DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and slitrk5

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002940152.1	Gene:	slitrk5 / 100494014	XenbaseID:	XB-GENE-6034846	Length:	881	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	146/564 - (25%)
Similarity:	236/564 - (41%)	Gaps:	107/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KSLQEYHGSQLSTASTATDVIAGKRTLH---SICERWLQKHCHCTGSLEVLRLSCRGIGILAV-- 173
            |.:|.:....::.|.|:. |::...|:.   .:|:.    .|.|.....:|.::|...||:::
Frog    16 KKMQMWILQTIAFAVTSL-VLSWAETIEYYGEVCDH----SCPCEERDGILTVNCENRGIISLSE 75

  Fly   174 --PVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQN 236
              |...|  |..|.|..|.|.:|..|.|........|.|.:|.|.:::..||.||..||||.|.|
Frog    76 ISPPRFP--VYHLLLFGNLLNRLYLNEFVNYTGASILHLGNNDIQDIETGAFNGLQGLKRLHLNN 138

  Fly   237 CGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTL 301
            ..|:.|...:|.||..|..||::.|.::|::.:....|..|:.|.|..||...:||| |.....|
Frog   139 NKLELLKNDTFIGLQNLEYLQVDYNFIISIEPNTFSRLHSLQVLILNDNLLSTLPTN-LFRFVPL 202

  Fly   302 EALNLGSNLLTIINDEDFP------RMPNLIVLLLKRN------QIMKISAGALKN-LTALKVLE 353
            ..|:|..|.|.::     |      .|..::.|.|:.|      :::     |||: |.::....
Frog   203 THLDLRGNRLKVL-----PYVGLLEHMDKVVELQLEENPWNCSCELI-----ALKDWLYSISYSA 257

  Fly   354 LDDNLISSLPEGL--SKLSQLQELSITSNRLRWIND--TELPRS----MQMLDMRANPLSTISPG 410
            |..:::...|..|  ..|.::.:..:...:|..|.:  .::|||    ........|..:|||..
Frog   258 LVGDVVCETPFRLYGRDLDEISKQELCPRKLISIYEMRPQIPRSTSEYFHTTPASVNSGATISSS 322

  Fly   411 AFRGMSK---LRKLILSDVRTLRSFPELEACHALEI-------------------LKLDRAG--- 450
            .::.::|   .|:...|..||....|.:::.:::.|                   |::...|
Frog   323 VYKNLTKPKSTRQPNRSKGRTTSHRPPIDSGYSISIAYQTKSPVPLECPTNCTCNLQISNLGLNV 387

  Fly   451 ------IQEV------PAN------------LCRQTPRLKS-----LELKTNSLKRIPN--LSSC 484
                  ||.:      |.|            |.|:|..:.|     |.|..|.:..|.:  ....
Frog   388 NCQERKIQSISDLHPKPYNPKKMYLTGNYIALVRRTDFIDSTGLDLLHLGNNRISVIQDRAFGDL 452

  Fly   485 RDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIH 549
            .:||.|.|:.|.|||:..:.|.||:.|..|.|.||.||.:....|..:|.|.||.|..|.:.::.
Frog   453 TNLRRLYLNGNSIEKLTPELFYGLQSLQYLFLQYNSIKEIEPGTFNFVPNLHLLFLNNNLMKHLP 517

  Fly   550 KEAFSGFTALEDLNLGNNIFPELPESG----LRALLHLKTFNNP 589
            ...|||.. |..|||.:|:|..|..||    |::|:.:....||
Frog   518 SNIFSGLN-LSRLNLRSNLFSHLTVSGGLDQLKSLVQIDLHENP 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/24 (21%)
		LRR_RI	180..>383	CDD:238064	60/217 (28%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	23/59 (39%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	11/22 (50%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	15/72 (21%)
		leucine-rich repeat	301..324	CDD:275380	7/28 (25%)
		leucine-rich repeat	325..348	CDD:275380	7/29 (24%)
		LRR_RI	327..567	CDD:238064	73/310 (24%)
		leucine-rich repeat	349..371	CDD:275380	4/23 (17%)
		LRR_8	370..425	CDD:290566	11/63 (17%)
		leucine-rich repeat	372..393	CDD:275380	3/22 (14%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	20/120 (17%)
		leucine-rich repeat	441..464	CDD:275378	10/68 (15%)
		LRR_8	487..545	CDD:290566	25/57 (44%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	20/59 (34%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	10/24 (42%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
slitrk5	XP_002940152.1	leucine-rich repeat	62..79	CDD:275380	3/16 (19%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR	<98..>256	CDD:227223	50/168 (30%)
		leucine-rich repeat	107..130	CDD:275380	8/22 (36%)
		LRR_8	130..189	CDD:338972	21/58 (36%)
		leucine-rich repeat	131..154	CDD:275380	11/22 (50%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..199	CDD:275380	9/20 (45%)
		leucine-rich repeat	202..226	CDD:275380	7/28 (25%)
		leucine-rich repeat	227..430	CDD:275380	37/207 (18%)
		leucine-rich repeat	408..424	CDD:275380	2/15 (13%)
		internalin_A	<429..>561	CDD:380193	45/133 (34%)
		LRR_8	430..489	CDD:338972	20/58 (34%)
		leucine-rich repeat	431..454	CDD:275380	4/22 (18%)
		leucine-rich repeat	455..478	CDD:275380	11/22 (50%)
		leucine-rich repeat	479..497	CDD:275380	7/17 (41%)
		leucine-rich repeat	503..525	CDD:275380	8/21 (38%)
		leucine-rich repeat	526..548	CDD:275380	9/21 (43%)
		LRRCT	559..>595	CDD:214507	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910