DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and mtnr1c

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_031747846.1	Gene:	mtnr1c / 100485432	XenbaseID:	XB-GENE-985295	Length:	429	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	96/413 - (23%)
Similarity:	165/413 - (39%)	Gaps:	97/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   682 NEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLP 746
            |...|..:|.|.|.|.                              :|.|.|:.|.|
Frog     5 NSTCLDCRTAGTIGTE------------------------------QDAQDGASQGL-------- 31

  Fly   747 CADLFDWWTLRCGVWVVF--LLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIY---L 806
                    |....|.::|  ::.:|||..|:..:|.::...:.....|.:|:.||..:.:|   :
Frog    32 --------TSALAVVLIFTIIVDVLGNMLVILSVLRNKKLQNAGNLFVVSLSVADLVVAVYPYPV 88

  Fly   807 GILAIVDAATLGEFRMFAIPWQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNK 870
            .::||           |...|.: ::.||:||||..||...||:.:..|.:.|...|.|::..:|
Frog    89 ILIAI-----------FQNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDK 142

  Fly   871 RLSLKQAGYIMSVGWVFALIMALMP--LVGVSDY--RKFAVCLPFETTTGPASLTYVISLMFING 931
            ..:.|.....:.:.|:..:| |::|  .||...|  |.|: |...:|.:...::|.|: :.||..
Frog   143 LFNQKSTWCYLGLTWILTII-AIVPNFFVGSLQYDPRIFS-CTFAQTVSSSYTITVVV-VHFIVP 204

  Fly   932 CAFLTLMGCYLKMYWAI----------RGSQAWNTNDSRIAKRMALLVFTDF-LCWSPIAFFSI- 984
            .:.:|.  |||:: |.:          ...|.....|.|....| .:||..| :||:|:.|..:
Frog   205 LSVVTF--CYLRI-WVLVIQVKHRVRHDFKQKLTPTDLRNFLTM-FVVFVLFAVCWAPLNFIGLA 265

  Fly   985 TAIFGLQLISLEQAKIFTV--FVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVV-----G 1042
            .||..|.:.......:|.|  |:...|||.|..:|.::.:.|:|:...:.......|::     .
Frog   266 VAINPLHVAPKIPEWLFVVSYFMAYFNSCLNAVIYGLLNQNFRKEYKRILMSLLTPRLLFLDTSR 330

  Fly  1043 GGGPGGRG----AVARTKRGDLP 1061
            ||..|.:.    ||....:.|:|
Frog   331 GGTEGMKSKPSPAVTNNNQADMP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	33/133 (25%)
		7tm_1	770..1017	CDD:278431	70/268 (26%)
mtnr1c	XP_031747846.1	7tm_GPCRs	33..311	CDD:421689	76/295 (26%)
		TM helix 1	34..60	CDD:410628	7/25 (28%)
		TM helix 2	67..92	CDD:410628	5/24 (21%)
		TM helix 3	105..135	CDD:410628	12/29 (41%)
		TM helix 4	147..169	CDD:410628	5/22 (23%)
		TM helix 5	189..218	CDD:410628	9/32 (28%)
		TM helix 6	236..266	CDD:410628	10/30 (33%)
		TM helix 7	279..304	CDD:410628	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910