DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lgr4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001119970.1	Gene:	lgr4 / 100144922	XenbaseID:	XB-GENE-5959108	Length:	955	Species:	Xenopus tropicalis

Alignment Length:	989	Identity:	290/989 - (29%)
Similarity:	441/989 - (44%)	Gaps:	176/989 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |...|..:     |.|.|::.||..|......|||..||:|||...:|...|.||||.|:.|.:.
Frog    37 CDLDGGAD-----CSGKGLVTVPDGLSVFTHSLDLSMNNITKLPEGAFKGFPYLEELRLAGNDLS 96

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:.|.|..||.:||.|:|||..||::|.:|.:||..|.||:|:.|.:|::..|....|.:||.|.
Frog    97 IIHPMALSGLKELKVLTLQNNQLKTVPSESLKGLVSLQSLRLDANHIVTVPEDSFEGLVQLRHLW 161

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|....:|...|:.|.:|:||.|..|.::.|.|..|..:.:|:||.|..|:|..:.......|
Frog   162 LDDNSLTEVPIRPLSNLPSLQALTLALNKISHIPDYAFSNLSSLVVLHLHNNKIRTLGPHCFHGL 226

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND-----TELPRSMQMLDMRANPLST 406
            ..|:.|:|:.|.:...|:.:..|..|:||...||.:..|.|     ..|.|::.:.|   ||||.
Frog   227 DNLEALDLNYNNLIDFPDSIRSLPNLKELGFHSNSITIIPDGAFVKNPLLRTIHLYD---NPLSF 288

  Fly   407 ISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471
            :...||:.:|.|..||:.....::.||.|...:.||.|.|....|:.:|...|::.
Frog   289 VGNSAFQNLSDLHFLIIRGASNVQWFPNLTGTNNLESLTLTGTKIRSIPIKFCQEQ--------- 344

  Fly   472 TNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536
                         :.||.||||.|:|..:.|  |.|...|.::.|..|:|:.:..:.|||:..|:
Frog   345 -------------KMLRTLDLSYNEISALVG--FEGCSSLEEVYLQNNQIQEVQNETFQGLAALR 394

  Fly   537 LLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFP 601
            :|||..|.|..||||||....||.:|:|..|.....|.:||..|..||...||..:|........
Frog   395 MLDLSRNRIHTIHKEAFVTLKALTNLDLSFNDLTAFPTAGLHGLNQLKLTGNPNFKETLTAKDLI 459

  Fly   602 RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQ 666
            ::.::.:.|||.||||...                              ||.|.
Frog   460 KLSSVSVPYAYQCCAFSAC------------------------------NSYMT----------- 483

  Fly   667 LGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ 731
                      |.:  .|::|:.|           ....:||.:.....|         |.|||.:
Frog   484 ----------TTV--EEDRLRAQ-----------RLLLDHDRAAMDPDY---------MGTEDDK 516

  Fly   732 ---PGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVC 793
               ...:||.|..|||.||..|...|.:|..||.:|||:|:.|..|:..:..|.|::...:..:.
Frog   517 EHVQALIQCNPATGPFKPCEYLLGSWMIRLTVWFIFLLALIFNVIVIVTMFASCSQLTSSKLFIG 581

  Fly   794 NLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLER 858
            .:|.::.|||:|.|.|.::|..:.|:|..|.|.|:....|:::||||:.|||.:::.|.:..:||
Frog   582 LIAVSNLFMGVYTGTLTVLDTISWGQFAEFGIWWETGNGCKVAGFLAIFSSESAIFFLMLAAIER 646

  Fly   859 NYAITHAIHLNKRLSLK--QAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLT 921
            :.:....|...|...|:  |...:::|  :.|.....:||..:.::....:||||.|...| ||.
Frog   647 SLSAKDIIKKEKHQHLRKFQVASLLAV--LLAAAAGCLPLFHIGEFSSSPLCLPFPTGETP-SLG 708

  Fly   922 YVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFS--- 983
            :.::|:.:|..|||.::..|.|:|..|.........:|.:.|.:|.|:||:.:.:.|:||||
Frog   709 FTVTLVLLNSLAFLIMVITYTKLYCTIEKEDLSENAESSMIKHVAWLIFTNCIFFCPVAFFSFAP 773

  Fly   984 -ITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKD-------------------- 1027
             ||||:    ||.|..|..|:..|||.:|.||.||.....:||:|
Frog   774 LITAIY----ISPEIMKSVTLIFLPLPACLNPVLYVFFNPKFKEDWKLLRWRLTKRSGSVAVATN 834

  Fly  1028 ----CVT--------LCKHFEESRVVGGGGPGGRGAVARTKRGDL---PPPLLPAAAVAHPPGCR 1077
                |||        :..|.:          ||..||.......|   ||   |...:.....|.
Frog   835 SQRGCVTQDFYYDFGMYSHLQ----------GGNFAVCDYCESVLLKNPP---PCKHLIKSHSCP 886

  Fly  1078 CLRMLPSEMPN--W 1089
            .|.::|.:.|:  |
Frog   887 TLAVVPCQRPDNYW 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	74/202 (37%)
		leucine-rich repeat	183..204	CDD:275380	9/20 (45%)
		LRR_8	203..263	CDD:290566	28/59 (47%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	12/22 (55%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	76/244 (31%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	20/59 (34%)
		leucine-rich repeat	372..393	CDD:275380	8/25 (32%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	13/67 (19%)
		leucine-rich repeat	441..464	CDD:275378	7/22 (32%)
		LRR_8	487..545	CDD:290566	23/57 (40%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	23/55 (42%)
		leucine-rich repeat	535..558	CDD:275380	12/22 (55%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433	38/129 (29%)
		7tm_1	770..1017	CDD:278431	79/252 (31%)
lgr4	NP_001119970.1	LRR 1	57..81		10/23 (43%)
		leucine-rich repeat	61..84	CDD:275380	9/22 (41%)
		LRR_8	62..119	CDD:290566	26/56 (46%)
		LRR 2	83..105		9/21 (43%)
		LRR_RI	85..371	CDD:238064	101/312 (32%)
		leucine-rich repeat	85..108	CDD:275380	10/22 (45%)
		LRR 3	106..129		11/22 (50%)
		LRR_8	107..167	CDD:290566	25/59 (42%)
		leucine-rich repeat	109..132	CDD:275380	12/22 (55%)
		LRR 4	131..153		7/21 (33%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR 5	155..177		7/21 (33%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		LRR 6	178..201		9/22 (41%)
		LRR_8	179..239	CDD:290566	19/59 (32%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR 7	203..225		6/21 (29%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		LRR 8	226..249		6/22 (27%)
		leucine-rich repeat	229..251	CDD:275380	6/21 (29%)
		LRR_8	250..307	CDD:290566	20/59 (34%)
		LRR 9	250..272		7/21 (33%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR 10	274..296		9/24 (38%)
		leucine-rich repeat	276..297	CDD:275380	8/23 (35%)
		LRR 11	320..343		7/22 (32%)
		leucine-rich repeat	323..344	CDD:275378	7/20 (35%)
		LRR 12	345..365		10/21 (48%)
		leucine-rich repeat	347..368	CDD:275380	11/22 (50%)
		LRR 13	366..389		5/22 (23%)
		LRR_8	367..427	CDD:290566	24/59 (41%)
		LRR_4	368..406	CDD:289563	13/37 (35%)
		leucine-rich repeat	369..392	CDD:275380	7/22 (32%)
		LRR 14	390..413		12/22 (55%)
		leucine-rich repeat	393..416	CDD:275380	12/22 (55%)
		LRR 15	415..437		8/21 (38%)
		leucine-rich repeat	417..440	CDD:275380	8/22 (36%)
		7tm_1	559..804	CDD:278431	79/251 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1776
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060