DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrrtm1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002935525.1	Gene:	lrrtm1 / 100493874	XenbaseID:	XB-GENE-966481	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	591	Identity:	123/591 - (20%)
Similarity:	210/591 - (35%)	Gaps:	158/591 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPN 204
            ::|.|.|.    |.|.|..    |.|....:..:|.|| :.|:.|.|..|:|::|:...|.....
Frog    35 VNSGCPRL----CRCEGRF----LYCESQNVTEIPHNL-SGVMGLSLRYNSLSELQDGQFTGLIQ 90

  Fly   205 LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGD 269
            |..|.|..|.|..::.|||:.|.::|.|:|.:..:..|...:|:.:..|.|:.|:.|.|.||:.|
Frog    91 LTWLYLDHNHIHTVEGNAFHKLRRVKELTLSSNKITHLANTTFRPMPNLRSVDLSNNNLQSLEAD 155

  Fly   270 CLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQ 334
            ....|:||.||.:..|....:|.......|:|:.|:||.|.|..:....|..:..|..|.|:.|.
Frog   156 LFHGLRKLTTLHMRYNAIKFVPVRIFQDCRSLKFLDLGYNQLKSLARNSFAGLFKLTELHLEHND 220

  Fly   335 IMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDM 399
            ::|::......|.:|..|.:..|.::.:                      :|..:....::.:|:
Frog   221 LVKVNLAHFPRLLSLHSLFMRRNKVTIV----------------------VNSLDFVWKLEKMDL 263

  Fly   400 RANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPR 464
            ..|.:..|.|..|..:                                               |.
Frog   264 SGNEIEYIEPHVFESL-----------------------------------------------PH 281

  Fly   465 LKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYN------RIKA 523
            |:||:|.:|.|..:       |.|:|               |..|.|:.:.|:.|      .:.|
Frog   282 LESLQLDSNRLTYV-------DPRIL---------------NSWKSLSSITLAGNNWDCGRNVCA 324

  Fly   524 LPQ--DAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALE------------DLNLGNNIFPELPE 574
            |..  .||:|       ..:||.:....:.| .|...|:            |....|.|...|..
Frog   325 LASWLSAFKG-------RCDGNMLCTTPEYA-QGEDVLDAVYFFRLCDDPVDPTSANAISTALNN 381

  Fly   575 SGLRALLHLKTFNNPKLREFPPPDT----FPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEA 635
            |...|:      ::|....:...||    ...:||..::..:|             :.|.|:.:.
Frog   382 SDRIAI------DSPTATSYNVQDTEGERTTNVQTATVANEHH-------------ENTVQIHKV 427

  Fly   636 VLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYME 700
            |.......|...:....:...|       |...||:....:..:....:|.|.||..|:|:...:
Frog   428 VTGTMALIFSFLIVVLMLYVSW-------KCFPASLRQLRQCFVTQRRKQKQKQTMHQMASMSAQ 485

  Fly   701 EYFEEH 706
            ||:.::
Frog   486 EYYVDY 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	53/202 (26%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	40/259 (15%)
		leucine-rich repeat	349..371	CDD:275380	3/21 (14%)
		LRR_8	370..425	CDD:290566	6/54 (11%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	7/67 (10%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	14/65 (22%)
		leucine-rich repeat	487..510	CDD:275380	3/22 (14%)
		leucine-rich repeat	511..534	CDD:275380	8/30 (27%)
		LRR_8	533..589	CDD:290566	11/67 (16%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	6/32 (19%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrtm1	XP_002935525.1	LRRNT	38..>61	CDD:214470	7/30 (23%)
		LRR	53..>316	CDD:227223	77/354 (22%)
		leucine-rich repeat	70..90	CDD:275380	6/19 (32%)
		leucine-rich repeat	91..114	CDD:275380	9/22 (41%)
		LRR_8	114..173	CDD:338972	19/58 (33%)
		leucine-rich repeat	115..138	CDD:275380	5/22 (23%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		leucine-rich repeat	187..210	CDD:275380	7/22 (32%)
		leucine-rich repeat	211..234	CDD:275380	6/22 (27%)
		leucine-rich repeat	235..257	CDD:275380	4/43 (9%)
		leucine-rich repeat	258..281	CDD:275380	5/69 (7%)
		leucine-rich repeat	282..300	CDD:275380	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910