DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and tlr2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002933537.2	Gene:	tlr2 / 100485771	XenbaseID:	XB-GENE-481145	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	132/597 - (22%)
Similarity:	220/597 - (36%)	Gaps:	163/597 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |||:           .:...|:|..||.:|..|:|.:|.:..:..........|:.|.|..|:|.
Frog    34 CHCS-----------SMHWEAIPSGLPRDVRGLNLSSNAIQIVTETDLQPYDQLQTLLLQYNAIH 87

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCL-GHLQKLRTL 280
            .::..:|..|..|:.|.|....|..|....|:.|..|..|.|.||..::|..:.| ..|..||:|
Frog    88 TINDGSFQPLGNLEELDLSYNNLSHLSSAWFRNLYNLKHLNLLGNQYLTLGNNSLFASLSSLRSL 152

  Fly   281 RLEGN----LFYRIPTNALAGLRTLE--ALNLG----------------------SNLLTIINDE 317
            :. ||    ...::...:|..|..||  |..||                      .||..::||
Frog   153 QF-GNQDFSAIQKLHFESLERLNILEIKAAQLGLYEEGSLAAIKQINHAVLTVNIQNLRALLND- 215

  Fly   318 DFPRMPNLIVLLLKRNQI---MKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQL------- 372
               .:.::.:|.:|..|.   ..:.|..:.|.|::|.|...:.:|:.  :..|:|.::
Frog   216 ---FIHSVTLLEMKDMQFGDAADVKAMVILNDTSIKYLVFRNCIITD--QSASRLLEIFQTYRNI 275

  Fly   373 ----------------------QELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGM 415
                                  ...|:|:   ..||...:|:.....|::         |.::..
Frog   276 TDFILDDSTLYGTGTASPVIGDDPFSVTT---AIINKLHIPKFFLFSDLQ---------GIYKLA 328

  Fly   416 SKLRKLILSDVRTL-------RSFPELEACHALEILKLDRAGIQEVPANLCRQT----------P 463
            |..:.:...|.:..       |||..|:        .||.:| ..:..||...:          |
Frog   329 SNFKNIACIDSKVFLMPCAFSRSFSSLQ--------YLDLSG-NLLSDNLLASSACAFEGGGAWP 384

  Fly   464 RLKSLELKTN---SLKRIPNLSS-CRDLRLLDLSSNQIEKIQGKPF---NGLKQLNDLLLSYNRI 521
            .|::|.:..|   ||:|:..::| .:.|..||:|.|...::.....   ..||.||......:.|
Frog   385 ILQTLNVSRNLLTSLRRLAQITSGLKYLTNLDVSQNNFGELSTSTCQWPKSLKYLNISSSQMSNI 449

  Fly   522 KALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTA----LEDLNLGNNIFPELPESGLRALLH 582
            ..:|       |.||:||:..|.::.        ||.    |.:|.:.||...:|||......|.
Frog   450 TCIP-------PTLQILDVSSNYLTV--------FTIKMPNLTELYISNNRLSKLPEGMYFPRLF 499

  Fly   583 LKTFNNPKLREF--PPPDTFPRIQTLI-LSYAYHC-CAFLPL-----VAM-----------SSQK 627
            :.:.:..||.:|  ...|.||::.||. ....|.| |.||..     :|:           .|..
Frog   500 MLSIDRNKLNDFYQSDLDLFPQLTTLDGRDNNYLCSCQFLSFMHSHTIALVGWPDDYICDSPSSV 564

  Fly   628 KTSQVQEAVLFP 639
            :..::|:|.|.|
Frog   565 RGKRIQDANLPP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	55/263 (21%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	21/87 (24%)
		leucine-rich repeat	253..276	CDD:275380	8/23 (35%)
		leucine-rich repeat	277..300	CDD:275380	7/26 (27%)
		LRR_8	299..359	CDD:290566	17/86 (20%)
		leucine-rich repeat	301..324	CDD:275380	9/46 (20%)
		leucine-rich repeat	325..348	CDD:275380	5/25 (20%)
		LRR_RI	327..567	CDD:238064	58/299 (19%)
		leucine-rich repeat	349..371	CDD:275380	5/21 (24%)
		LRR_8	370..425	CDD:290566	8/83 (10%)
		leucine-rich repeat	372..393	CDD:275380	5/49 (10%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	18/88 (20%)
		leucine-rich repeat	441..464	CDD:275378	5/32 (16%)
		LRR_8	487..545	CDD:290566	17/60 (28%)
		leucine-rich repeat	487..510	CDD:275380	6/25 (24%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		LRR_8	533..589	CDD:290566	16/59 (27%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
tlr2	XP_002933537.2	internalin_A	55..>247	CDD:380193	47/196 (24%)
		leucine-rich repeat	55..75	CDD:275378	3/19 (16%)
		LRR_8	75..133	CDD:404697	18/57 (32%)
		leucine-rich repeat	76..99	CDD:275378	7/22 (32%)
		leucine-rich repeat	100..123	CDD:275378	7/22 (32%)
		leucine-rich repeat	124..148	CDD:275378	8/23 (35%)
		leucine-rich repeat	149..162	CDD:275378	5/13 (38%)
		leucine-rich repeat	322..352	CDD:275378	4/38 (11%)
		PRK15370	<353..>508	CDD:185268	41/178 (23%)
		leucine-rich repeat	355..382	CDD:275380	6/35 (17%)
		leucine-rich repeat	386..411	CDD:275380	7/24 (29%)
		leucine-rich repeat	412..435	CDD:275380	5/22 (23%)
		leucine-rich repeat	436..455	CDD:275380	6/25 (24%)
		leucine-rich repeat	456..475	CDD:275380	7/26 (27%)
		leucine-rich repeat	476..497	CDD:275380	7/20 (35%)
		leucine-rich repeat	498..521	CDD:275380	6/22 (27%)
		TIR	634..779	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910