DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lgr6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017209265.2	Gene:	lgr6 / 100330212	-ID:	-	Length:	962	Species:	Danio rerio

Alignment Length:	909	Identity:	271/909 - (29%)
Similarity:	434/909 - (47%)	Gaps:	120/909 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.....:|.:.|...|:.:||.:|......|||..||:::::.|:|.....|.||.||.|.:.
Zfish    33 CQCEEDGILLLVDCSEQGLSSVPTDLSPLTSYLDLSMNNISEIQPNAFRNLHFLSELRLSGNHLR 97

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            ::......||..||.|.|||..|:.||.:....|..|.||:|:.|.::.:....|..::.||.|.
Zfish    98 HIPGPMLQGLYNLKVLMLQNNQLERLPSEDPWELPNLLSLRLDANLIMEVPARTLSGMRSLRHLW 162

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|....||.:||..|.:|:|:.|..|.:|:|.|..|..:.||:||.|..|.|..:.....:.|
Zfish   163 LDDNALTEIPVSALNDLSSLQAMTLALNRITLIPDYAFRNLSNLVVLHLHNNMIRTLGQNCFEGL 227

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRS--MQMLDMRANPLSTISP 409
            .:|:.|||:.|.:...|..:..|::||||...:|.::.|.:.....:  :|.:....||:..:..
Zfish   228 HSLETLELNFNDLQEFPVAIRTLAKLQELGFHNNNIKAIPERAFVGNPLLQTIHFYENPIQFVGR 292

  Fly   410 GAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
            .||:.:.||..|.|:....:|.||:|:...:|::|.|.|||:..:|.:||...|:||.|||..|.
Zfish   293 SAFQFLPKLHTLSLNGATEIREFPDLKGTTSLQVLTLTRAGLTSLPYDLCHLLPKLKVLELSHNV 357

  Fly   475 LKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLD 539
            ::.:|:...|..|:.:.|..|.|::|:...|..|..|..|.||:|.|.::..|||..:..|..||
Zfish   358 IEELPSFYHCTSLQEIGLQHNLIKQIEMNTFQQLGSLRSLDLSWNSINSIHPDAFFSLQSLIKLD 422

  Fly   540 LEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKL-REFPPPDTFPRI 603
            |.||.:|                        .||.:||.:|.|||...|..| |.|...| ||.|
Zfish   423 LTGNRLS------------------------NLPMTGLTSLTHLKLKGNMALSRSFGLED-FPNI 462

  Fly   604 QTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAV-------------LFP--SDAEFDMTLWNNSM 653
            :.:.:.|||.||.|   ...||.:..||.:|.:             |||  :|..:|:.|
Zfish   463 RVIEMPYAYQCCVF---GGCSSYRSASQWEEQMGSEEEDFQKKSPSLFPIHTDNNYDLDL----- 519

  Fly   654 MNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFG 718
                               :.::.||  .|.:|||
Zfish   520 -------------------EEFQLAI--EESKLQT------------------------------ 533

  Fly   719 TGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRS 783
                           |:||.|:||||.||.:|||.|.:|.|:|::.|:||:||..::..:..|.|
Zfish   534 ---------------SIQCTPIPGPFKPCDNLFDSWVVRLGMWLISLVSLMGNSLLILTVFTSPS 583

  Fly   784 KMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSV 848
            .:...:|::..::.|:...|:..|.||:|||.|.|||.:....|:|...|:..|||:||:||.|:
Zfish   584 YLSPVKFIIGTISGANLLTGLCTGTLALVDARTFGEFALHGAQWEMGAGCRAVGFLSVLASEGSI 648

  Fly   849 YTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFET 913
            ..|.:..::.:.:::.|....|..||.............:|.:|.:||:||.:|....:|:|...
Zfish   649 LFLTLAAVQCSVSVSCARAYGKSPSLGSVRAAAVACLALSLAVAALPLIGVGEYGATPLCMPSPL 713

  Fly   914 TTG-PASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWS 977
            ..| |::|.::::|:.:|...||.:.|.|:|:||.:......:..|..:.|.:|.|:||:.|.:.
Zfish   714 PDGEPSTLGFMVALIMMNSLCFLVITGTYIKLYWDLMKGDFDSIWDCAMIKHVAWLIFTNCLLYC 778

  Fly   978 PIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCK--HFEESR 1039
            |:||.:.:::..|..:|.|..|...:.:|||.:..||.||.:....|::|...|..  |....|
Zfish   779 PVAFLTFSSLLSLFPVSEEVVKSVVLVLLPLPASINPLLYLLFNPHFREDMRLLLSRAHLNHDR 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	69/202 (34%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	23/59 (39%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	73/241 (30%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	15/56 (27%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	25/67 (37%)
		leucine-rich repeat	441..464	CDD:275378	9/22 (41%)
		LRR_8	487..545	CDD:290566	22/57 (39%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	15/55 (27%)
		leucine-rich repeat	535..558	CDD:275380	7/22 (32%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433	37/127 (29%)
		7tm_1	770..1017	CDD:278431	73/247 (30%)
lgr6	XP_017209265.2	LRRNT	28..64	CDD:214470	8/30 (27%)
		PLN00113	53..>448	CDD:331614	135/418 (32%)
		leucine-rich repeat	62..85	CDD:275380	7/22 (32%)
		leucine-rich repeat	86..109	CDD:275380	8/22 (36%)
		leucine-rich repeat	110..133	CDD:275380	10/22 (45%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		leucine-rich repeat	158..181	CDD:275380	10/22 (45%)
		leucine-rich repeat	182..205	CDD:275380	8/22 (36%)
		leucine-rich repeat	206..229	CDD:275380	7/22 (32%)
		leucine-rich repeat	230..252	CDD:275380	7/21 (33%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..298	CDD:275380	5/20 (25%)
		leucine-rich repeat	324..338	CDD:275378	6/13 (46%)
		leucine-rich repeat	348..369	CDD:275380	8/20 (40%)
		leucine-rich repeat	370..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..417	CDD:275380	9/22 (41%)
		leucine-rich repeat	418..438	CDD:275380	11/43 (26%)
		7tmA_LGR6	554..829	CDD:320484	83/274 (30%)
		TM helix 1	555..581	CDD:320484	8/25 (32%)
		TM helix 2	588..613	CDD:320484	6/24 (25%)
		TM helix 3	633..663	CDD:320484	10/29 (34%)
		TM helix 4	675..697	CDD:320484	3/21 (14%)
		TM helix 5	719..748	CDD:320484	9/28 (32%)
		TM helix 6	757..787	CDD:320484	10/29 (34%)
		TM helix 7	797..822	CDD:320484	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1997
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26229
orthoMCL	1	0.900	-	-		OOG6_106088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.870