DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lingo1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	572	Identity:	149/572 - (26%)
Similarity:	223/572 - (38%)	Gaps:	143/572 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNS 214
            :.|.|  |.:...:.|.....|.||..:|.:..:|||..|.:..|..:.|...|.||||.|::|.
Frog    30 QRCDC--SPQDRSVLCHRKRYLDVPEGIPTDTRLLDLSKNRIKALNQDEFSAFPYLEELELNENI 92

  Fly   215 IINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRT 279
            :..::|.||.||..|:.|.|::..||.:|...|.||:.||.|.::.|.:|.|..|....|..|::
Frog    93 VSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFTGLSNLTQLDISENKIVILLDDMFQDLYNLKS 157

  Fly   280 LRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALK 344
            |.:..|....|...|..||.:||.|.|....||.:..|....:..||.|.|:...|..|...:.|
Frog   158 LEVGDNDLVYISHRAFRGLNSLEELTLEKCNLTSVPTEALSHLHGLITLKLRYLNINVIRDYSFK 222

  Fly   345 NLTALKVLELD-----DNLISSLPEGLSKLSQLQELSITSNR--------------LRWINDT-- 388
            .|..||.||:.     |.:.|:...||:    |..||||.:.              ||::|.:
Frog   223 RLYRLKNLEIAHWPYLDTMTSNGLYGLN----LTSLSITHSNLSSIPYVAIRHLVYLRFLNLSYN 283

  Fly   389 -----------ELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSD--VRTLRSFPELEACHA 440
                       ||.| :|...:....||.:.|.||||::.|:.|.:|.  :.||    |..:.|:
Frog   284 PITAVEGSMLYELLR-LQEFHLVGGQLSVVEPYAFRGLNHLKVLNVSSNYLSTL----EESSFHS 343

  Fly   441 ---LEILKLDRAGI-----------QEVPANLCRQTPRLKSLE-LKTNSLKRI-----PNLSSCR 485
               ||.|.||:..:           :....|..||.|...|.| ::....|..     ||..:||
Frog   344 VGNLETLILDKNPLACDCRLLWIFRRRWRLNFSRQQPSCSSPEYVQGKEFKDFPDVLQPNYFTCR 408

  Fly   486 DLRLLDLSSNQIEKIQG-----------------------KPFNGLKQLNDLLLSYNRIKALPQD 527
            ..|:.|.|:..:...:|                       |.|...|       |..|:...|..
Frog   409 RARIQDHSAQVVYVDEGHTVHFFCRADGDPPPTILWQSPRKTFITSK-------SNGRLTVFPDG 466

  Fly   528 AFQGIPKLQLLD----------LEGNE--ISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRAL 580
            ..: :...|:.|          ..||:  ::::|..::|            ..:|..|.
Frog   467 TLE-VRYAQVQDNGTYHCIASNAGGNDTSLAHLHVRSYS------------PNWPHKPN------ 512

  Fly   581 LHLKTF----NNP------KLREFPPPDTFP-RIQTLILSYAYHCCAFLPLV 621
               |||    |.|      ..|...|   || .|:|||::......:||.:|
Frog   513 ---KTFAFMSNQPNESDVNSTRASVP---FPFDIKTLIIATTMGFISFLGVV 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	70/221 (32%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	25/59 (42%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	20/64 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	72/328 (22%)
		leucine-rich repeat	349..371	CDD:275380	8/26 (31%)
		LRR_8	370..425	CDD:290566	21/81 (26%)
		leucine-rich repeat	372..393	CDD:275380	10/47 (21%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	22/89 (25%)
		leucine-rich repeat	441..464	CDD:275378	8/33 (24%)
		LRR_8	487..545	CDD:290566	14/92 (15%)
		leucine-rich repeat	487..510	CDD:275380	6/45 (13%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	12/71 (17%)
		leucine-rich repeat	535..558	CDD:275380	6/34 (18%)
		leucine-rich repeat	559..580	CDD:275380	2/20 (10%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	8/32 (25%)
		LRR 1	58..79		6/20 (30%)
		leucine-rich repeat	59..82	CDD:275380	6/22 (27%)
		PLN00113	62..>381	CDD:215061	99/327 (30%)
		LRR 2	82..103		9/20 (45%)
		leucine-rich repeat	83..106	CDD:275380	11/22 (50%)
		LRR_8	106..165	CDD:338972	20/58 (34%)
		LRR 3	106..127		7/20 (35%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		5/20 (25%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		LRR 6	178..199		7/20 (35%)
		leucine-rich repeat	179..250	CDD:275380	22/70 (31%)
		LRR 7	202..223		6/20 (30%)
		leucine-rich repeat	203..226	CDD:275380	8/22 (36%)
		LRR 8	250..271		5/24 (21%)
		leucine-rich repeat	251..274	CDD:275380	5/22 (23%)
		LRR 9	274..295		3/20 (15%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		LRR 10	298..319		7/21 (33%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR 11	322..343		6/24 (25%)
		leucine-rich repeat	323..343	CDD:275380	6/23 (26%)
		Ig	425..500	CDD:386229	11/82 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910