DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrig1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002938412.1	Gene:	lrig1 / 100491453	XenbaseID:	XB-GENE-494193	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	147/528 - (27%)
Similarity:	232/528 - (43%)	Gaps:	107/528 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|||.|    |.|..:|:.|.|.:||...|.|:|.:|.|.:::..:|...|.|.|:.|..|.:.
Frog    32 CTCTGDL----LDCSNLGLTAPPSDLPAWTVHLNLSSNKLKEIDPAAFAQLPELREVHLGHNELT 92

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:                         |.......|:|:|.|:.|.:.|:|
Frog    93 GI-------------------------PHLGTAAPQVTTLSLHHNKIRSID-------------- 118

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
                      .:.|.....||.|:|.||.||.|....||....:..|.|..|:|..:..|:..:|
Frog   119 ----------PSQLKPYVALETLDLSSNELTEIRSGSFPAGLRIKELHLGSNKISSLEPGSFDSL 173

  Fly   347 T-ALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTIS 408
            : :|..|.|..|.||.||..:.:|.:|.:|.:..||:|.|......  .|:::|.::.|.:|.::
Frog   174 SRSLLTLRLSKNRISQLPVKVFRLPRLTQLELNRNRIRLIEGLTFQGLESLEVLKLQRNNISKLT 238

  Fly   409 PGAFRGMSKLRKLILSDVRTLRSFPE-----LEACHALEILKLDRAGIQEVPA---NLCRQTPRL 465
            .|||.|:|:::.|.|.:    .|..|     |....:|:.|.|....|..:.:   :.|:   :|
Frog   239 DGAFWGLSRMQILHLEN----NSLTEVNSGSLYGLLSLQQLHLSHNSISTISSAGWSFCQ---KL 296

  Fly   466 KSLELKTNSLKRIPNLSSCRDLRLLD---LSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQD 527
            :.|.|..|:|.|:.. .|..||.:||   ||.|.|..|....|.|||.|..|.|.:|.|....:|
Frog   297 QELVLSHNNLTRLDE-GSLADLGVLDVLRLSYNSISHIAEGAFKGLKSLRILELDHNEISGTIED 360

  Fly   528 ---AFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNP 589
               ||.|:..|..|.|.||:|..:.|.||||..:||.||||        |:.||: :|.:.|...
Frog   361 TNGAFIGLESLNKLTLFGNKIKSVAKRAFSGIESLEHLNLG--------ENALRS-VHSEAFGEM 416

  Fly   590 K-LREFPPPDTFPRIQTLILSYAYHCCAFLPLVA--MSSQKKTSQVQEAVLFPSDAEFDMTLWNN 651
            | |:|.           ::.|.::.|...|..:.  ::|::..::|:.:...|.      :|.|.
Frog   417 KNLKEL-----------VVGSSSFLCDCHLKWLPQWLTSRRLQTKVKASCAHPG------SLNNT 464

  Fly   652 SMMNIWPQ 659
            |:.::.|:
Frog   465 SIFSVPPR 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	50/203 (25%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	11/59 (19%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	1/22 (5%)
		LRR_8	252..311	CDD:290566	14/58 (24%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		LRR_8	299..359	CDD:290566	21/60 (35%)
		leucine-rich repeat	301..324	CDD:275380	11/22 (50%)
		leucine-rich repeat	325..348	CDD:275380	6/23 (26%)
		LRR_RI	327..567	CDD:238064	86/256 (34%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	17/56 (30%)
		leucine-rich repeat	372..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	17/75 (23%)
		leucine-rich repeat	441..464	CDD:275378	5/25 (20%)
		LRR_8	487..545	CDD:290566	26/63 (41%)
		leucine-rich repeat	487..510	CDD:275380	11/25 (44%)
		leucine-rich repeat	511..534	CDD:275380	9/25 (36%)
		LRR_8	533..589	CDD:290566	22/55 (40%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	9/20 (45%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrig1	XP_002938412.1	LRRNT	28..59	CDD:214470	12/30 (40%)
		leucine-rich repeat	57..80	CDD:275378	6/22 (27%)
		PLN00113	<58..>370	CDD:215061	100/368 (27%)
		leucine-rich repeat	104..127	CDD:275380	7/46 (15%)
		leucine-rich repeat	128..151	CDD:275380	11/22 (50%)
		leucine-rich repeat	152..199	CDD:275380	15/46 (33%)
		leucine-rich repeat	200..223	CDD:275380	6/22 (27%)
		leucine-rich repeat	224..247	CDD:275380	7/22 (32%)
		leucine-rich repeat	248..295	CDD:275380	10/53 (19%)
		leucine-rich repeat	272..292	CDD:275380	4/19 (21%)
		leucine-rich repeat	296..319	CDD:275380	9/23 (39%)
		leucine-rich repeat	320..343	CDD:275380	10/22 (45%)
		LRR_8	343..405	CDD:338972	27/69 (39%)
		leucine-rich repeat	344..370	CDD:275380	9/25 (36%)
		leucine-rich repeat	371..394	CDD:275380	11/22 (50%)
		leucine-rich repeat	395..413	CDD:275380	10/26 (38%)
		LRRCT	429..477	CDD:214507	9/50 (18%)
		leucine-rich repeat	445..471	CDD:275380	5/31 (16%)
		IG	488..582	CDD:214652
		Ig_1	603..677	CDD:143240
		I-set	680..759	CDD:369462
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910