCIISLCCADGL 448

  Fly   802 MGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHA- 865
            ||:||.::...|....||:...|.....|..||:.|.||:||:|:||..|..:|||:...|.:.
Zfish   449 MGVYLFMIGAYDLKFRGEYNRHAQAGMDSEACQVIGSLAMLSTEVSVLLLTYLTLEKYICIVYPF 513

  Fly   866 --IHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKF----AVCLPFET----TTGPASL 920
              :.|.:|.::.    |:.|.||...|:|.:||:....:|.|    .||.|..:    |.| |.:
Zfish   514 RYLTLGRRRTVT----ILVVIWVLGFIIAFLPLLFKGVFRNFYGTNGVCFPLHSEQPETLG-AQI 573

  Fly   921 TYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSR-------IAKRMALLVFTDFLCWSP 978
            ..::..:.:|..|||.::..|..|::.|:.:....|..|.       ||||...:|.||.|||.|
Zfish   574 YSIVIFLGLNLVAFLIIVLSYGSMFYNIQRTGTQTTKYSNHIKKELTIAKRFFSIVITDSLCWIP 638

  Fly   979 IAFFSITAIFGLQLISLEQAKI-------FTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFE 1036
                    ||.|:.:||.:.:|       ..:|:||:||..||.||.:.|:.||:..:.:..::.
Zfish   639 --------IFILKTLSLMEVEIPGTISSWVVIFILPINSALNPILYTLTTRPFKETLLQVWSNYR 695

  Fly  1037 ESRVVGGGGPGGRGAVARTKRGDLPPPLLPA--------------AAVAHPPG-CRCLRMLPSEM 1086
            :.|.:...                .||.||:              ...:||.. |....:||.|.
Zfish   696 QRRPLFSS----------------RPPHLPSFTWQEMWPLQENSQTLCSHPSDICNTTHLLPVEA 744

  Fly  1087 PN 1088
            .|
Zfish   745 SN 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	46/202 (23%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	18/58 (31%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	7/59 (12%)
		leucine-rich repeat	301..324	CDD:275380	0/22 (0%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	55/239 (23%)
		leucine-rich repeat	349..371	CDD:275380	2/21 (10%)
		LRR_8	370..425	CDD:290566	9/54 (17%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	8/67 (12%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	26/57 (46%)
		leucine-rich repeat	487..510	CDD:275380	12/22 (55%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	13/55 (24%)
		leucine-rich repeat	535..558	CDD:275380	9/22 (41%)
		leucine-rich repeat	559..580	CDD:275380	1/20 (5%)
		7tm_4	764..>892	CDD:304433	39/130 (30%)
		7tm_1	770..1017	CDD:278431	83/271 (31%)
rxfp1	NP_001177863.1	LDLa	29..64	CDD:238060
		LRR_RI	99..304	CDD:238064	80/346 (23%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		LRR_8	148..207	CDD:290566	26/82 (32%)
		leucine-rich repeat	149..172	CDD:275380	12/46 (26%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	196..278	CDD:290566	31/174 (18%)
		leucine-rich repeat	197..220	CDD:275380	9/46 (20%)
		leucine-rich repeat	221..243	CDD:275380	7/55 (13%)
		leucine-rich repeat	244..267	CDD:275380	9/57 (16%)
		LRR_8	268..326	CDD:290566	25/79 (32%)
		leucine-rich repeat	268..291	CDD:275380	7/44 (16%)
		leucine-rich repeat	292..315	CDD:275380	12/22 (55%)
		leucine-rich repeat	316..339	CDD:275380	9/22 (41%)
		leucine-rich repeat	340..361	CDD:275380	9/41 (22%)
		7tm_1	417..676	CDD:278431	83/271 (31%)
		7tm_4	<482..>616	CDD:304433	40/138 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910