DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and LOC100331807

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_009293718.2	Gene:	LOC100331807 / 100331807	-ID:	-	Length:	455	Species:	Danio rerio

Alignment Length:	367	Identity:	88/367 - (23%)
Similarity:	142/367 - (38%)	Gaps:	91/367 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   728 EDFQ-PGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVP-RF 790
            :||. |..:....:|...||...|.        ..::|.|:::|||.|: |:||.|..::.| .|
Zfish    24 QDFSIPPLISIPRLPSSLLPVFGLL--------YVLIFGLAVVGNGAVL-VILCRRKALESPSTF 79

  Fly   791 LVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQM-SVLCQLSGFLAVLSSELSVYTLAVI 854
            .:|:||.:|..:.|      :...|||  .:.|...|.. ..||:|..||.|.:...|:.|:..|
Zfish    80 FICSLALSDLLISI------VCVPATL--LQHFFTNWLAGDFLCKLIPFLQVTAISTSMLTMTCI 136

  Fly   855 TLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVS------DY----------- 902
            .:||...|.:.:|:.....|..|..::...|:.||.:| .|:..|.      |:
Zfish   137 AVERFQGILYPLHVRNSYFLCHAFKMLVTVWIVALAIA-APMWFVQKVEVKYDFLFDVHHTCCLE 200

  Fly   903 --------RKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTND- 958
                    |.:..||              ..|:|:...|.:.:      :||.|. .:.|..:.
Zfish   201 VWPNQQQRRVYTTCL--------------CVLVFLAPLATMAI------LYWKIM-RELWGNHKV 244

  Fly   959 -------------SRIAKR-------MALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTV 1003
                         ::|.:|       ||.:|.....||:|....|:...:|...:.|:...:...
Zfish   245 HDIMFQTLPGSEINKITRRKKRAIRMMATVVLLFAACWAPFHLVSLLLDYGQLNLDLDDEFLLVS 309

  Fly  1004 FVLPL---NSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVG 1042
            .|..|   ||.|||.:||.:...||:|.:.|......||..|
Zfish   310 VVQILGFSNSVCNPLIYAALNTTFKRDLLALLTRGWRSRTRG 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	40/129 (31%)
		7tm_1	770..1017	CDD:278431	70/297 (24%)
LOC100331807	XP_009293718.2	7tm_GPCRs	44..336	CDD:333717	77/330 (23%)
		TM helix 1	45..69	CDD:320095	9/32 (28%)
		TM helix 2	78..100	CDD:320095	7/27 (26%)
		TM helix 3	116..138	CDD:320095	7/21 (33%)
		TM helix 4	161..177	CDD:320095	4/16 (25%)
		TM helix 5	209..232	CDD:320095	6/42 (14%)
		TM helix 6	265..290	CDD:320095	6/24 (25%)
		TM helix 7	306..330	CDD:320095	9/23 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910