DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and tlr8

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002933859.2	Gene:	tlr8 / 100496108	XenbaseID:	XB-GENE-485083	Length:	1037	Species:	Xenopus tropicalis

Alignment Length:	687	Identity:	159/687 - (23%)
Similarity:	257/687 - (37%)	Gaps:	179/687 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKS 115
            :|.::....|.:..|..|.|||.||....|..|         :::.::.|..:.:|   :....:
Frog   127 EELFIDHNFLCKIPQGIPSTVQTLSLSYNNIFS---------VKKQILSPLINLKK---LFLNHN 179

  Fly   116 LQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNE 180
            .  |.|::   .....|:..|  |...:.|            |.||.||..  .:..||..||..
Frog   180 C--YFGNE---CDHVVDIEEG--TFAGLTE------------LTVLDLSFN--NMTRVPAKLPAS 223

  Fly   181 VVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNS-----------------IINMDPNAFYGLAK 228
            :..|.|.|||:..:.::......|||.|.|:.|.                 .|.:||.||..|..
Frog   224 LKELYLSNNNIQIIHSDDLQNLINLEVLFLNGNCPRCFNANYPCKNLCKQISITIDPLAFQNLKN 288

  Fly   229 LKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVS--LDGDCLGHLQKLRTLRLEGNLFYRIP 291
            |..|.|.:..|:::||..||...||..|.|..|.||:  ...|.|.:|..|..|.|..|...|..
Frog   289 LTELHLGSTSLRTIPPIWFQNTTQLKILNLQLNYLVNEIASADFLLNLPFLEVLDLSFNYDLRSY 353

  Fly   292 TNAL------AGLRTLEALNL---------GSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAG 341
            .|.:      :.|.:|:.|::         ..||..:||      :|.|..:.|..|.|.::...
Frog   354 ANNINISNHFSKLISLQELHIQGYVFKHIAAKNLSPLIN------LPKLATINLGINFIKQVDFE 412

  Fly   342 ALKNLTALKVLELDDNLISSLPEGLSKL---------------------SQLQELSITSNRLRWI 385
            ..:|::.||::.|.:|.|:...|...:|                     |..|...|.|:.::
Frog   413 VFQNISGLKLIYLSENRITPFSETNKQLFGVCKDQSYRISSPGVTFPTQSNFQMTKIFSHLVK-- 475

  Fly   386 NDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILS-----------DVRTLRSFPELEACH 439
              .:.....:.||:..|.:..|.|..||..|.:..|.||           :...|::...|:
Frog   476 --PQCSSRGKTLDLSLNSIFFIDPEEFRSFSDVSCLNLSFNSIGQDLNGTEFIYLKNLTYLD--- 535

  Fly   440 ALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS-----------LKRIPNL------------ 481
             |...|||...|     |..::.|.|:.|:|..||           ||.|.||
Frog   536 -LSFNKLDFDSI-----NAFQELPSLEVLDLSYNSHYFIVDGVTHRLKFIENLQYLKVLNLSWNK 594

  Fly   482 -SSCRDLRL-------LDLSSNQI-------EKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQG 531
             |:..|.||       |..|.|::       :|...:.|..|..|..|.:||||:..:.:.....
Frog   595 ISTLTDFRLTSHSLKELQFSGNRLDVLWKNEDKRYQELFKNLYNLTCLDISYNRLNKMTEVELSN 659

  Fly   532 IP-KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFP 595
            :| .|..|.|..|::.|...:|...:..|:.|:|.:|..     :.:...|.:.|::
Frog   660 LPLSLTELYLNNNKLDYFGWKALKAYKNLKHLDLSHNKL-----TMIMGNLSIHTYS-------- 711

  Fly   596 PPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQV 632
                   :.:||:|  |:..:.||:..:...:..|::
Frog   712 -------LSSLIIS--YNSISSLPVAFLHKSRNLSEL 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	65/257 (25%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	25/76 (33%)
		leucine-rich repeat	205..228	CDD:275380	11/39 (28%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	20/75 (27%)
		leucine-rich repeat	253..276	CDD:275380	9/24 (38%)
		leucine-rich repeat	277..300	CDD:275380	7/28 (25%)
		LRR_8	299..359	CDD:290566	16/68 (24%)
		leucine-rich repeat	301..324	CDD:275380	6/31 (19%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	71/310 (23%)
		leucine-rich repeat	349..371	CDD:275380	7/42 (17%)
		LRR_8	370..425	CDD:290566	15/65 (23%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	23/102 (23%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	19/72 (26%)
		leucine-rich repeat	487..510	CDD:275380	8/36 (22%)
		leucine-rich repeat	511..534	CDD:275380	7/23 (30%)
		LRR_8	533..589	CDD:290566	13/56 (23%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
tlr8	XP_002933859.2	leucine-rich repeat	45..64	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		leucine-rich repeat	88..125	CDD:275380
		leucine-rich repeat	126..145	CDD:275380	3/17 (18%)
		PLN00113	132..>563	CDD:215061	115/482 (24%)
		leucine-rich repeat	147..170	CDD:275380	7/31 (23%)
		leucine-rich repeat	171..202	CDD:275380	6/40 (15%)
		leucine-rich repeat	203..223	CDD:275380	9/21 (43%)
		leucine-rich repeat	224..247	CDD:275380	5/22 (23%)
		leucine-rich repeat	248..288	CDD:275380	11/39 (28%)
		leucine-rich repeat	289..312	CDD:275380	8/22 (36%)
		leucine-rich repeat	313..338	CDD:275380	9/24 (38%)
		leucine-rich repeat	339..368	CDD:275380	7/28 (25%)
		leucine-rich repeat	400..419	CDD:275380	4/18 (22%)
		leucine-rich repeat	483..505	CDD:275380	7/21 (33%)
		leucine-rich repeat	509..530	CDD:275380	4/20 (20%)
		leucine-rich repeat	531..554	CDD:275380	7/31 (23%)
		leucine-rich repeat	555..584	CDD:275380	10/28 (36%)
		leucine-rich repeat	585..607	CDD:275380	4/21 (19%)
		PPP1R42	588..772	CDD:411060	36/174 (21%)
		leucine-rich repeat	608..638	CDD:275380	6/29 (21%)
		leucine-rich repeat	639..663	CDD:275380	7/23 (30%)
		leucine-rich repeat	664..687	CDD:275380	6/22 (27%)
		leucine-rich repeat	688..711	CDD:275380	6/27 (22%)
		leucine-rich repeat	712..735	CDD:275380	6/24 (25%)
		leucine-rich repeat	736..754	CDD:275380	1/4 (25%)
		TPKR_C2	770..>809	CDD:417692
		TIR_2	877..1014	CDD:419986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910