DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and slitrk4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_004916941.2	Gene:	slitrk4 / 100497316	XenbaseID:	XB-GENE-983538	Length:	851	Species:	Xenopus tropicalis

Alignment Length:	583	Identity:	146/583 - (25%)
Similarity:	203/583 - (34%)	Gaps:	174/583 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 ICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEE 207
            |..|.|:..|||......|.|      .|..|::..|....|.|...|:....:....|..|.|:
Frog     2 ISPRSLRLFCHCQKMFVWLFL------FLCTPISSTNPDSELSLEICNVCSCLSVENVMYVNCEK 60

  Fly   208 LTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLG 272
            :.|...:.:...|:.||      .|:.||..|..|.|.:|.......||||..|.|.:::|
Frog    61 VALYRPNQLKPPPSNFY------HLNFQNNLLIILYPNTFLNFTHAVSLQLGNNKLQNIEG---- 115

  Fly   273 HLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMK 337
                                .|..||..|:.|:|.:|.|.::..:.|..:.||..|....|.|..
Frog   116 --------------------GAFQGLSALKQLHLNNNELKVLRADTFLGIENLEYLQADYNLIKY 160

  Fly   338 ISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLR------------------- 383
            |..||...|..||||.|:|||||:||:.:.:.:.|..|.|..||::
Frog   161 IERGAFNKLHKLKVLILNDNLISALPDNIFRFASLTHLDIRGNRIQKMPYIGVLEHIGRVVELQL 225

  Fly   384 ----------------WIND-----------TELPRSM----------QML---------DMRAN 402
                            |:.:           .|.|..:          |.|         |:|..
Frog   226 EDNPWNCTCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCSMGTGSDFDVRIL 290

  Fly   403 PLST----ISPGAFRGMSKLRKLI-------------------------LSDV------------ 426
            |.|.    .:||.....:.|.:|:                         ||.:
Frog   291 PPSMETTFTTPGGQPAQTSLHRLVTKAPKTTNPSKNSGIVSGKSVSNHSLSQIVSFQTRIPPFSP 355

  Fly   427 ----------------------RTLRSFPELEACHALEILKLDRAG--IQEVPANLCRQTPRLKS 467
                                  |.::|..|| ....|...||...|  |:.|..:.......|..
Frog   356 CPSPCMCKTYPSDLGLSVNCQERNIKSMAEL-IPKPLNAKKLHVNGNYIKHVEQSDFVDFEGLDL 419

  Fly   468 LELKTNSLKRIPNLSSCR--DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQ 530
            |.|.:|.|..|.....|.  :||.|.|:.||||::..:.|.||..|..|.|.||.||.:....|:
Frog   420 LHLGSNQLTNIQGNVFCNLTNLRRLYLNGNQIERLSPEIFAGLHNLQYLYLEYNIIKEILGGTFE 484

  Fly   531 GIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESG----LRALLHLKTFNNP 589
            .:|.||||.|..|.:..:....||| ..|..||:.||.|..||.||    ||:|..:....||
Frog   485 SMPNLQLLYLNNNLLRSLPAYIFSG-VPLARLNIRNNHFMYLPVSGVLDQLRSLTQIDLEGNP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	59/202 (29%)
		leucine-rich repeat	183..204	CDD:275380	4/20 (20%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	14/58 (24%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	3/22 (14%)
		LRR_8	299..359	CDD:290566	22/59 (37%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	88/371 (24%)
		leucine-rich repeat	349..371	CDD:275380	12/21 (57%)
		LRR_8	370..425	CDD:290566	19/148 (13%)
		leucine-rich repeat	372..393	CDD:275380	8/66 (12%)
		leucine-rich repeat	394..415	CDD:275380	8/43 (19%)
		leucine-rich repeat	418..486	CDD:275380	21/130 (16%)
		leucine-rich repeat	441..464	CDD:275378	6/24 (25%)
		LRR_8	487..545	CDD:290566	26/57 (46%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	23/59 (39%)
		leucine-rich repeat	535..558	CDD:275380	9/22 (41%)
		leucine-rich repeat	559..580	CDD:275380	12/24 (50%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
slitrk4	XP_004916941.2	internalin_A	<30..>268	CDD:380193	63/267 (24%)
		leucine-rich repeat	78..99	CDD:275380	7/20 (35%)
		LRR_8	102..158	CDD:404697	20/79 (25%)
		leucine-rich repeat	102..123	CDD:275380	10/44 (23%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_8	147..205	CDD:404697	25/57 (44%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..194	CDD:275380	12/21 (57%)
		leucine-rich repeat	195..219	CDD:275380	5/23 (22%)
		leucine-rich repeat	220..312	CDD:275380	12/91 (13%)
		leucine-rich repeat	313..416	CDD:275380	13/103 (13%)
		leucine-rich repeat	372..392	CDD:275380	4/20 (20%)
		PPP1R42	373..546	CDD:411060	59/174 (34%)
		LRR_8	416..473	CDD:404697	21/56 (38%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		leucine-rich repeat	441..464	CDD:275380	11/22 (50%)
		leucine-rich repeat	465..486	CDD:275380	8/20 (40%)
		leucine-rich repeat	489..510	CDD:275380	9/21 (43%)
		leucine-rich repeat	512..536	CDD:275380	11/23 (48%)
		TPKR_C2	545..>577	CDD:417692	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910