DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and XB5889249

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017950848.2	Gene:	XB5889249 / 100495326	XenbaseID:	XB-GENE-5889250	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	121/504 - (24%)
Similarity:	197/504 - (39%)	Gaps:	122/504 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 HCTGSLEVLRLSCRGIGILAVPVNLPN-EVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            :|...|.:|.||...||.|...|...| .:..||:.||.|..::.:|.....|::.:.||.|:..
Frog    66 NCFLQLRLLNLSHNLIGELDCSVFKFNPSLEYLDISNNRLHTIKCHSLQYIKNIKRMDLSYNNFK 130

  Fly   217 NMD-PNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCL--------- 271
            .|| .:.|..|::||.|.|.:   |.:...||..:|             |:|.|.:
Frog   131 TMDFCSEFTALSQLKHLGLSS---KKIQKDSFINIA-------------SMDLDFVFLGIENEIE 179

  Fly   272 ---GHLQKLRTLRLEGNLFYRIP-------TNALAGLRTLE------------------ALNLGS 308
               |.||.|.|.:|..||...:.       ::||....|||                  .:|..|
Frog   180 YENGSLQFLNTNKLHINLQPNLSLASSYLLSDALDTSMTLEVSGAQCDVHCDYFTKSFFTINKNS 244

  Fly   309 NLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQ 373
            .::.:|....  .||.        |:::||            :..:.|:.:..|...:.:|  ::
Frog   245 KVVNLIISNS--TMPG--------NEMLKI------------IPPIWDSSVEHLHIKMFRL--IK 285

  Fly   374 EL----------SITSNRLRWI-NDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVR 427
            |.          ||.|..|.:. ||....:.....::.|..|             :..:..|:..
Frog   286 EFKYVKMDFTHHSIKSFTLEYFTNDVFFFQGTHPFNIFAEML-------------VENVTFSNAG 337

  Fly   428 TLRSF-PELEACHALEILKLDRAGI-QEVPANLCRQTPRLKSLELKTNSLKRIPNLSS----CRD 486
            .:..| |.:.:  .:..|.|....| .|:..| |.....|:.|.|:.|.|:::..:||    .::
Frog   338 MIHFFCPPVPS--IVRFLNLPSNRITDEIFLN-CSSLNELELLNLQNNKLEQMSKISSMTLKMKN 399

  Fly   487 LRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP-KLQLLDLEGNEISYIHK 550
            |:.||||.|.:.....|..|.:..|..|.||.:   .|....|..:| .||:|||..|:||.|..
Frog   400 LKHLDLSKNGLHIDNEKQCNWMDSLVFLNLSES---GLTNSVFGCLPINLQILDLSKNQISSIPI 461

  Fly   551 EAFSGFTALEDLNLGNNIFPELPE-----SGLRALLHLKTFNNPKLREF 594
            |. ..|.:|::|:|.:|...::|:     :.|..|...:.|.|...:||
Frog   462 EV-KNFVSLKELHLASNRLTDIPDCHNIGNNLGVLKVDENFINLPPKEF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	53/250 (21%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	16/60 (27%)
		leucine-rich repeat	205..228	CDD:275380	7/23 (30%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	18/95 (19%)
		leucine-rich repeat	253..276	CDD:275380	5/34 (15%)
		leucine-rich repeat	277..300	CDD:275380	7/29 (24%)
		LRR_8	299..359	CDD:290566	12/77 (16%)
		leucine-rich repeat	301..324	CDD:275380	6/40 (15%)
		leucine-rich repeat	325..348	CDD:275380	3/22 (14%)
		LRR_RI	327..567	CDD:238064	60/257 (23%)
		leucine-rich repeat	349..371	CDD:275380	3/21 (14%)
		LRR_8	370..425	CDD:290566	9/65 (14%)
		leucine-rich repeat	372..393	CDD:275380	7/31 (23%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	16/73 (22%)
		leucine-rich repeat	441..464	CDD:275378	6/23 (26%)
		LRR_8	487..545	CDD:290566	21/58 (36%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	7/23 (30%)
		LRR_8	533..589	CDD:290566	20/61 (33%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	6/25 (24%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
XB5889249	XP_017950848.2	leucine-rich repeat	48..70	CDD:275378	1/3 (33%)
		PLN00113	50..>484	CDD:215061	114/477 (24%)
		LRR_8	70..129	CDD:404697	19/58 (33%)
		leucine-rich repeat	71..94	CDD:275378	9/22 (41%)
		leucine-rich repeat	95..118	CDD:275378	6/22 (27%)
		leucine-rich repeat	119..143	CDD:275378	7/23 (30%)
		LRR	<398..>524	CDD:227223	37/116 (32%)
		leucine-rich repeat	400..423	CDD:275380	8/22 (36%)
		leucine-rich repeat	424..445	CDD:275378	7/23 (30%)
		leucine-rich repeat	446..468	CDD:275378	11/22 (50%)
		leucine-rich repeat	469..491	CDD:275378	5/21 (24%)
		leucine-rich repeat	492..515	CDD:275378	6/18 (33%)
		leucine-rich repeat	516..528	CDD:275378
		LRRCT	524..576	CDD:214507
		TIR	636..777	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910