Protein Alignment rk and lrrc8a

DIOPT Version :9

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: XP_002935552.1
• Gene: lrrc8a / 100492279
• XenbaseID: XB-GENE-1012024
• Length: 809
• Species: Xenopus tropicalis
• Alignment Length: 567
• Identity: 132/567 - (23%)
• Similarity: 223/567 - (39%)
• Gaps: 157/567 - (27%)

  Fly    35 DETKENPAPDMQNSQEQEPYVHLQHL--QQQQQQNPQTVQQLSQITVNRTSK---SASVTPTGIR 94
            :|:..:..||::|.     :..:.||  |.....:.:....||:::.|:..:   :...|...:|
 Frog   357 EESSYSDIPDVKND-----FAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNHEWTLDKLR 416

  Fly    95 ENVMLPSADPEKEAQILYEKSLQEYHGSQLS-TASTATDVIAGKRTLHSICERWLQKHCHCTGSL 158
            :.:       .|.:|   ||  .|.|...|| ...|..|::                      .|
 Frog   417 QRI-------TKNSQ---EK--LELHLFMLSGIPDTVFDLV----------------------EL 447

  Fly   159 EVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNL------TKLEANSF-FMAPNLEELTLSDNSII 216
            |||:|.      |...|.:|..:..| .|...|      .|:||.:. |:..||:.|.:....|.
 Frog   448 EVLKLE------LIPDVTIPPSIAQL-TGLKELWLYHTAAKIEAPALAFLRENLKSLHIKFTDIK 505

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .: |...|.|..|:.|.|..                  :|....|..:.:||  |..|::|:.||
 Frog   506 EI-PLWIYSLKNLEELHLTG------------------NLSAENNRYIVIDG--LRELKRLKVLR 549

  Fly   282 LEGNL--FYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALK 344
            |:.||  ..::.|:....|:.|...|.|:.|:.:                   |.:.|     :.
 Frog   550 LKSNLTKLPQVVTDVGVHLQKLSVNNEGTKLMVL-------------------NSLKK-----MV 590

  Fly   345 NLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISP 409
            |||.|:::..|   :..:|..:..|..|||:.:..|.|:.|.:                  .||
 Frog   591 NLTELELVRCD---LERIPHSIFSLHNLQEIDLKDNNLKTIEE------------------IIS- 633

  Fly   410 GAFRGMSKLR--KLILSDVRTLRSFP-ELEACHALEILKLDRAGIQEVPAN--LCRQTPRLKSLE 469
              |:.:.:|.  ||..:.:..:   | ::....:||.|.|:|..|:::|..  |||   :|:.|:
 Frog   634 --FQHLHRLTCLKLWYNHIAYI---PIQIGNLASLERLYLNRNKIEKIPTQLFLCR---KLRHLD 690

  Fly   470 LKTNSLKRI-PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533
            |..|||..| |.:...:.|:.|.:::|.||.:..:.|. .|:|..|.|..|.:::||....: :.
 Frog   691 LSHNSLSSIPPEIGHLQSLQYLAVTANHIENLPAELFL-CKKLRTLNLGNNVLQSLPSRVGE-LT 753

  Fly   534 KLQLLDLEGNEISYI-------HKEAFSGFTALEDLNLGNNIFPELP 573
            .|..::|.||.:.|:       |....||....|||      |..||
 Frog   754 NLSQVELRGNRLEYLPVELGDCHLLKRSGLVVEEDL------FNTLP 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	48/211 (23%)
		leucine-rich repeat	183..204	CDD:275380	7/27 (26%)
		LRR_8	203..263	CDD:290566	12/59 (20%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR_8	252..311	CDD:290566	17/60 (28%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	8/24 (33%)
		LRR_8	299..359	CDD:290566	11/59 (19%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	64/252 (25%)
		leucine-rich repeat	349..371	CDD:275380	4/21 (19%)
		LRR_8	370..425	CDD:290566	12/56 (21%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	22/73 (30%)
		leucine-rich repeat	441..464	CDD:275378	10/24 (42%)
		LRR_8	487..545	CDD:290566	17/57 (30%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	14/48 (29%)
		leucine-rich repeat	535..558	CDD:275380	8/29 (28%)
		leucine-rich repeat	559..580	CDD:275380	6/15 (40%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc8a	XP_002935552.1	Pannexin_like	1..339	CDD:372171
		leucine-rich repeat	425..446	CDD:275380	8/44 (18%)
		PLN00113	<434..>773	CDD:215061	105/444 (24%)
		leucine-rich repeat	447..469	CDD:275380	9/28 (32%)
		leucine-rich repeat	470..493	CDD:275380	5/22 (23%)
		leucine-rich repeat	494..516	CDD:275380	6/22 (27%)
		leucine-rich repeat	517..544	CDD:275380	9/46 (20%)
		leucine-rich repeat	592..614	CDD:275380	6/24 (25%)
		leucine-rich repeat	615..639	CDD:275380	9/44 (20%)
		leucine-rich repeat	640..662	CDD:275380	4/24 (17%)
		leucine-rich repeat	663..685	CDD:275380	10/24 (42%)
		leucine-rich repeat	686..708	CDD:275380	8/21 (38%)
		leucine-rich repeat	709..731	CDD:275380	6/22 (27%)
		leucine-rich repeat	732..754	CDD:275380	6/22 (27%)
		leucine-rich repeat	755..775	CDD:275380	5/19 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910