Protein Alignment rk and lrrc8e.2

DIOPT Version :9

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: XP_002935462.1
• Gene: lrrc8e.2 / 100490082
• XenbaseID: XB-GENE-22064203
• Length: 779
• Species: Xenopus tropicalis
• Alignment Length: 481
• Identity: 114/481 - (23%)
• Similarity: 190/481 - (39%)
• Gaps: 127/481 - (26%)

  Fly    60 LQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRE--NVMLPSADPE-----KEAQILYEKSLQ 117
            |::.:..:..|:::|.:.....|        .|.||  ..||| |.|:     .|.::|   .|:
 Frog   375 LREMELNSEWTMEKLGEFVTKDT--------RGRRELQLSMLP-AIPKAVYNLTEVEVL---KLE 427

  Fly   118 EYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVV 182
            ....:::|.|.:....:.....:|  |...:....:|.                     |.|::.
 Frog   428 LIASARISGAVSRLSALTELHLIH--CSTKMDTDAYCF---------------------LQNKLK 469

  Fly   183 VLDLGNNNLTKLEANSFFMAPNLEELTL------SDNSIINMDPNAFYGLAKLKRLSLQNCGLKS 241
            ||.:...:|.::.. ..:...:|:||.|      |:|..|.:  |:..||..|:.||| |..::.
 Frog   470 VLHIRFTDLEEIPP-WIYNLKSLQELHLSGNLNSSNNKSIRL--NSLRGLTHLRALSL-NSNVQH 530

  Fly   242 LPPQSFQGLAQLTSLQLNGNALVSLDGDC-LGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALN 305
            ||........||:.|.:. |...:|||.. |..:::|..:.|:.....:|| ..|:.|.:|:.::
 Frog   531 LPSAILDVAGQLSKLSIQ-NGGTTLDGQTQLKRMKQLLEVELQDCQISKIP-GVLSSLLSLQCID 593

  Fly   306 LGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLS 370
            |.||||.::|:                       .|..:.|..|.:|.|:.|.|..||..:..|.
 Frog   594 LSSNLLNVVNE-----------------------IGTFQRLRGLTILRLNHNAIGCLPPSIQHLH 635

  Fly   371 QLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFP-E 434
            .|:||||:.|||..|                 |.|..|      :.:||.:.:|. ..::..| |
 Frog   636 NLEELSISHNRLETI-----------------PTSLFS------LVRLRNVDISH-NNIKVIPLE 676

  Fly   435 LEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEK 499
            :.....||...:....|..:|..|||.| ||:||:...|:|..:|.:
 Frog   677 VGQLSRLEWFAVTGNQISSLPHELCRCT-RLRSLKAGFNNLSSLPTV------------------ 722

  Fly   500 IQGKPFNGLKQLNDLLLSYNRIKALP 525
                 ||.|..|:.|.|:.|.:.:||
 Frog   723 -----FNKLTLLSTLELAGNHLISLP 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	1/20 (5%)
		LRR_RI	180..>383	CDD:238064	58/209 (28%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	21/65 (32%)
		leucine-rich repeat	205..228	CDD:275380	10/28 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	18/59 (31%)
		leucine-rich repeat	253..276	CDD:275380	7/23 (30%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	13/59 (22%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	51/200 (26%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	14/54 (26%)
		leucine-rich repeat	372..393	CDD:275380	9/20 (45%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	20/68 (29%)
		leucine-rich repeat	441..464	CDD:275378	8/22 (36%)
		LRR_8	487..545	CDD:290566	9/39 (23%)
		leucine-rich repeat	487..510	CDD:275380	3/22 (14%)
		leucine-rich repeat	511..534	CDD:275380	6/15 (40%)
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc8e.2	XP_002935462.1	Pannexin_like	1..313	CDD:372171
		leucine-rich repeat	444..466	CDD:275380	4/44 (9%)
		LRR_8	467..527	CDD:338972	18/63 (29%)
		leucine-rich repeat	468..490	CDD:275380	3/22 (14%)
		leucine-rich repeat	491..518	CDD:275380	10/28 (36%)
		LRR	502..>776	CDD:227223	85/318 (27%)
		leucine-rich repeat	519..541	CDD:275380	7/22 (32%)
		leucine-rich repeat	542..565	CDD:275380	7/23 (30%)
		leucine-rich repeat	566..588	CDD:275380	6/22 (27%)
		leucine-rich repeat	589..613	CDD:275380	9/46 (20%)
		leucine-rich repeat	614..636	CDD:275380	8/21 (38%)
		leucine-rich repeat	637..659	CDD:275380	12/44 (27%)
		leucine-rich repeat	660..682	CDD:275380	5/22 (23%)
		leucine-rich repeat	706..728	CDD:275380	9/44 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910