DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrrtm4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_031755133.1	Gene:	lrrtm4 / 100485215	XenbaseID:	XB-GENE-949702	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	646	Identity:	135/646 - (20%)
Similarity:	223/646 - (34%)	Gaps:	194/646 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNS 214
            |:|.|.|.:    :.|.......:|.|:......|.|..|::..|:::.|.....|..|.|..|.
Frog    36 KNCRCDGKI----VYCESHAFRDIPQNISGGSQGLSLRYNSIKMLKSHQFSGLNQLVWLYLDHNY 96

  Fly   215 IINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRT 279
            |..:|.:||.|:.:||.|.|.:..:..|...:|..:..|.:|.|:.|.|.:|..:....|:||..
Frog    97 ISTVDEDAFQGIRRLKELILSSNKISYLGNSTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLLI 161

  Fly   280 LRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALK 344
            |.|..|....:|.......|.|:.|:||.|.|..::...|..:..|..|.|:.||..|::.....
Frog   162 LHLRSNSLKTVPVRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKVNFAHFP 226

  Fly   345 NLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISP 409
            .|..|:.|.|..|.|.|:.:||:              ..|       .::|.||:..|.:..:.|
Frog   227 RLFNLRSLYLQWNKIRSISQGLT--------------WTW-------SALQNLDLSGNDIQNLEP 270

  Fly   410 GAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
            |.|:.:                                               |.|:.|.|.:|.
Frog   271 GTFQCL-----------------------------------------------PNLQKLNLDSNK 288

  Fly   475 LKRI--PNLSSCRDLRLLDLSSNQIEKIQG--------KPFNGLKQLNDLLLSYNRIKALPQDAF 529
            |..:  ..|::...|..:.||.|..|..:.        |.|.|.|:...:..|
Frog   289 LTNVTQETLNAWISLTSITLSGNIWECTKKICPLVFWLKNFKGNKESIMICAS------------ 341

  Fly   530 QGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREF 594
               ||    :::|.:::          .|:|..|:.|.. |.|...  ||   ..|...|...:|
Frog   342 ---PK----NMQGEKVT----------DAVETYNICNET-PVLATE--RA---YPTTKPPPKPQF 383

  Fly   595 PPPDTF----------------PRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAE 643
            .|..|.                |.:||.:....|...:|..::|.|          ..||.|.|.
Frog   384 TPKPTIYKLESVSSTPYTSSPSPALQTPMAEQEYEHVSFHKIIAGS----------VALFLSVAM 438

  Fly   644 FDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDV 708
            ..:.::.:     |       |:..|||....::::.....:...::..|| .|.::||:
Frog   439 ILLVIYVS-----W-------KRYPASMKQLQQSSMMKRRRKKARESERQI-NSPLQEYY----- 485

  Fly   709 SGPATGYGFGTGLFSGMSTEDFQPGSVQCLPM----PGPFLPCADLFD-------WWTLRC 758
                               .|::|.:.:.:.:    .|   |||....       .|:|||
Frog   486 -------------------VDYKPSNTESMDVLVNGSG---PCAYTISGSRECELCWSLRC 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	56/202 (28%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	45/249 (18%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	7/69 (10%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	13/65 (20%)
		leucine-rich repeat	487..510	CDD:275380	8/30 (27%)
		leucine-rich repeat	511..534	CDD:275380	1/22 (5%)
		LRR_8	533..589	CDD:290566	12/55 (22%)
		leucine-rich repeat	535..558	CDD:275380	1/22 (5%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrtm4	XP_031755133.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910