DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and opn8

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_004915005.1	Gene:	opn8 / 100493595	XenbaseID:	XB-GENE-983567	Length:	353	Species:	Xenopus tropicalis

Alignment Length:	336	Identity:	84/336 - (25%)
Similarity:	136/336 - (40%)	Gaps:	95/336 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 GVW--VVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFR 821
            ||:  :|.:|::|||..|:...:...|.:..|..|..|||.||..|.|.:..|||..|
Frog    18 GVFLLLVAILTVLGNCAVLATAVKCSSHLKAPDLLSINLAVADLGMAISMYPLAIASA------- 75

  Fly   822 MFAIPWQMSVL-----C---QLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAG 878
                 |..:.|     |   .|.||...:||.:::..:|:|    .|.:|.        |.|.:|
Frog    76 -----WNHAWLGGDASCLYYALMGFFFGVSSMMTLTVMAII----RYRVTS--------SFKYSG 123

  Fly   879 ----------YIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPA---------SLTYVI 924
                      .||.: |::||:.|::||:|...|..    .||.|:...|         ..:::|
Frog   124 CTIEKKAVCILIMCI-WLYALLWAVLPLLGWGRYGP----EPFGTSCTIAWGDFHHSSNGFSFII 183

  Fly   925 SLMFINGCAF---LTLMGCYLKMYWAIR------GSQAWNTNDSRIAKRMALLV----FTDFLCW 976
            |:..:  |..   :|::.||..:.|.:.      .:|....|.:::.|::.||.    |...:.|
Frog   184 SMFIL--CTISPAVTIVVCYSGIAWKLHKAYQEIKNQDKIPNSTKVEKKLTLLAILVSFGFLISW 246

  Fly   977 SPIAFFSITAIFG--------LQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFK------KD 1027
            :|.|..|..::|.        :.|:....||..|.|        ||.:|...:|.|:      |.
Frog   247 TPYAAVSFWSLFHSSKYIPPVVSLLPCLFAKSSTAF--------NPMIYYAFSKTFRRKVKHLKC 303

  Fly  1028 CVTLCKHFEES 1038
            |.....||.:|
Frog   304 CCGWRVHFLQS 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	39/145 (27%)
		7tm_1	770..1017	CDD:278431	71/294 (24%)
opn8	XP_004915005.1	7tmA_Opsin5_neuropsin	17..298	CDD:320202	79/318 (25%)
		TM helix 1	17..41	CDD:320202	8/22 (36%)
		TM helix 2	50..72	CDD:320202	9/21 (43%)
		TM helix 3	88..110	CDD:320202	5/21 (24%)
		TM helix 4	133..149	CDD:320202	6/16 (38%)
		TM helix 5	179..202	CDD:320202	5/24 (21%)
		TM helix 6	232..254	CDD:320202	6/21 (29%)
		TM helix 7	266..291	CDD:320202	8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910